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Seminars in Oncology
Volume 31, Issue 1
, Pages 56-67
, February 2004
Immunoablative reduced-intensity stem cell transplantation: potential role of donor Th2 and Tc2 cells
References
-
Regimen-related acute toxicities (Pathophysiology, risk factors, clinical evaluation, and preventative strategies).
Bone Marrow Transplant. 1994;14(suppl 4):S14–S18
-
Demonstration of clonable alloreactive host T-cells in a primate model for bone marrow transplantation.
Proc Natl Acad Sci USA. 1986;83:4012–4015
- The role of host T-cell subsets in bone marrow rejection directed to isolated major histocompatibility complex class I versus class II differences of bm1 and bm12 mutant mice. Transplantation. 1994;57:249–256
- Graft failure in patients receiving T-cell-depleted HLA-identical allogeneic marrow transplants. Bone Marrow Transplant. 1988;3:445–456
- . Graft rejection and graft-versus-host disease (Mirror images). Lancet. 1986;1:1468–1470
- . Determinants of engraftment after allogeneic marrow transplantation. Blood. 1992;79:1647–1650
- Transplant-lite (Induction of graft-versus-malignancy using fludarabine-based nonablative chemotherapy and allogeneic blood progenitor-cell transplantation as treatment for lymphoid malignancies). J Clin Oncol. 1998;16:2817–2824
- Intentional induction of mixed chimerism and achievement of antitumor responses after nonmyeloablative conditioning therapy and HLA-matched donor bone marrow transplantation for refractory hematologic malignancies. Biol Blood Marrow Transplant. 2000;6:309–320
- Hematopoietic cell transplantation in older patients with hematologic malignancies (Replacing high-dose cytotoxic therapy with graft-versus-tumor effects). Blood. 2001;97:3390–3400
- Constraints on CD4 recovery postchemotherapy in adults (Thymic insufficiency and apoptotic decline of expanded peripheral CD4 cells). Blood. 1997;90:3789–3798
- . Mixed chimerism and transplant tolerance. Immunity. 2001;14:417–424
- Host T-cells resist graft-versus-host disease mediated by donor leukocyte infusions. J Immunol. 2000;165:4901–4909
- Engraftment kinetics after nonmyeloablative allogeneic peripheral blood stem cell transplantation (Full donor T-cell chimerism precedes alloimmune responses). Blood. 1999;94:3234–3241
- . Graft-versus-host disease in experimental allogeneic bone marrow transplantation. Proc Soc Exp Biol Med. 1991;197:12–18
- Successful allogeneic transplantation of T-cell-depleted bone marrow from closely HLA-matched unrelated donors. N Engl J Med. 1990;322:485–494
- Influence of HLA-DPB1 disparity on the development of acute graft-versus-host disease following unrelated donor marrow transplantation. Transplant Proc. 1993;25:1230–1231
- Correlation between disparity for the minor histocompatibility antigen HA-1 and the development of acute graft-versus-host disease after allogeneic marrow transplantation. Blood. 1999;94:2911–2914
- Recipient tumor necrosis factor-alpha and interleukin-10 gene polymorphisms associate with early mortality and acute graft-versus-host disease severity in HLA-matched sibling bone marrow transplants. Blood. 1999;94:3941–3946
- Prevention of graft versus host disease by inactivation of host antigen-presenting cells. Science. 1999;285:412–415
- Total body irradiation and acute graft-versus-host disease (The role of gastrointestinal damage and inflammatory cytokines). Blood. 1997;90:3204–3213
- Differential roles of IL-1 and TNF-alpha on graft-versus-host disease and graft versus leukemia. J Clin Invest. 1999;104:459–467
- . The primacy of the gastrointestinal tract as a target organ of acute graft-versus-host disease (Rationale for the use of cytokine shields in allogeneic bone marrow transplantation). Blood. 2000;95:2754–2759
- Macrophage priming and lipopolysaccharide-triggered release of tumor necrosis factor alpha during graft-versus-host disease. J Exp Med. 1992;175:405–413
- . Non-myeloablative stem cell transplants. Br J Haematol. 2000;111:6–17
- Nonablative allogeneic hematopoietic transplantation as adoptive immunotherapy for indolent lymphoma (Low incidence of toxicity, acute graft-versus-host disease, and treatment-related mortality). Blood. 2001;98:3595–3599
- Nonmyeloablative stem cell transplantation and cell therapy as an alternative to conventional bone marrow transplantation with lethal cytoreduction for the treatment of malignant and nonmalignant hematologic diseases. Blood. 1998;91:756–763
- Melphalan and purine analog-containing preparative regimens (Reduced-intensity conditioning for patients with hematologic malignancies undergoing allogeneic progenitor cell transplantation). Blood. 2001;97:631–637
- Rapid achievement of complete donor chimerism and low regimen-related toxicity after reduced conditioning with fludarabine, carmustine, melphalan and allogeneic transplantation. Bone Marrow Transplant. 2000;26:243–250
- Donor lymphocyte infusions mediate superior graft-versus-leukemia effects in mixed compared to fully allogeneic chimeras (A critical role for host antigen-presenting cells). Blood. 2002;100:1903–1909
- Mixed lymphohaemopoietic chimerism and graft-versus-lymphoma effects after non-myeloablative therapy and HLA-mismatched bone-marrow transplantation. Blood. 1998;91:4045–4050
- Minimal residual disease is more common in patients who have mixed T-cell chimerism after bone marrow transplantation for chronic myelogenous leukemia. Blood. 1994;83:3409–3416
- Incidence of mixed chimaerism and clinical outcome in 101 patients after myeloablative conditioning regimens and allogeneic stem cell transplantation. Br J Haematol. 2000;109:743–750
- Regression of metastatic renal-cell carcinoma after nonmyeloablative allogeneic peripheral-blood stem-cell transplantation. N Engl J Med. 2000;343:750–758
- Chemoresistant or aggressive lymphoma predicts for a poor outcome following reduced-intensity allogeneic progenitor cell transplantation (an analysis from the Lymphoma Working Party of the European Group for Blood and Bone Marrow Transplantation). Blood. 2002;100:4310–4316
- An immunoablative regimen of fludarabine and cyclophosphamide prevents fully MHC-mismatched murine marrow graft rejection independent of GVHD. Biol Blood Marrow Transplant. 2000;6:182–189
- Establishment of early donor engraftment after reduced-intensity allogeneic hematopoietic stem cell transplantation to potentiate the graft-versus-lymphoma effect against refractory lymphomas. Biol Blood Marrow Transplant. 2003;9:162–169
- Role of a doxorubicin-containing regimen in relapsed and resistant lymphomas (An 8-year follow-up study of EPOCH). J Clin Oncol. 2000;18:3633–3642
- Fludarabine and cyclophosphamide with filgrastim support in patients with previously untreated indolent lymphoid malignancies. Blood. 2000;96:71–75
- Mitoxantrone, a topoisomerase II inhibitor, induces apoptosis of B-chronic lymphocytic leukaemia cells. Br J Haematol. 1998;100:142–146
- Results of fludarabine and prednisone therapy in 264 patients with chronic lymphocytic leukemia with multivariate analysis-derived prognostic model for response to treatment. Blood. 1993;82:1695–1700
- Controlled trial of filgrastim for acceleration of neutrophil recovery after allogeneic blood stem cell transplantation from human leukocyte antigen-matched related donors. Blood. 2001;97:3405–3410
- Detection of chimerism and early engraftment after allogeneic peripheral blood stem cell or bone marrow transplantation by short tandem repeats. Am J Hematol. 1996;52:281–287
- Autografting followed by nonmyeloablative immunosuppressive chemotherapy and allogeneic peripheral-blood hematopoietic stem-cell transplantation as treatment of resistant Hodgkin’s disease and non-Hodgkin’s lymphoma. J Clin Oncol. 2000;18:3918–3924
- Two types of murine helper T-cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J Immunol. 1986;136:2348–2357
- . Final steps of natural killer cell maturation (a model for type 1-type 2 differentiation?). Nat Immunol. 2001;2:917–924
- IL-12-deficient dendritic cells, generated in the presence of prostaglandin E2, promote type 2 cytokine production in maturing human naive T helper cells. J Immunol. 1997;159:28–35
- . Relative perforin- and Fas-mediated lysis in T1 and T2 CD8 effector populations. J Immunol. 1995;155:1028–1031
- Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro (IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells). J Exp Med. 1990;172:921–929
- Role of NK1.1+ T-cells in a TH2 response and in immunoglobulin E production. Science. 1995;270:1845–1847
- . Induction of Th1 and Th2 CD4+ T-cell responses (The alternative approaches). Annu Rev Immunol. 1997;15:297–322
- Reciprocal control of T helper cell and dendritic cell differentiation. Science. 1999;283:1183–1186
- Calcium signaling inhibits interleukin-12 production and activates CD83(+) dendritic cells that induce Th2 cell development. Blood. 2001;98:2489–2497
- . Cytokine-induced differentiation of precursor mouse CD8+ T-cells into cytotoxic CD8+ T-cells secreting Th1 or Th2 cytokines. Immunity. 1995;2:271–279
- . Interleukin-1 is a critical effector molecule during cytokine dysregulation in graft versus host disease to minor histocompatibility antigens. Transplantation. 1993;56:1518–1523
- . Critical role of interleukin-2 in the development of acute graft-versus-host disease. Int Immunol. 1993;5:565–572
- Helper T-lymphocyte precursor frequencies predict risks of graft-versus-host disease in bone marrow transplantation. Transplant Proc. 1993;25:1237–1238
- The biological outcome of CD40 signaling is dependent on the duration of CD40 ligand expression (Reciprocal regulation by interleukin (IL)-4 and IL-12). J Exp Med. 2002;196:693–704
- Blockade of CD40 ligand-CD40 interaction impairs CD4+ T-cell-mediated alloreactivity by inhibiting mature donor T-cell expansion and function after bone marrow transplantation. J Immunol. 1997;158:29–39
- A major role for the Fas pathway in acute graft-versus-host disease. J Immunol. 1996;157:5387–5393
- Differential use of Fas ligand and perforin cytotoxic pathways by donor T-cells in graft-versus-host disease and graft-versus-leukemia effect. Blood. 2001;97:2886–2895
- Fas ligand- mediated killing by intestinal intraepithelial lymphocytes. Participation in intestinal graft-versus-host disease. J Clin Invest. 1998;101:570–577
- The role of donor T-cells for target organ injuries in acute and chronic graft-versus-host disease. Immunology. 2001;103:310–318
- Acute graft-versus-host disease does not require alloantigen expression on host epithelium. Nat Med. 2002;8:575–581
- Tumor necrosis factor-alpha-dependent production of reactive nitrogen intermediates mediates IFN-gamma plus IL-2-induced murine macrophage tumoricidal activity. J Immunol. 1992;149:3290–3296
- Role of T-cell derived cytokines in the downregulation of immune responses in parasitic and retroviral infection. Immunol Rev. 1992;127:183–204
- Cells of Th2 cytokine phenotype prevent LPS-induced lethality during murine graft-versus-host reaction. Regulation of cytokines and CD8+ lymphoid engraftment. J Immunol. 1994;152:1004–1013
- Donor CD4-enriched cells of Th2 cytokine phenotype regulate graft-versus-host disease without impairing allogeneic engraftment in sublethally irradiated mice. Blood. 1994;84:3540–3549
- Polarized type 2 alloreactive CD4+ and CD8+ donor T-cells fail to induce experimental acute graft-versus-host disease. J Immunol. 1995;155:585–593
- Allospecific CD4+, Th1/Th2 and CD8+, Tc1/Tc2 populations in murine GVL (type I cells generate GVL and type II cells abrogate GVL). Biol Blood Marrow Transplant. 1996;2:118–125
- Allospecific CD8+ Tc1 and Tc2 populations in graft-versus-leukemia effect and graft-versus-host disease. J Immunol. 1996;157:4811–4821
- CD3, CD28 co-stimulated T1 vs. T2 subsets (Differential in vivo allosensitization generates distinct GVT and GVHD effects). Blood. 2003;102:3439–3446
- . Therapeutic effects of tumor-reactive type 1 and type 2 CD8+ T-cell subpopulations in established pulmonary metastases. J Immunol. 1999;162:6671–6680
- . Tumor-specific Tc1, but not Tc2, cells deliver protective antitumor immunity. J Immunol. 2001;167:6497–6502
- Pretreatment of donor mice with granulocyte colony-stimulating factor polarizes donor T lymphocytes toward type-2 cytokine production and reduces severity of experimental graft-versus-host disease. Blood. 1995;86:4422–4429
- Pharmacologic doses of granulocyte colony-stimulating factor affect cytokine production by lymphocytes in vitro and in vivo. Blood. 2000;95:2269–2274
- Granulocyte-colony stimulating factor mobilizes T helper 2-inducing dendritic cells. Blood. 2000;95:2484–2490
- Effects of CD28 costimulation on long-term proliferation of CD4+ T-cells in the absence of exogenous feeder cells. J Immunol. 1997;159:5921–5930
- Adoptive transfer of costimulated CD4+ T-cells induces expansion of peripheral T-cells and decreased CCR5 expression in HIV infection. Nat Med. 2002;8:47–53
- T-cells coactivated with immobilized anti-CD3 and anti-CD28 as potential immunotherapy for cancer. J Immunother. 1999;22:336–345
- CD28 costimulation can promote T-cell survival by enhancing the expression of Bcl-XL. Immunity. 1995;3:87–98
- A point mutation in CD28 distinguishes proliferative signals from survival signals. Nat Immunol. 2001;2:325–332
- Limited role of CD28-mediated signals in T helper subset differentiation. J Exp Med. 1996;184:803–810
- Phase I clinical trial of donor T-helper Type-2 cells after immunoablative, reduced intensity allogeneic PBSC transplant. Cytotherapy. 2002;4:429–430
- . Donor CD8 cells prevent allogeneic marrow graft rejection in mice (Potential implications for marrow transplantation in humans). J Exp Med. 1993;178:703–712
- A phase I-II clinical trial to evaluate removal of CD4 cells and partial depletion of CD8 cells from donor marrow for HLA-mismatched unrelated recipients. Blood. 1999;94:2192–2199
- . Veto cells. Annu Rev Immunol. 1988;6:115–137
- Clonal deletion of postthymic T-cells (Veto cells kill precursor cytotoxic T lymphocytes). J Exp Med. 1992;175:863–868
- Anti-third party CD8+ CTLs as potent veto cells (Coexpression of CD8 and FasL is a prerequisite). Immunity. 2000;13:507–515
- A role for perforin in activation-induced T-cell death in vivo (Increased expansion of allogeneic perforin-deficient T-cells in SCID mice). J Immunol. 1999;162:1192–1199
- . Veto activity of activated bone marrow does not require perforin and Fas ligand. Cell Immunol. 2001;208:80–87
- . The molecular mechanisms of veto mediated regulation of alloresponsiveness. J Mol Med. 1999;77:519–526
- Bone marrow transplantation across major genetic barriers (The role of megadose stem cells and nonalloreactive donor anti-third party CTLS). Transplant Proc. 2001;33:2099–2100
- . Haploidentical ‘megadose’ CD34+ cell transplants for patients with acute leukemia. Leukemia. 2002;16:404–405
- . Interleukin 2 enhancement of veto suppressor cell function in T-cell-depleted bone marrow in vitro and in vivo. Transplantation. 1990;49:931–937
- Tolerance induction by megadose stem cell transplants (Synergism between SCA-1+ Lin- cells and nonalloreactive T-cells). Transplant Proc. 1998;30:4007–4008
- . Prevention of allogeneic marrow graft rejection by donor T-cells that do not recognize recipient alloantigens (Potential role of a veto mechanism). Blood. 1996;88:962–969
- Non-host-reactive donor CD8+ T-cells of Tc2 phenotype potently inhibit marrow graft rejection. Blood. 1998;91:4045–4050
- Specific depletion of alloreactive T-cells in HLA-identical siblings (A method for separating graft-versus-host and graft-versus-leukaemia reactions). Br J Haematol. 1998;101:565–570
- Transplantation of polarized type 2 donor T-cells reduces mortality caused by experimental graft-versus-host disease. Transplantation. 1996;62:1278–1285
- In vitro generation of allospecific human CD8+ T-cells of Tc1 and Tc2 phenotype. Blood. 1997;90:2089–2096
PII: S0093-7754(03)00565-7
doi: 10.1053/j.seminoncol.2003.11.003
© 2004 Elsevier Inc. All rights reserved.
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Seminars in Oncology
Volume 31, Issue 1
, Pages 56-67
, February 2004
