Seminars in Oncology
Volume 30, Issue 2 , Pages 132-135 , April 2003

The malignant clone in Waldenstrom's macroglobulinemia

References 

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  2. Duong Van Huyen J-P, Molina T, Delmer A, et al.  Splenic marginal zone mymphoma with or without plasmacytic differentiation. Am J Surg Pathol. 2000;24:1581–1592
  3. Morel P, Monconduit M, Jacomy D, et al.  Prognostic factors in Waldenström's macroglobulinemia: A report on 232 patients with the description of a new scoring system and its validation on 253 other patients. Blood. 2000;96:852–858
  4. Diebold J, Molina T, Tisser F, et al.  Waldenström's macrogobulinemia is a biological syndrome which may occur during the evolution of different types of low grade B cell lymphoma. Leukemia. 1999;13:1637–1638
  5. Owen RG, Johnson SA, Morgan GJ. Waldenström's macroglobulinaemia: Laboratory diagnosis and treatment. Hematol Oncol. 2000;18:41–49
  6. Jensen GS, Andrews EJ, Mant MJ, et al.  Transitions in CD45 isoform expression indicate continuous differentiation of a monoclonal CD5+CD11b+ B lineage in Waldenstrom's macroglobulinemia. Am J Hematol. 1991;37:20–30
  7. Wagner SD, Martinelli V, Luzzato L. Similar patterns of Vk usage but different degrees of somatic mutation in hairy cell leukemia, prolymphocytic leukemia, Waldenström's macroglobulinemia ad myeloma. Blood. 1994;83:3647–3653
  8. Aoki H, Takishita M, Kosaka M, et al.  Frequent somatic mutations in D and/or Jh segments of Ig gene in Waldenström's macroglobulinemia and chronic lymphocytic leukemia (CLL) with Ritchter's syndrome but not in commmon CLL. Blood. 1995;85:1913–1919
  9. Ciric B, VenKeulen V, Rodriguez M, et al.  Clonal evolution in Waldenström's macroglobulinemia highlights the functional role of B cell receptor. Blood. 2001;97:321–323
  10. Jensen GS, Poppema S, Mant MJ, et al.  Transition in CD45 isoform expression during differentiation of normal and abnormal B cells. Int Immunol. 1989;1:229–236
  11. Pilarski LM, Andrews EJ, Serra HM, et al.  Abnormalities in lymphocyte profile and specificity repertoire of patients with Waldenstroms macroglobulinemia, multiple myeloma and I IgM monoclonal gammopathy of undetermined significance. Am J Hematol. 1989;30:53–60
  12. Pilarski LM, Jensen GS. Monoclonal circulating B cells in multiple myeloma: A continuously differentiating possibly invasive population as defined by expression of CD45 isoforms and adhesion molecules. Hematol Oncol Clin North Am. 1992;6:297–322
  13. Pilarski LM, Mant MJ, Ruether BA. Review: Analysis of immunodeficiency in multiple myeloma: Observations and hypothesis. J Clin Lab Anal. 1987;1:214–288
  14. Sahota SS, Forconi F, Ottensmeier CH, et al.  Typical Waldenstrom macroglobulinemia is derived from a B-cell arrested after cessation of somatic mutation but prior to isotype switch events. Blood. 2002;100:1505–1507
  15. Sahota SS, Garand R, Mahroof R, et al.  V(H) gene analysis of IgM-secreting myeloma indicates an origin from a memory cell undergoing isotype switch events. Blood. 1999;94:1070–1076
  16. Sahota SS, Garand R, Bataille R, et al.  VH gene analysis of clonally related IgM and IgG from human lymphoplasmacytoid B-cell tumors with chronic lymphocytic leukemia features and high serum monoclonal IgG. Blood. 1998;91:238–243

☆ Supported by a Smokler Award from the Research Fund for Waldenström's.

☆☆ Address reprint requests to Linda M. Pilarski, PhD, Department of Oncology, University of Alberta and Cross Cancer Institute, 11560 University Ave, Edmonton, Alberta, T6G 1Z2, Canada.

★ 0093-7754/03/3002-0026$30.00/0

PII: S0093-7754(03)70063-3

doi: 10.1053/sonc.2003.50061

Seminars in Oncology
Volume 30, Issue 2 , Pages 132-135 , April 2003

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