Seminars in Oncology
Volume 31, Issue 2 , Pages 137-148 , April 2004

Aging biology and cancer

  • Neelima Denduluri

      Affiliations

    • Institute for Advanced Studies in Aging & Geriatric Medicine, Washington, DC, USA
  • ,
  • William B Ershler

      Affiliations

    • Institute for Advanced Studies in Aging & Geriatric Medicine, Washington, DC, USA
    • Corresponding Author InformationAddress reprint requests to William B. Ershler, MD, Institute for Advanced Studies in Aging & Geriatric Medicine, 1700 Wisconsin Ave NW, Washington, DC 20007, USA

References 

  1. Duthie EH. Physiology of aging (Relevance to symptoms, perceptions and treatment tolerance). In:  Balducci L,  Lyman G,  Ershler WB editor. Comprehensive Geriatric Oncology. Amsterdam, The Netherlands: Harwood Academic; 1998;p. 247–262
  2. Lindeman RD. Overview (Renal physiology and pathophysiology of aging). Am J Kidney Dis. 1990;16:275–282
  3. Harrison DE. Proliferative capacity of erythropoietic stem cell lines and aging (An overview). Mech Ageing Dev. 1979;9:409–426
  4. Harrison DE, Astle CM, Stone M. Numbers and functions of transplantable primitive immunohematopoietic stem cells. Effects of age. J Immunol. 1989;142:3833–3840
  5. Artz AS, Fergusson D, Drinka PJ, et al.  Mechanisms of anemia in the nursing home. J Am Geriatr Soc. 2004;52:423–472
  6. Izaks GJ, Westendorp RG, Knook DL. The definition of anemia in older persons. JAMA. 1999;281:1714–1717
  7. Ania BJ, Suman VJ, Fairbanks VF, et al.  Incidence of anemia in older people (An epidemiologic study in a well-defined population). J Am Geriatr Soc. 1997;45:825–831
  8. Chen LH, Cook-Newell ME. Anemia and iron status in the free-living and institutionalized elderly in Kentucky. Int J Vitam Nutr Res. 1989;59:207–213
  9. Chernetsky A, Sofer O, Rafael C. Prevalence and etiology of anemia in an institutionalized geriatric population. Harefuah. 2002;141:591–594667
  10. Balducci L, Hardy CL, Lyman GH. Hemopoietic reserve in the older cancer patient (Clinical and economic considerations). Cancer Control. 2000;6:539–547
  11. Rothstein G. Disordered hematopoiesis and myelodysplasia in the elderly. J Am Geriatr Soc. 2003;51(suppl):S22–S26
  12. Balducci L, Carreca I. The role of myelopoietic growth factors in managing cancer in the elderly. Drugs. 2002;62(suppl 1):47–63
  13. Grubeck-Loebenstein B, Wick G. The aging of the immune system. Adv Immunol. 2002;80:243–284
  14. Dubrow EL. Reactivation of tuberculosis (A problem of aging). J Am Geriatr Soc. 1976;24:481–487
  15. Nagami PH, Yoshikawa TT. Tuberculosis in the geriatric patient. J Am Geriatr Soc. 1983;31:356–363
  16. Gelato MC. Aging and immune function (A possible role for growth hormone). Hormone Res. 1996;45:46–49
  17. Arden NH, Patriarca PA, Kendal AP. Experiences in the use and efficacy of inactivated influenza vaccine in the nursing home. In:  Kendal AP,  Patriarca PA editor. Options for the Control of Influenza. New York, NY: Liss; 1986;p. 155–168
  18. Powers DC, Sears SD, Murphy BR, et al.  Systemic and local antibody responses in elderly subjects give live or inactivated influenza A virus vaccines. J Clin Microbiol. 1989;27:2666–2671
  19. Hilleman RM. Realities and enigmas of human viral influenza (Pathogenesis, epidemiology and control). Vaccine. 2002;20:3068–3087
  20. Kaesberg PR, Ershler WB. The importance of immune senescence in the incidence and malignant properties of cancer in hosts of advanced age. J Gerontology. 1989;44:63–66
  21. Christensen K, Vaupel JW. Determinants of longevity (Genetic, environmental and medical factors). J Intern Med. 1996;240:333–341
  22. Guyer B, Strobino DM, Ventura SJ, et al.  Annual summary of vital statistics-1995. Pediatrics. 1996;98:1007–1019
  23. Greville TNE. U.S. life tables by cause of death (1969–1971). In: U.S. Decennial Life Tables for 1969–1971. Hyattsville, MD: National Center for Health Statistics; 1971;p. 5–15
  24. Riggs JE. Longitudinal Gompertzian analysis of adult mortality in the U.S., 1900–1986. Mech Ageing Dev. 1990;54:235–247
  25. Hirsch HR. Can an improved environment cause maximum survival to decrease? Comments on lifespan criteria and longitudinal Gompertzian analysis. Exp Gerontol. 1994;29:119–137
  26. Orr WC, Sohal RS. Extension of life-span by overexpression of superoxide dismutase and catalase in Drosophila melanogaster. Science. 1994;263:1128–1130
  27. Weindruch R. Caloric restriction and aging. Sci Am. 1996;274:46–52
  28. Cristofalo VJ, Pignolo RJ. Replicative senescence of human fibroblast-like cells in culture. Physiol Rev. 1993;73:617–638
  29. Hayflick L. The limited in vitro lifetime of human diploid cell strains. Exp Cell Res. 1965;37:614–636
  30. Cristofalo VJ. Cell culture aging (Insights for cell aging in vivo?). Aging (Milano). 1999;11:1–3
  31. Schneider EL, Mitsui Y. The relationship between in vitro cellular aging and in vivo human age. Proc Natl Acad Sci U S A. 1976;73:3584–3588
  32. Rohme D. Evidence for a relationship between longevity of mammalian species and life-spans of normal fibroblasts in vitro and erythrocytes in vivo. Proc Natl Acad Sci U S A. 1976;78:5009–5013
  33. Dimri GP, Lee X, Basile G, et al.  A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci U S A. 1995;92:9363–9367
  34. Martin GM. The genetics of aging. Hosp Pract. 1997;32:47–50
  35. Yu CE, Oshima J, Fu YH, et al.  Positional cloning of the Werner’s syndrome gene. Science. 1996;272:258–262
  36. Yu CE, Oshima J, Wijsman EM, et al.  Mutations in the consensus helicase domains of the Werner syndrome gene. Am J Genet. 1997;60:330–341
  37. Eriksson M, Brown WT, Gordon LB, et al.  Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome. Nature. 2003;423:293–298
  38. Kennedy BK, Guarente L. Genetic analysis of aging in Saccharomyces cerevisiae. Trends Genet. 1996;12:355–359
  39. Szilard L. On the nature of the aging process. Proc Natl Acad Sci U S A. 1959;45:30–35
  40. Morley AA. Is aging the result of dominant or co-dominant mutations. J Theor Biol. 1982;98:469–474
  41. Cummings DJ. Mitochondrial DNA in Podopora anserina (A molecular approach to cellular senescence). Monogr Dev Biol. 1984;17:254–266
  42. Fairweather S, Fox M, Margison BP. The in vitro life-span of MRC-5 cells is shortened by 5-azacytidine-induced demethylation. Exp Cell Res. 1987;168:153–158
  43. Burnet M. Intrinsic Mutagenesis (A Genetic Approach for Aging). New York, NY: Wiley; 1974;
  44. Hart RW, Setlow RB. Correlation between deoxyribonucleic acid excision-repair and lifespan in a number of mammalian species. Proc Natl Acad Sci U S A. 1974;71:2169–2173
  45. Orgel LE. The maintenance of the accuracy of protein synthesis and its relevance to aging. Proc Natl Acad Sci U S A. 1963;49:517–521
  46. Allsop RC, Vaziri H, Patterson C, et al.  Telomere length predicts replicative capacity of human fibroblasts. Proc Natl Acad Sci U S A. 1992;89:10114–10118
  47. Bjorksten J, Tenhu H. The crosslinking theory of aging (Added evidence). Exp Gerontol. 1990;25:91–95
  48. Schnider SL, Kohn RR. Glycosylation of human collagen in aging and diabetes mellitus. J Clin Invest. 1980;66:1179–1181
  49. Kreisle RA, Stebler B, Ershler WB. Effect of host age on tumor associated angiogenesis in mice. J Natl Cancer Inst. 1990;82:44–47
  50. Harman D. Aging (A theory based on free radical and radiation chemistry). J Gerontol. 1956;11:298–300
  51. Harman D. The aging process. Proc Natl Acad Sci U S A. 1981;78:7124–7128
  52. Sohal RS, Svensson I, Sohal BH, et al.  Superoxide radical production in different animal species. Mech Ageing Dev. 1989;49:129–135
  53. Sohal RS, Sohal BH, Brunk UT. Relationship between antioxidant defenses and longevity in different mammalian species. Mech Ageing Dev. 1990;53:217–227
  54. Sohal RS, Allen RG. Oxidative stress as a causal factor in differentiation and aging (A unifying hypothesis). Exp Gerontol. 1990;25:499–522
  55. Lee CM, Chung SS, Kaczkowski JM, et al.  Multiple mitochondrial DNA deletions associated with age in skeletal muscle of rhesus monkeys. J Gerontol. 1993;48:B201–B205
  56. Schwarze SR, Lee CM, Chung SS, et al.  High levels of mitochondrial DNA deletions in skeletal muscle of old rhesus monkeys. Mech Ageing Dev. 1995;83:91–101
  57. Melov S, Shoffner JM, Kaufman A, et al.  Marked increase in the number and variety of mitochondrial DNA rearrangements in aging human skeletal muscle. Nucleic Acids Res. 1995;23:4122–4126
  58. Li Y, Huang YY, Carlson EJ, et al.  Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase. Nature. 1995;11:376–381
  59. Sohal RS. Hydrogen peroxide production by mitochondria may be a biomarker of aging. Mech Ageing Dev. 1991;60:189–198
  60. Epstein CJ, Avraham KB, Lovett M. Transgenic mice with increased Cu/Zn-superoxide dismutase activity (Animal model of dosage effects in Down’s syndrome). Proc Natl Acad Sci U S A. 1987;84:8044–8048
  61. Harris TB, Roubenoff RR, Langlois J, et al.  Association of insulin-like growth factor-I with body composition, weight history, and past health behaviors in the very old (The Framingham Heart Study). J Am Geriatr Soc. 1997;45:133–139
  62. Birkenhager-Gillesse EG, Derkson J, Lagaay AM. Dehydroepiandrosterone sulfate (DHEAS) in the oldest old, aged 85 and over. Ann NY Acad Sci. 1994;719: 543–542
  63. Rudman D, Drinka PJ, Wilson CR, et al.  Relations of endogenous anabolic hormones and physical activity to bone mineral density and lean body mass in elderly men. Clin Endocrinol. 1994;40:653–661
  64. Rudman D, Feller AG, Nagraj HS, et al.  Effects of human growth hormone in men over 60 years old. N Engl J Med. 1990;323:1–6
  65. Hobbs CJ, Plymate SR, Rosen CJ, et al.  Testosterone administration increases insulin-like growth facto-1 levels in normal men. J Clin Endocrinol Metab. 1993;77:776–779
  66. Walford R. The Immunologic Theory of Aging. Copenhagen, Denmark: Munksgard; 1969;
  67. Makinodan T, Kay MMB. Age influence on the immune system. Adv Immunology. 1980;29:287–330
  68. Smith GS, Walford RL. Influence of the main histocompatibility complex on aging in mice. Nature. 1977;270:727–729
  69. Hirokawa K, Albright JW, Makinodan T. Restoration of impaired immune function in aging animals. I. Effect of syngeneic thymus and bone marrow grafts. Clin Immunol Immunopathol. 1985;5:371–376
  70. Gatti RQ, Good RA. Aging, immunity and malignancy. Geriatrics. 1979;25:158–168
  71. Bulychev VV. Longevity, atherosclerosis and cellular immunity. Klin Med (Mosk). 1993;71:51–54
  72. Hansson GK, Libby P, Schonbeck U, et al.  Innate and adaptive immunity in the pathogenesis of atherosclerosis. Circ Res. 2002;91:281–291
  73. Lehuen A, Bendelac A, Bach JF, et al.  The nonobese diabetic mouse model. Independent expression of humoral and cell mediated autoimmune features. J Immunol. 1990;144:2147–2151
  74. Hull M, Strauss S, Berger M, et al.  The participation of interleukin-6, a stress-inducible cytokine, in the pathogenesis of Alzheimer’s disease. Behav Brain Res. 1996;78:37–41
  75. Hull M, Fiebich BL, Lieb S, et al.  Interleukin-6-associated inflammatory processes in Alzheimer’s disease (New therapeutic options). Neurobiol Aging. 1996;17:795–800
  76. Gillis S, Kozak R, Durante M, et al.  Decreased production and response to T cell growth factor by lymphocytes from aged humans. J Clin Invest. 1981;67:937–942
  77. Miller RA. The aging immune system (primer and prospectus). Science. 1996;273:70–74
  78. Stephan RP, Sanders VM, Witte PL. Stage-specific alterations in murine lymphopoiesis with age. Int Immunol. 1996;8:509–518
  79. Radl J, Sepers JM, Skvaril F. Immunoglobulin patterns in humans over 95 years of age. Clin Exp Immunol. 1975;22:84–90
  80. Radl J. Animal model of human disease. Benign monoclonal gammopathy (idiopathic paraproteinemia). Am J Pathol. 1981;105:91–93
  81. Radl J. Age-related monoclonal gammopathies (Clinical lessons from the aging C57BL/6 mouse). Immunol Today. 1990;11:234–236
  82. Kyle RA. Monoclonal gammopathy of undetermined significance and solitary plasmacytoma. Implications for progression to overt myeloma. Hematol Oncol Clin North Am. 1997;11:71–87
  83. Thoman M, Weigle WO. Lymphokines and aging (Interleukin-2 production and activity in aged animals). J Immunol. 1981;127:2102–2106
  84. Ershler WB, Sun WH, Binkley N. Interleukin-6 and aging (Blood levels and mononuclear cell production increase with advancing age and in vitro production is modifiable by dietary restriction). Lymphokine Cytokine Res. 1993;12:225–230
  85. Ershler WB. Interleukin-6 (A cytokine for gerontologists). J Am Geriatr Soc. 1993;41:176–181
  86. Ershler WB, Keller ET. Age-associated increased IL-6 gene expression, late-life diseases and frailty. Ann Rev Med. 2000;51:245–270
  87. Ershler WB. The influence of an aging immune system on cancer incidence and progression. J Gerontol. 1993;48:B3–B7
  88. Miller RA. Aging and cancer (Another perspective). J Gerontol. 1993;48:B8–B10
  89. Covelli V, Mouton D, Mojo V, et al.  Inheritance of immune responsiveness, life span and disease incidence in interline crosses of mice selected for high or low multispecific antibody production. J Immunol. 1989;142:1224–1234
  90. Imai K, Matsuyama S, Miyake S, et al.  Natural cytotoxic activity of peripheral-blood lymphocytes and cancer incidence (An 11-year follow-up study of a general population). Lancet. 2000;356:1795–1799
  91. Weinberg RA. Oncogenes and the Molecular Origins of Cancer. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press; 1989;
  92. Korsemeyer SJ. Programmed cell death (Bcl-2). In:  DeVita VT,  Hellman S,  Rosenberg SA editor. Important Advances in Oncology. Philadelphia, PA: Lippincott; 1993;p. 19–28
  93. Vogelstein B, Fearon ER, Hamilton SR, et al.  Genetic alterations during colorectal tumor development. N Engl J Med. 1988;319:525–532
  94. James CD, Carlbom E, Dumanskji JP, et al.  Clonal genomic alterations in glioma malignancy stages. Cancer Res. 1988;48:5546–5551
  95. Boyle P, Leake R. Progress in understanding breast cancer (Epidemiological and biological interactions). Breast Cancer Res Treat. 1988;11:91–112
  96. Harris JR, Lippman ME, Veronesi U, et al.  Breast cancer. N Engl J Med. 1992;327:319–328 390–398, 473–480
  97. Carney DN. Biology of small cell lung cancer. Lancet. 1992;339:843–846
  98. Correa P. Biochemical and molecular methods in cancer epidemiology and prevention (The path between the laboratory and the population). Cancer Epidemiol Biomark Prev. 1993;2:85–88
  99. Vineis P. Epidemiological models of carcinogenesis (The example of bladder cancer). Cancer Epidemiol Biomark Prev. 1992;1:149–154
  100. el Azouzi M, Chung RY, Farmer GE, et al.  Lost of distinct regions on the short arm of chromosome 17 associated with tumorigenesis of human astrocytomas. Proc Natl Acad Sci U S A. 1989;86:7186–7190
  101. Aoyagi Y, Yokose T, Minami Y, et al.  Accumulation of losses of heterozygosity and multistep carcinogenesis in pulmonary adenocarcinoma. Cancer Res. 2001;61:7950–7954
  102. Linehan WM, Gnarra JR, Lerman MI, et al.  Genetic bases of renal cell cancer. In:  DeVita VT,  Hellman S,  Rosenberg SA editor. Important Advances in Oncology. Philadelphia, PA: Lippincott; 1993;p. 47–70
  103. Franco EL. Prognostic value of human papillomavirus in the survival of cervical cancer patients (An overview of the evidence). Cancer Epidemiol Biomark Prev. 1992;1:499–504
  104. Anisimov VN. Age as a factor of risk in multistage carcinogenesis. In:  Balducci L,  Lyman GH,  Ershler WB editor. Geriatric Oncology. Philadelphia, PA: Lippincott; 1992;p. 53–60
  105. Fernandez-Pol JA. Growth factors, oncogenes, antioncogenes and aging. In:  Balducci L,  Lyman GH,  Ershler WB editor. Comprehensive Geriatric Oncology. Philadelphia, PA: Harcourt; 1998;p. 179–196
  106. Stevens RG, Jones DY, Micozzi MS, et al.  Body iron stores and the risk of cancer. N Engl J Med. 1988;319:1047–1052
  107. Anisimov VN. Effect of age on dose-response relationship in carcinogenesis induced by single administration of N-methynitrosourea in female rats. J Cancer Res Clin Oncol. 1988;114:628–635
  108. Ward JM, Lynch P, Riggs C. Rapid development of hepatocellular neoplasms in aging male C3H/HeNcr mice given phenobarbital. Cancer Lett. 1988;39:9–18
  109. Ebbesen P. Reticulosarcoma and amyloid development in BALB/c mice inoculated with syngeneic cells from young and old donors. J Natl Cancer Inst. 1971;47:1241–1245
  110. Anisimov VN, Loktionov AS, Khavinson VK, et al.  Effect of low molecular weight factors of thymus and pineal gland on life span and spontaneous tumor development in female mice of different age. Mech Ageing Dev. 1989;49:245–257
  111. Kaldor JM, Day NE. Interpretation of epidemiological studies in the context of the multistage model of carcinogenesis. In:  Barrett JC editors. Mechanisms of Environmental Carcinogenesis. vol 2:Boca Raton, FL: CRC Press; 1987;p. 21–57
  112. Tantranond P, Karam F, Wang TY, et al.  Management of cutaneous squamous cell carcinoma in an elderly man. J Am Geriatr Soc. 1992;40:510–512
  113. Glass AG, Hoover RN. The emerging epidemic of melanoma and squamous cell carcinoma of the skin. JAMA. 1989;262:2097–2100
  114. Matoha MF, Cosgrove JW, Atak JR, et al.  Selective elevation of the c-myc transcript levels in the liver of the aging Fischer 344 rat. Biochem Biophys Res Commun. 1987;147:1–7
  115. Bohr VA, Evans MK, Fornace AJ. Biology of disease (DNA repair and its pathogenetic implications). Lab Invest. 1989;61:143–161
  116. Randerath K, Reddy MV, Disher RM. Age- and tissue-related DNA modifications in untreated rats (Detection by 32P-post-labeling assay and possible significance for spontaneous tumor induction and aging). Carcinogenesis. 1986;7:1615–1617
  117. Ershler WB, Stewart JA, Hacker MP, et al.  B16 murine melanoma and aging (Slower growth and longer survival in old mice). J Natl Cancer Inst. 1984;72:161–165
  118. Ershler WB, Moore AL, Shore H, et al.  Transfer of age-associated restrained tumor growth in mice by old to young bone marrow transplantation. Cancer Res. 1984;44:5677–5681
  119. Tsuda T, Kim YT, Siskind GW, et al.  Role of the thymus and T-cells in slow growth of B16 melanoma in old mice. Cancer Res. 1987;47:3097–3103
  120. Ershler WB. Guest Editorial (Why tumors grow more slowly in old people). J Natl Cancer Inst. 1986;77:837–839
  121. Simon SR, Ershler WB. Hormonal influences on growth of B16 murine melanoma. J Natl Cancer Inst. 1985;74:1085–1088
  122. Ershler WB, Berman E, Moore AL. B16 melanoma growth is slower, but pulmonary colonization is greater in calorie restricted mice. J Natl Cancer Inst. 1986;76:81–85
  123. Ershler WB, Gamelli RL, Moore AL, et al.  Experimental tumors and aging (Local factors that may account for the observed age advantage in the B16 murine melanoma model). Exp Gerontol. 1984;19:367–375
  124. Hadar E, Ershler WB, Kreisle RA, et al.  Lymphocyte-induced angiogenesis factor is produced by L3T4+ murine T lymphocytes, and its production declines with age. Cancer Immunol Immunother. 1988;26:31–37
  125. Kreisle RA, Stebler B, Ershler WB. Effect of host age on tumor associated angiogenesis in mice. J Natl Cancer Inst. 1990;82:44–47
  126. Fidler IJ, Gersten DM, Riggs CW. Relationship of host immune status to tumor cell arrest, distribution and survival in experimental metastases. Cancer. 1977;40:46–55
  127. Prehn RT, Lappe MA. An immunostimulation theory of tumor development. Transplant Rev. 1971;7:26–30

PII: S0093-7754(03)00663-8

doi: 10.1053/j.seminoncol.2003.12.025

Seminars in Oncology
Volume 31, Issue 2 , Pages 137-148 , April 2004