« Previous
Next »
Seminars in Oncology
Volume 29, Issue 3
, Pages 246-257
, June 2002
P53 gene mutations: Case study of a clinical marker for solid tumors
References
- Prognostic significance of progesterone receptor levels in estrogen receptor-positive patients with metastatic breast cancer treated with tamoxifen: Results of a prospective Southwest Oncology Group study. J Clin Oncol. 1992;10:1284–1291
- . Role of progesterone receptors in breast cancer. Semin Oncol. 1985;12:12–16
- c-erbB-2 expression and response to adjuvant therapy in women with node-positive early breast cancer. N Engl J Med. 1994;330:1260–1266
- Association of multiple copies of the N-myc oncogene with rapid progression of neuroblastomas. N Engl J Med. 1985;313:1111–1116
- . p53, the cellular gatekeeper for growth and division. Cell. 1997;88:323–331
- . p53: Death star. Cell. 2000;103:691–694
- MDM2 and CDK4 gene amplification in Ewing's sarcoma. J Pathol. 1995;175:211–217
- . Alternative product of the p16/CKDN2A locus connects the Rb and p53 tumor suppressors. Prog Cell Cycle Res. 2000;4:71–81
- . p16(MTS-1/CDKN2/INK4a) in cancer progression. Exp Cell Res. 2001;264:42–55
- Mutations in the p53 tumor suppressor gene: Clues to cancer etiology and molecular pathogenesis. Cancer Res. 1994;54:4855–4878
- . A novel protein with strong homology to the tumor suppressor p53. Oncogene. 1997;15:1363–1367
- Cloning and functional analysis of human p51, which structurally and functionally resembles p53. Nat Med. 1998;4:839–843
- . Another p53 Doppelganger?. Science. 1998;281:57–58
- Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature. 1992;356:215–221
- p53 gene mutations occur in combination with 17p allelic deletions as late events in colorectal tumorigenesis. Cancer Res. 1990;50:7717–7722
- . p53 in tumour pathology: Can we trust immunohistochemistry?—Revisited!. J Pathol. 1994;172:1–4
- Activating mutations in p53 produce a common conformational effect. A monoclonal antibody specific for the mutant form. EMBO J. 1990;9:1595–1602
- . Apoptosis in cancer therapy: Crossing the threshold. Cell. 1994;78:539–542
- An information-intensive approach to the molecular pharmacology of cancer. Science. 1997;275:343–349
- p53-dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell. 1993;74:957–967
- p53 status and the efficacy of cancer therapy in vivo. Science. 1994;266:807–810
- Modulation of activity of the promoter of the human MDR1 gene by Ras and p53. Science. 1992;255:459–462
- . Inactivation of p53 enhances sensitivity to multiple chemotherapeutic agents. Cancer Res. 1996;56:892–898
- Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas and other neoplasms. Science. 1990;250:1233–1238
- Mutated p53 gene is an independent adverse predictor of survival in colon carcinoma. Arch Surg. 1997;132:371–374
- . Clinical response to fluorouracil and p53. N Engl J Med. 2001;345:1065; (letter)
- Molecular predictors of survival after adjuvant chemotherapy for colon cancer. N Engl J Med. 2001;344:1196–1206
- P53 alteration and microsatellite instability have predictive value for survival benefit from chemotherapy in stage III colorectal carcinoma. Clin Cancer Res. 2001;7:1343–1349
-
.
Long-term efficacy of intravesical bacillus Calmette-Guerin for carcinoma in situ: Relationship of progression to histological response and p53 nuclear accumulation.
Urology. 1997;157:1655–1659
- Overexpression of p53 protein in a high-risk population of patients with superficial bladder cancer before and after bacillus Calmette-Guerin therapy: Correlation to clinical outcome. J Clin Oncol. 1996;14:2646–2652
- Significance of p53 overexpression in urinary bladder transitional cell carcinoma in situ before and after bacillus Calmette-Guerin treatment. Urology. 1997;49:541–547
- p53 expression compared with other prognostic factors in Oms grade-I stage-Ta transitional cell carcinoma of the bladder. Eur Urol. 1997;32:229–236
-
p53 nuclear overexpression and disease progression in Ta bladder carcinoma.
Int J Oncol. 1993;3:355–360
- Accumulation of nuclear p53 and tumor progression in bladder cancer. N Engl J Med. 1994;331:1259–1264
- Nuclear overexpression of p53 protein in transitional cell bladder carcinoma: A marker for disease progression. J Natl Cancer Inst. 1993;85:53–59
- Prognostic value of p53 nuclear overexpression in patients with invasive bladder cancer treated with neoadjuvant MVAC. J Clin Oncol. 1995;13:1384–1390
- . p53 and p53-regulated genes in bladder cancer. Br J Urol. 1998;82:710–720
- p53 and treatment of bladder cancer. Nature. 1997;385:123–125
- . Prognostic and predictive value of p53 and p21 in breast cancer. Breast Cancer Res Treat. 1998;52:79–98
- Overexpression of p53 in node-positive breast cancer. Breast Cancer Res Treat. 1993;27:131
- Association of p53 protein expression with tumor cell proliferation rate and clinical outcome in node-negative breast cancer. J Natl Cancer Inst. 1993;85:200–206
- Prognostic significance of p53 gene alterations in node-negative breast cancer. Breast Cancer Res Treat. 1993;26:225–235
- Tumor microvessel density, p53 expression, tumor size, and peritumoral lymphatic vessel invasion are relevant prognostic markers in node-negative breast carcinoma. J Clin Oncol. 1994;12:454–466
- The p53 gene in breast cancer: Prognostic value of complementary DNA sequencing versus immunohistochemistry. J Natl Cancer Inst. 1996;88:173–182
- Accumulation of p53 tumor suppressor gene protein: An independent marker of prognosis in breast cancers. J Natl Cancer Inst. 1992;84:845–855
- p53 protein expression and oestrogen and progesterone receptor status in invasive ductal breast carcinomas. Cytopathology. 2001;12:197–202
- Prognostic factors in breast cancer: College of American Pathologists Consensus Statement 1999. Arch Pathol Lab Med. 2000;124:966–978
- Molecular biomarkers for breast cancer prognosis: Coexpression of c-erbB-2 and p53. Ann Surg. 2001;233:630–638
- p53 in node-negative breast carcinoma: An immunohistochemical study of epidemiologic risk factors, histologic features, and prognosis. J Clin Oncol. 1995;13:821–830
- TP53 mutations in breast cancer associated with BRCA1 or BRCA2 germ-line mutations: Distinctive spectrum and structural distribution. Cancer Res. 2001;61:4092–4097
- . The contribution of molecular markers to the prediction of response in the treatment of breast cancer: A review of the literature on HER-2, p53, and BCL-2. Ann Oncol. 2000;11:647–663
- Specific p53 mutations are associated with de novo reistance to doxorubicin in breast cancer patients. Nat Med. 1996;2:811–814
- Complete sequencing of the p53 gene provides prognostic information in breast cancer patients, particularly in relation to adjuvant systemic therapy and radiotherapy. Nat Med. 1995;1:1029–1034
- p53 mutations and overexpression in locally advanced breast cancers. Br J Cancer. 1994;69:1145–1150
- p53 expression and the result of adjuvant therapy of breast cancer. Acta Oncol. 1995;34:767–770
- Expression of drug resistance in breast cancer, in relation to chemotherapy. Int J Cancer. 1997;71:787–795
- No significant predictive value of c-erb-B2 or p53 expression regarding sensitivity to primary chemotherapy or radiotherapy in breast cancer. Int J Cancer. 1998;79:27–33
- Accumulation of p53 protein as a possible predictor of response to adjuvant combination chemotherapy with cyclophosphamide, methotrexate, fluorouracil and prednisone for breast cancer. J Natl Cancer Inst. 1995;87:1254–1256
- . Clinical significance of p53 in non-small cell lung cancer (review). Oncol Rep. 1999;6:19–28
- Tumor angiogenesis and biologic markers in resected stage I NSCLC. Eur J Cardiothorac Surg. 1997;12:535–541
- Immunocytochemical markers in stage I lung cancer: Relevance to prognosis. J Clin Oncol. 1997;15:2858–2865
- A prognostic model of recurrence and death in stage I non-small cell lung cancer utilizing presentation, histopathology, and oncoprotein expression. Cancer Res. 1995;55:51–56
- TP53 mutations in prostatic cancer. Analysis of pre- and post- treatment archival formalin-fixed tumour tissue. J Pathol. 1995;176:299–308
- Correlation of genetic and immunodetection of TP53 mutations in malignant and benign prostate tissues. Hum Pathol. 1996;27:573–580
- p53 protein accumulation and gene mutation in the progression of human prostate carcinoma. J Natl Cancer Inst. 1993;85:1657–1669
- Clustered p53 immunostaining: A novel pattern associated with prostate cancer progression. Clin Cancer Res. 1996;2:399–401
- p53 nuclear protein expression is an independent prognostic marker in clinically localized prostate cancer patients undergoing radical prostatectomy. Clin Cancer Res. 1995;1:1295–1300
- p53 status and prognosis of locally advanced prostatic adenocarcinoma: A study based on RTOG 8610. J Natl Cancer Inst. 1997;89:158–165
- Small subgroup of aggressive, highly proliferative prostatic carcinomas defined by p53 accumulation. J Natl Cancer Inst. 1992;84:883–887
- p53 expression and clinical outcome in prostate cancer. Br J Urol. 1993;72:778–781
- Proliferating cell nuclear antigen and p53 expression as prognostic factors in T1-2M0 prostatic adenocarcinoma. Int J Cancer. 1994;58:303–308
- . Immunohistochemical detection of p53 protein as a prognostic indicator in prostate cancer. Hum Pathol. 1995;26:106–109
- Elevated levels of apoptosis regulator proteins p53 and bcl-2 are independent prognostic biomarkers in surgically treated clinically localized prostate cancer. J Urol. 1996;156:1511–1516
- Protein expression of p53, bcl-2, and KI-67 (MIB-1) as prognostic biomarkers in patients with surgically treated, clinically localized prostate cancer. Surgery. 1996;120:159–167
- Combined analysis with Bcl-2 and P53 immunostaining predicts poorer prognosis in prostatic carcinoma. J Urol. 1997;158:2278–2283
- p53, bcl-2 and retinoblastoma proteins as long-term prognostic markers in localized carcinoma of the prostate. J Urol. 1997;158:131–137
- Assessment of the biologic markers p53, Ki-67, and apoptotic index as predictive indicators of prostate carcinoma recurrence after surgery. Cancer. 1998;82:168–175
- An evaluation of the markers p53 and Ki-67 for their predictive value in prostate cancer. J Surg Oncol. 1998;67:33–37
- Prognostic significance of Ki-67, p53, and Bcl-2 expression in prostate cancer patients with lymph node metastases: A retrospective immunohistochemical analysis. Pathol Int. 1998;48:41–46
- Expression of bcl-2 oncoprotein and p53 protein accumulation in bone marrow metastases of androgen independent prostate cancer. J Urol. 1997;157:569–574
- p53 alteration in regional lymph node metastases from prostate carcinoma: A marker for progression?. Cancer. 1999;85:2455–2459
- p53 gene status as a predictor of tumor response to induction chemotherapy of patients with locoregionally advanced squamous cell carcinomas of the head and neck. J Clin Oncol. 2000;18:385–394
- p53 alterations predict tumor response to neoadjuvant chemotherapy in head and neck squamous cell carcinoma: A prospective series. J Clin Oncol. 2000;18:1465–1473
-
.
Molecular staging of head and neck squamous carcinoma.
Cancer Metast Rev. 1996;15:3–10
- p53 gene mutation and protein accumulation during neoplastic progression in Barrett's esophagus. Mod Pathol. 2001;14:397–403
- Diagnostic value of p53 immunohistochemistry in Barrett's esophagus: An endoscopic study. Pathology. 1998;30:136–140
- The incidence of p53 mutations increases with progression of head and neck cancer. Cancer Res. 1993;53:4477–4480
- Association between cigarette smoking and mutation of the p53 gene in squamous-cell carcinoma of the head and neck. N Engl J Med. 1995;332:712–717
- Predicting cancer development in oral leukoplakia: Ten years of translational research. Clin Cancer Res. 2000;6:1702–1710
-
Pretreatment biomarkers predict response of advanced head and neck premalignant lesions to biochemoprevention.
Proc Am Soc Clin Oncol. 2000;19:1636;
(abstr)
- Identification of p53 gene mutations in bladder cancers and urine samples. Science. 1991;252:706–709
- . Cancer: p53, guardian of the genome. Nature. 1992;358:15–16
- Improving the detection of p53 mutations in breast cancer by use of the FASAY, a functional assay. J Mol Diagn. 2000;2:139–144
☆ Address reprint requests to Edward P. Gelmann, MD, Department of Oncology, Lombardi Cancer Center, Georgetown University School of Medicine, 3800 Reservoir Rd NW, Washington, DC 20007-2197. Email gelmanne@georgetown.edu.
PII: S0093-7754(02)50180-9
doi: 10.1053/sonc.2002.32900
« Previous
Next »
Seminars in Oncology
Volume 29, Issue 3
, Pages 246-257
, June 2002
