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Seminars in Oncology
Volume 31, Issue 2
, Pages 234-248
, April 2004
Breast cancer in older patients
References
- Cancer Statistics, 2003. CA Cancer J Clin. 2003;53:5–26
- The relation between survival and age at diagnosis in breast cancer. N Engl J Med. 1986;315:559–563
- . Effect of age on the survival of breast cancer patients. Eur J Cancer. 1997;33:425–428
- . Age as a prognostic factor in breast cancer. Cancer. 1986;57:2217–2221
- The influence of age on treatment choice and survival of elderly breast cancer patients in south-eastern Netherlands (A population- based study). Eur J Cancer. 1992;28A:1475–1480
- . Breast cancer in aging women. A population-based study of contrasts in stage, surgery, and survival. Cancer. 1989;63:976–981
- Survival following breast cancer surgery in the elderly. Cancer. 1981;47:2358–2363
-
Age and the risk of breast cancer recurrence.
Cancer Control. 1996;3:421–427
- Breast cancer in women 70 years of age or older. J Clin Oncol. 1996;13:2722–2730
- . Tumor characteristics and clinical outcome of elderly women with breast cancer. J Natl Cancer Inst. 2000;92:550–556
- Effect of age and comorbidity in postmenopausal breast cancer patients aged 55 years and older. JAMA. 2001;285:885–892
- . Age-related variation in the treatment and outcomes of patients with breast carcinoma. Cancer. 2000;88:369–374
- Stage at diagnosis of cancer varies with the age of the patient. J Am Geriatr Soc. 1986;34:20–26
- . The severity of breast cancer at diagnosis (A comparison of age and extent of disease in black and white women). Am J Public Health. 1986;76:779–782
- . Cancer stage-to-age relationship (Implications for cancer screening in the elderly). J Am Geriatr Soc. 1981;29:55–57
- . AGS Position Statement (Breast cancer screening in older women). J Am Geriatr Soc. 2000;48:842–844
- Patterns of care related to age of breast cancer patients. JAMA. 1987;257:2766–2770
- Age as a predictor of diagnostic and initial treatment intensity in newly diagnosed breast cancer patients. J Gerontol. 1989;44:M46–M50
-
.
Age at breast cancer diagnosis as a predictor of subsequent survival.
In:
Macieira-Coehlo A, Nordenskjold B editor. Cancer and Aging. Boca Raton, FL: CRC Press; 1990;p. 245–254
- Underutilization of breast-conserving surgery and radiation therapy among women with stage I or II breast cancer. JAMA. 1991;266:3433–3438
- A retrospective comparison of detection and treatment of breast cancer in young and elderly patients. Breast Cancer Res Treat. 1997;43:27–31
- Breast cancer care in old age (What we know, don’t know, and do). J Natl Cancer Inst. 1993;85:190–199
- The effect of age and comorbidity in the treatment of elderly women with nonmetastatic breast cancer. Arch Intern Med. 1996;156:85–90
- Causes for the undertreatment of elderly breast cancer patients (Tailoring treatments to individual patients). J Am Coll Surg. 2002;194:8–13
- . Physicians’ reasons for failing to deliver effective breast cancer care. A framework for underuse. Med Care. 2003;41:442–446
- . Cell proliferation and its relationship to clinical features and relapse in breast cancers. Cancer. 1981;48:974–979
- . Advanced stage and early relapse of breast carcinomas associated with high thymidine labeling indices. Cancer Res. 1979;39:4042–4047
- The influence of age on the DNA ploidy levels of breast-tumors. Eur J Cancer Clin Oncol. 1983;19:623–628
- Relationship of age and menopausal status to estrogen receptor content in primary carcinoma of the breast. Ann Surg. 1983;197:123–127
- . Assessment of malignancy potential in mammary carcinoma in elderly patients. Am J Clin Oncol. 1987;10:61–64
- Breast carcinoma in women over the age of 85 (Distinct histological pattern and androgen, oestrogen, and progesterone receptor status). Histopathology. 2003;42:120–127
- . Pure and mixed mucinous carcinomas of the breast (A clinicopathologic analysis of 61 cases with long-term follow-up). Hum Pathol. 1989;20:758–764
- . Age at diagnosis and outcome for women with ductal carcinoma-in-situ (A critical review of the literature). J Clin Oncol. 2002;20:2736–2744
- Differences in the pathologic and molecular features of intraductal breast carcinoma between younger and older women. Cancer. 2003;97:1393–1403
-
.
Health United States 1996–7 and Injury Chartbook. 1997;
Washington, DC, DHHS Publication No. (PHS) 97–1232
- . The effect of comorbidity on 3-year survival of women with primary breast cancer. Ann Intern Med. 1994;120:104–110
- . Competing causes of death for primary breast cancer. Ann Surg Oncol. 1998;5:368–375
- . The risk of mortality among older adults over an eight-year period. Gerontologist. 1995;35:150–161
- Constant hierarchic patterns of physical functioning across seven populations in five countries. Gerontologist. 1998;38:286–294
-
Predicting mortality from community surveys of older adults (The importance of self-rated functional ability).
Psychol Sci Soc Sci. 1997;52:S155–S166
- . Disability patterns in activities of daily living (Patterns of change and a hierarchy of disability). Am J Public Health. 1997;87:378–383
-
.
The relationship of self-rated function and self-rated health to concurrent functional ability, functional decline and mortality (Findings from the Nun Study).
Psychol Sci Soc Sci. 1996;51:S234–S241
-
.
Comorbidity in older women with breast cancer (An epidemiologic approach).
In:
Yancik R, Yates J editor. Cancer in the Elderly (Approaches to Early Detection and Treatment). New York, NY: Springer; 1989;p. 71–107
-
.
Comorbidity and functional status in older women with breast cancer (Implications for screening, treatment, and prognosis).
J Gerontol. 1992;47:24–31
- . Aging, comorbidity, and breast cancer survival (An epidemiologic view). Adv Exp Med Biol. 1993;330:1–11
- . Limiting comorbid conditions and breast cancer stage at diagnosis. J Gerontol A Biol Sci Med Sci. 2000;55:M593–M600
- . Determinants of cancer therapy in elderly patients. Cancer. 1993;72:594–601
- Surgical mortality among the elderly. An analysis of 4,050 operations (1970–1974). Clin Bull. 1978;8:139–142
- . Breast cancer in the elderly. Ann Surg. 1993;218:667–671
- . Tamoxifen as an alternative to surgical resection for selected geriatric patients with primary breast cancer. Arch Surg. 1989;124:548–550
- . Primary treatment of breast cancer in elderly women with tamoxifen. Clin Oncol. 1983;9:31–34
- Tamoxifen as primary treatment of breast cancer in elderly or frail patients (A practical management). BMJ. 1985;290:358
- A 10-year experience of tamoxifen as primary treatment of breast cancer in 100 elderly and frail patients. Eur J Surg Oncol. 1991;17:30–35
- Response of primary breast cancer to tamoxifen alone in elderly women. Tumori. 1991;77:328–330
- Tamoxifen as primary treatment of breast cancer in elderly patients. Neoplasma. 1996;43:43–45
- Should tamoxifen be a primary treatment choice for elderly breast cancer patients with locoregional disease?. Breast Cancer Res Treat. 1995;34:77–83
- Long-term follow-up of elderly patients with locoregional breast cancer treated with tamoxifen only. Br J Surg. 1991;78:213–217
- Tamoxifen as initial sole treatment of localized breast cancer in elderly women (A pilot study). BMJ. 1982;284:869–870
- Indications for primary tamoxifen therapy in elderly women with breast cancer. Br J Surg. 1992;79:1317–1320
- . Treatment of breast cancer in elderly patients. J Surg Oncol. 1995;60:80–82
- Comparison of mastectomy with tamoxifen for treating elderly patients with operable breast cancer. BMJ. 1988;297:511–514
- Prospective randomized trial of tamoxifen versus surgery in elderly patients with breast cancer. Lancet. 1988;1:679–681
- Prospective randomized trial of tamoxifen vs surgery in elderly patients with breast cancer. Eur J Surg Oncol. 1994;20:207–214
- Breast cancer in elderly women: A Cancer Research Campaign trial comparing treatment with tamoxifen and optimal surgery with tamoxifen alone. The Elderly Breast Cancer Working Party. Br J Surg. 1991;78:591–594
- Tamoxifen or surgery plus tamoxifen as primary treatment for elderly patients with operable breast cancer: The G.R.E.T.A. Trial. Group for Research on Endocrine Therapy in the Elderly. Anticancer Res. 1994;14:2197–2200
- Tamoxifen alone versus adjuvant tamoxifen for operable breast cancer of the elderly (Long-term results of the phase III randomized controlled multicenter GRETA trial). Ann Oncol. 2003;14:414–420
- Breast cancer in elderly women (A retrospective analysis of combined treatment with tamoxifen and once-weekly irradiation). Int J Radiat Oncol Biol Phys. 1995;31:783–789
- Randomized clinical trial to assess the effectiveness of breast irradiation following lumpectomy and axillary dissection for node- negative breast cancer. J Natl Cancer Inst. 1992;84:683–689
- Treatment of breast cancer among elderly women with segmental mastectomy or segmental mastectomy plus postoperative radiotherapy. Int J Radiat Oncol Biol Phys. 1988;15:263–270
- . Wide local excision as the sole primary treatment in elderly patients with carcinoma of the breast. Br J Surg. 1989;76:898–900
- Radiotherapy after breast-preserving surgery in women with localized cancer of the breast. N Engl J Med. 1993;328:1587–1591
- Ten-year results of a randomized clinical trial comparing radical mastectomy and total mastectomy with or without radiation. N Engl J Med. 1985;312:674–681
- Twenty-five-year follow-up of a randomized trial comparing radical mastectomy, total mastectomy, and total mastectomy followed by irradiation. N Engl J Med. 2002;347:567–575
- Value of axillary dissection in addition to lumpectomy and radiotherapy in early breast cancer. Lancet. 1992;339:1245–1248
- Sequelae of axillary lymph node dissection in older women with stage 1 and 2 breast cancer. Cancer. 2002;95:2445–2454
- Predictors of long-term outcomes in older breast cancer survivors (Perceptions versus patterns of care). J Clin Oncol. 2003;21:855–863
- Sentinel lymph node biopsy for breast cancer (A suitable alternative to routine axillary dissection in multi-institutional practice when optimal technique is used). J Clin Oncol. 2000;18:2560–2566
- Prospective observational study of sentinel lymphadenectomy without further axillary dissection in patients with sentinel node-negative breast cancer. J Clin Oncol. 2000;18:2553–2559
- Surgical resection plus tamoxifen as treatment of breast cancer in elderly patients (A retrospective study). Eur J Cancer. 1993;29A:2080–2082
- Long-term follow-up of elderly patients with operable breast cancer treated with surgery without axillary dissection plus adjuvant tamoxifen. Br J Cancer. 1995;72:1251–1255
- Is axillary lymph node dissection necessary in elderly patients with breast carcinoma who have a clinically uninvolved axilla?. Cancer. 2003;97:1156–1163
- . Radiotherpay after lumpectomy for breast cancer in very old women. Am J Clin Oncol. 2002;25:48–49
- Tamoxifen with and without radiation after partial mastectomy in patients with involved nodes. Int J Radiat Oncol Biol Phys. 1995;31:777–781
-
Preliminary results of a randomized study of tamoxifen +/- breast radiation in T1/2 N0 disease in women over 50 years of age.
Proc Am Soc Clin Oncol. 2001;20:24a;
(abstr)
-
Comparison of lumpectomy plus tamoxifen with and without radiotherpay in women 70 years of age or older who have clinical stage I, estrogen receptor positive (ER+) breast carcinoma.
Proc Am Soc Clin Oncol. 2001;20:24a;
(abstr)
- . Once weekly irradiation in breast cancer. Int J Radiat Oncol Biol Phys. 1987;13:551–555
-
.
Systemic therapy for older women with breast cancer.
Oncology NY. 2001;15:280–291
- . What threshold for adjuvant therapy in older breast cancer patients?. J Clin Oncol. 2000;18:1709–1717
- . Understanding the utility of adjuvant systemic therapy for primary breast cancer. J Clin Oncol. 2001;19:972–979
- Computer program to assist in making decisions about adjuvant therapy for women with early breast cancer. J Clin Oncol. 2001;19:980–991
- . Anonymous: Tamoxifen for early breast cancer: An overview of the randomized trials. Lancet. 1998;351:1451–1467
- Anastrozole alone or in combination with tamoxifen versus tamoxifen alone for adjuvant treatment of postmenopausal women with early breast cancer (First results of the ATAC randomised trial). Lancet. 2002;359:2131–2139
- . Anonymous: Polychemotherapy for early breast cancer: An overview of the randomized trials. Lancet. 1998;352:930–942
- Risk factors for doxorubicin-induced congestive heart failure. Ann Intern Med. 1979;91:710–717
- . Adjuvant therapy of primary breast cancer (a review of key findings from the 7th international conference, St Gallen, February 2001). Oncologist. 2001;6:376–385
- . Increase of chemotherapy use in older women with breast carcinoma from 1991 to 1996. Cancer. 2001;92:730–737
- Mortality during adjuvant treatment of early breast cancer with cyclophosphamide, methotrexate, and fluorouracil. Lancet. 1999;354:130–131
- Burdens and benefits of adjuvant cyclophosphamide, methotrexate, and fluorouracil and tamoxifen for elderly patients with breast cancer (The International Breast Cancer Study Groups Trial VII). J Clin Oncol. 2000;18:1412–1422
- Postoperative chemotherapy and tamoxifen compared with tamoxifen alone in the treatment of positive-node breast cancer patients aged 50 years and older with tumors responsive to tamoxifen (Results from the National Surgical Adjuvant Breast and Bowel Project B-16). J Clin Oncol. 1990;8:1005–1018
- Two months of doxorubicin-cyclophosphamide with and without interval reinduction therapy compared with 6 months of cyclophosphamide, methotrexate, and fluorouracil in positive-node breast cancer patients with tamoxifen-nonresponsive tumors (Results from the National Surgical Adjuvant Breast and Bowel Project B-15). J Clin Oncol. 1990;8:1483–1496
- Epirubicin plus tamoxifen versus tamoxifen alone in node-positive postmenopausal patients with breast cancer (A randomized trial of the International Collaborative Cancer Group). J Clin Oncol. 1999;17:1988–1998
-
.
Treatment of metastatic breast cancer.
In:
Harris JR, Lippman ME, Morrow M editor. Diseases of the Breast. Philadelphia, PA: Lippincott Williams & Wilkins; 2000;p. 749–797
- Anastrozole is superior to tamoxifen as first-line therapy in hormone receptor positive advanced breast carcinoma. Cancer. 2001;92:2247–2258
- Superior efficacy of letrozole versus tamoxifen as first-line therapy for postmenopausal women with advanced breast cancer (Results of a phase III study of the international letrozole breast cancer group). J Clin Oncol. 2001;19:2596–2606
- Multicenter, phase II trial of exemestane as third-line hormonal therapy of postmenopausal women with metastatic breast cancer. Aromasin Study Group. J Clin Oncol. 1999;17:3418–3425
-
Exemestane improves survival compared with megoestrol acetate in postmenopausal patients with advanced breast cancer who have failed on tamoxifen (Results of a double-blind randomised phase III trial).
Eur J Cancer. 2000;36:S86–S87
- Double-blind, randomized trial comparing the efficacy and tolerability of fulvestrant versus anastrozole in postmenopausal women with advanced breast cancer progressing on prior endocrine therapy (Results of a North American trial). J Clin Oncol. 2002;20:3386–3395
-
.
Sequencing of endocrine therapies in breast cancer-Integration of recent data.
Breast Cancer Res Treat. 2002;75:S27–S32
- Combination chemotherapy compared to tamoxifen as initial therapy for stage IV breast cancer in elderly women. Ann Intern Med. 1986;104:455–461
- . Anonymous (A randomized trial in postmenopausal patients with advanced breast cancer comparing endocrine and cytotoxic therapy given sequentially or in combination). J Clin Oncol. 1986;4:186–193
-
.
A study of excess hematologic toxicity in elderly patients treated on chemotherapy protocols.
In:
Yancik R editors. Cancer in the Elderly (Approaches to Early Detection and Management). New York, NY: Springer-Verlag; 1989;p. 149–161
- . Cyclophosphamide, methotrexate, and 5-fluorouracil chemotherapy in women more than 65 years old with advanced breast cancer (The elimination of age trends in toxicity by using doses based on creatinine clearance). J Clin Oncol. 1984;2:1404–1413
- Chemotherapy of metastatic breast cancer in the elderly. The Piedmont Oncology Association experience. JAMA. 1992;268:57–62
- Doxorubicin-based chemotherapy in elderly patients with metastatic breast cancer. Tolerance and outcome. Arch Intern Med. 1996;156:882–888
- Treatment tolerance of elderly cancer patients entered onto phase II clinical trials (An Illinois Cancer Center study). J Clin Oncol. 1994;12:2447–2452
- Doxorubicin-induced congestive heart failure in elderly patients with metastatic breast cancer, with long-term follow-up (The M.D. Anderson experience). Cancer Chemother Pharmacol. 1999;43:471–478
- . Population-based assessment of hospitalizations for toxicity from chemotherapy in older women with breast cancer. J Clin Oncol. 2002;20:4636–4642
- . Review of docetaxel (Taxotere), a highly active new agent for the treatment of metastatic breast cancer. Semin Oncol. 1995;22(suppl 4):17–21
- . Single-agent paclitaxel for the treatment of breast cancer (An overview). Semin Oncol. 1996;23(suppl 1):4–9
- Weekly paclitaxel in women age 65 and above with metastatic breast cancer. Breast Cancer Res Treat. 2002;73:85–88
- Pharmacokinetics and tolerance of vinorelbine in elderly patients with metastatic breast cancer. Eur J Cancer. 1997;33:301–303
- Vinorelbine as first-line chemotherapy for advanced breast cancer in women 60 years of age or older. Ann Oncol. 1999;10:397–402
- Treatment of advanced breast cancer with sterically stabilized liposomal doxorubicin (Results of a multicenter phase II trial). J Clin Oncol. 1997;15:3185–3191
-
A multicenter phase II trial of Xeloda (capecitabine) in paclitaxel-refractory metastatic breast cancer.
Proc Am Soc Clin Oncol. 1998;17:125a;
(abstr)
- Cardiac dysfunction in the trastuzumab clinical trials experience. J Clin Oncol. 2002;20:1215–1221
-
Efficacy and safety of HerceptinTM (humanized anti-HER2 antibody) as a single agent in 222 women with HER2 overexpression who relapsed following chemotherpay for metastatic breast cancer.
Proc Am Soc Clin Oncol. 1998;17:97a;
(abstr)
-
First-line, non-hormonal, treatment of women with HER2 overexpressing metastatic breast cancer with Herceptin (trastuzumab, humanized anti-HER2 antibody).
Proc Am Soc Clin Oncol. 2000;19:71a;
(abstr)
- Weekly trastuzumab and paclitaxel therapy for metastatic breast cancer with analysis of efficacy by HER2 immunophenotype and gene amplification. J Clin Oncol. 2001;19:2587–2595
- Clinical activity of trastuzumab and vinorelbine in women with HER2-overexpressing metastatic breast cancer. J Clin Oncol. 2001;19:2722–2730
- American Society of Clinical Oncology guideline on the role of bisphosphonates in breast cancer. American Society of Clinical Oncology Bisphosphonates Expert Panel. J Clin Oncol. 2000;18:1378–1391
- Randomized phase III trial evaluating the role of erythropoietin in the prevention of chemotherapy-induced anemia. J Clin Oncol. 1997;15:2715–2721
- Representation of older patients in cancer treatment trials. Cancer. 1994;74:2208–2214
- Underrepresentation of patients 65 years of age or older in cancer-treatment trials. N Engl J Med. 1999;341:2061–2067
PII: S0093-7754(03)00671-7
doi: 10.1053/j.seminoncol.2003.12.033
© 2004 Elsevier Inc. All rights reserved.
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Seminars in Oncology
Volume 31, Issue 2
, Pages 234-248
, April 2004
