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Seminars in Oncology
Volume 30, Issue 5
, Pages 678-688
, October 2003
Endothelin receptor antagonists in the treatment of prostate cancer
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A placebo controlled phase II dose-ranging evaluation of an endothelin-A receptor antagonist for men with hormone refractory prostate cancer (HRPCA) and disease related pain.
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The selective endothelin receptor-A antagonist atrasentan improves quality of life adjusted time to progression (QATTP) in hormone refractory prostate cancer patients.
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Effects of atrasentan on progression and survival in men with hormone refractory prostate cancer (Follow-up to study M96–594).
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Abbott Laboratories Provides Update on Phase III Atrasentan Clinical Trials in Men with Advanced Prostate Cancer. 2003;
http://abbott.com/news/press_release.cfm?id=533. Feb 10
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Endothelin-1 dependent and independent mechanisms concur in the increased bone mass of prostate cancer bone metastases.
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☆ Supported by Abbott Laboratories. M.A.C. is a paid consultant for Abbott Laboratories. The terms of this arrangement are being managed by the Johns Hopkins University in accordance with its conflict of interest policies.
PII: S0093-7754(03)00353-1
doi: 10.1016/S0093-7754(03)00353-1
© 2003 Elsevier Inc. All rights reserved.
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Seminars in Oncology
Volume 30, Issue 5
, Pages 678-688
, October 2003
