Seminars in Oncology
Volume 31, Issue 1 , Pages 83-89, February 2004

The role of monoclonal antibodies in stem cell transplantation

  • Tarun Wasil

      Affiliations

    • Long Island Jewish Medical Center, Division of Hematology-Oncology, New Hyde Park, NY, USA
    • Albert Einstein College of Medicine, Bronx, NY, USA
    • Corresponding Author InformationAddress reprint requests to Tarun Wasil, MBBS, Attending Physician, Long Island Jewish Medical Center, 270-05 76th Ave, New Hyde Park, NY, 11040, USA
    • ,
  • Kanti R Rai

      Affiliations

    • Long Island Jewish Medical Center, Division of Hematology-Oncology, New Hyde Park, NY, USA
    • Albert Einstein College of Medicine, Bronx, NY, USA
    • ,
  • Bhoomi Mehrotra

      Affiliations

    • Long Island Jewish Medical Center, Division of Hematology-Oncology, New Hyde Park, NY, USA
    • Albert Einstein College of Medicine, Bronx, NY, USA

Abstract 

Monoclonal antibodies directed at the lymphoid antigens have become established treatments for hematological malignancies either alone or in combination with chemotherapy. However, their incorporation in the transplant setting remains investigational. This review focuses on the currently available data for in vitro and in vivo purging with these antibodies as well as their role in modulating graft-versus-host disease (GVHD).

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PII: S0093-7754(03)00567-0

doi:10.1053/j.seminoncol.2003.11.005

Seminars in Oncology
Volume 31, Issue 1 , Pages 83-89, February 2004

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