Seminars in Oncology
Volume 31, Issue 4 , Pages 554-565 , August 2004

Treatment of localized esophageal cancer

  • Baruch Brenner

      Affiliations

    • Institute of Oncology, Rabin Medical Center, Beilinson Campus, Petah Tiqva and the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    • Corresponding Author InformationAddress reprint requests to Baruch Brenner, MD, Institute of Oncology, Rabin Medical Center, Beilinson Campus, Petah Tiqva 49100, Israel
    • ,
  • David H. Ilson

      Affiliations

    • Gastrointestinal Oncology Service, Department of Medicine, and the Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, and the Weill School of Medicine, Cornell University, New York, NY, USA
    • ,
  • Bruce D. Minsky

      Affiliations

    • Gastrointestinal Oncology Service, Department of Medicine, and the Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, and the Weill School of Medicine, Cornell University, New York, NY, USA

References 

  1. Jemal A, Tiwari RC, Murray T, Samuels A, et al.  Cancer statistics, 2004. CA Cancer J Clin. 2004;54:8–29
  2. Kelsen D. Preoperative chemoradiotherapy for esophageal cancer. J Clin Oncol. 2001;19:283–285
  3. Coia LR, Minsky BD, John MJ, et al.  The evaluation and treatment of patients receiving radiation therapy for carcinoma of the esophagus (Results of the 1992–1994 Patterns of Care Study). Cancer. 1999;85:2499–2505
  4. Chu KM, Law SY, Fok M, et al.  A prospective randomized comparison of transhiatal and transthoracic resection for lower-third esophageal carcinoma. Am J Surg. 1997;174:320–324
  5. Skinner DB. En bloc resection for neoplasms of the esophagus and cardia. J Thorac Cardiovasc Surg. 1983;85:59–71
  6. Isono K, Ochiai T, Okuyama K, et al.  The treatment of lymph node metastasis from esophageal cancer by extensive lymphadenectomy. Jpn J Surg. 1990;20:151–157
  7. Hulscher JB, Tijssen JG, Obertop H, et al.  Transthoracic versus transhiatal resection for carcinoma of the esophagus (A meta-analysis). Ann Thorac Surg. 2001;72:306–313
  8. Goldminc M, Maddern G, Le Prise E, et al.  Oesophagectomy by a transhiatal approach or thoracotomy (A prospective randomized trial). Br J Surg. 1993;80:367–370
  9. Hulscher JBF, van Sandick JW, de Boer AGEM, et al.  Extended transthoracic resection compared with limited transhiatal resection for adenocarcinoma of the esophagus. N Engl J Med. 2002;347:1662–1669
  10. Lerut T, De Leyn P, Coosemans W, et al.  Surgical strategies in esophageal carcinoma with emphasis on radical lymphadenectomy. Ann Surg. 1992;216:583–590
  11. Hagen JA, Peters JH, DeMeester TR. Superiority of extended en bloc esophagogastrectomy for carcinoma of the lower esophagus and cardia. J Thorac Cardiovasc Surg. 1993;106:850–858
  12. Altorki NK. The rationale for radical resection. Surg Oncol Clin North Am. 1999;8:295–305
  13. Nishihira T, Hirayama K, Mori S. A prospective randomized trial of extended cervical and superior mediastinal lymphadenectomy for carcinoma of the thoracic esophagus. Am J Surg. 1998;175:47–51
  14. Kato H, Watanabe H, Tachimori Y, et al.  Evaluation of neck lymph node dissection for thoracic esophageal carcinoma. Ann Thorac Surg. 1991;51:931–935
  15. Sun DR. Ten-year follow-up of esophageal cancer treated by radical radiation therapy (Analysis of 869 patients). Int J Radiat Oncol Biol Phys. 1989;16:329–334
  16. Okawa T, Kita M, Tanaka M, et al.  Results of radiotherapy for inoperable locally advanced esophageal cancer. Int J Radiat Oncol Biol Phys. 1989;17:49–54
  17. Nemoto K, Yamada S, Hareyama M, et al.  Radiation therapy for superficial esophageal cancer (A comparison of radiotherapy methods). Int J Radiat Oncol Biol Phys. 2001;50:639–644
  18. Sykes AJ, Burt PA, Slevin NJ, et al.  Radical radiotherapy for carcinoma of the oesophagus (An effective alternative to surgery). Radiother Oncol. 1998;48:15–21
  19. Nygaard K, Hagen S, Hansen HS, et al.  Pre-operative radiotherapy prolongs survival in operable esophageal carcinoma (A randomized, multicenter study of pre-operative radiotherapy and chemotherapy. The second Scandinavian trial in esophageal cancer). World J Surg. 1992;16:1104–1110
  20. Arnott SJ, Duncan W, Kerr GR, et al.  Low dose preoperative radiotherapy for carcinoma of the oesophagus (Results of a randomized clinical trial). Radiother Oncol. 1992;24:108–113
  21. Gignoux M, Roussel A, Paillot B, et al.  The value of preoperative radiotherapy in esophageal cancer (Results of a study of the EORTC). World J Surg. 1987;11:426–432
  22. Huang GJ, Gu XZ, Wang LJ, et al.  Combined preoperative irradiation and surgery for esophageal carcinoma. In:  Delarue NC editors. International Trends in General Thoracic Surgery. St Louis, MO: Mosby; 1988;p. 315–318
  23. Launois B, Delarue D, Campion JP, et al.  Preoperative radiotherapy for carcinoma of the esophagus. Surg Gynecol Obstet. 1981;153:690–692
  24. Wang M, Gu XZ, Yin WB, et al.  Randomized clinical trial on the combination of preoperative irradiation and surgery in the treatment of esophageal carcinoma (Report on 206 patients). Int J Radiat Oncol Biol Phys. 1989;16:325–327
  25. Arnott SJ, Duncan W, Gignoux M, et al.  Oesophageal Cancer Collaborative Group   Preoperative radiotherapy in esophageal carcinoma (A meta-analysis using individual patient data). Int J Radiat Oncol Biol Phys. 1998;41:579–583
  26. Yamamoto M, Yamashita T, Matsubara T, et al.  Reevaluation of postoperative radiotherapy for thoracic esophageal carcinoma. Int J Radiat Oncol Biol Phys. 1997;37:75–78
  27. Hosokawa M, Shirato H, Ohara M, et al.  Intraoperative radiation therapy to the upper mediastinum and nerve-sparing three-field lymphadenectomy followed by external beam radiotherapy for patients with thoracic esophageal carcinoma. Cancer. 1999;86:6–13
  28. Fok M, Sham JS, Choy D, et al.  Postoperative radiotherapy for carcinoma of the esophagus (A prospective, randomized controlled study). Surgery. 1993;113:138–147
  29. Teniere P, Hay JM, Fingerhut A, et al.  Postoperative radiation therapy does not increase survival after curative resection for squamous cell carcinoma of the middle and lower esophagus as shown by a multicenter controlled trial. French University Association for Surgical Research. Surg Gynecol Obstet. 1991;173:123–130
  30. Mandard AM, Chasle J, Marnay J, et al.  Autopsy findings in 111 cases of esophageal cancer. Cancer. 1981;48:329–335
  31. Nanus DM, Kelsen DP, Niedzwiecki D, et al.  Flow cytometry as a predictive indicator in patients with operable gastric cancer. J Clin Oncol. 1989;7:1105–1112
  32. Forastiere AA, Gennis M, Orringer MB, et al.  Cisplatin, vinblastine, and mitoguazone chemotherapy for epidermoid and adenocarcinoma of the esophagus. J Clin Oncol. 1987;5:1143–1149
  33. Carey RW, Hilgenberg AD, Wilkins EW, et al.  Long-term follow-up of neoadjuvant chemotherapy with 5-fluorouracil and cisplatin with surgical resection and possible postoperative radiotherapy and/or chemotherapy in squamous cell carcinoma of the esophagus. Cancer Invest. 1993;11:99–105
  34. Ajani JA, Ryan B, Rich TA, et al.  Prolonged chemotherapy for localized squamous carcinoma of the oesophagus. Eur J Cancer. 1992;28A:880–884
  35. Kelsen DP, Ginsberg R, Pajak T, et al.  Chemotherapy followed by surgery compared with surgery alone for localized esophageal cancer. N Engl J Med. 1998;339:1979–1984
  36. Kok TC, Lanschot JV, Siersema PD, et al.  Neoadjuvant chemotherapy in operable esophageal squamous cell cancer (Final report of a phase III multi-center randomized control trial). Proc Am Soc Clin Oncol. 1997;16:277; (abstr)
  37. Roth JA, Pass HI, Flanagan MM, et al.  Randomized clinical trial of preoperative and postoperative adjuvant chemotherapy with cisplatin, vindesine, and bleomycin for carcinoma of the esophagus. J Thorac Cardiovasc Surg. 1988;96:242–248
  38. Schlag P  CAO Esophageal Cancer Study Group . Randomized trial of preoperative chemotherapy in squamous cell cancer of the esophagus. Chirurg. 1992;63:709–714 [in German]
  39. MRCOCW . Surgical resection with or without preoperative chemotherapy in oesophageal cancer (A randomised controlled trial). Lancet. 2002;359:1727–1733
  40. Allum W, Cunningham D, Weeden S, et al.  Perioperative chemotherapy and operable gastric and lower esophageal cancer (A randomized, controlled trial). Proc Am Soc Clin Oncol. 2003;22:249; (the MAGIC trial ISRCNT93793971), (abstr 998)
  41. Group JEO Japanese Esophageal Oncology Group . A comparison of chemotherapy and radiotherapy as adjuvant treatment to surgery for esophageal carcinoma. Chest. 1993;104:203–220
  42. Lizuka T, Isono K, Watanabe H, et al.  A randomized trial comparing surgery to surgery plus postoperative chemotherapy for localized squamous carcinoma of the thoracic esophagus (The Japan Clinical Oncology Group (JCOG) Study). Proc Am Soc Clin Oncol. 1998;17:282; (abstr)
  43. Ando N, Iizuka T, Ide H, et al.  A randomized trial of surgery alone vs surgery plus postoperative chemotherapy with cisplatin and 5-fluorouracil for localized squamous carcinoma of the thoracic esophagus (The Japan Clinical Oncology Group Study (JCOG 9204)). Proc Am Soc Clin Oncol. 1999;18:269a; (abstr)
  44. Armanios MY, Xu R, Forestiere A, et al.  Phase II adjuvant chemotherapy for resected adenocarcinoma of the esophagus, gastroesophageal (GE) junction and cardia (E8296) (A trial of the Eastern Cooperative Oncology Group). Proc Am Soc Clin Oncol. 2003;22:296; (abstr 1190)
  45. Coia LR, Engstrom PF, Paul AR, et al.  Long-term results of infusional 5-FU, mitomycin-C and radiation as primary management of esophageal carcinoma. Int J Radiat Oncol Biol Phys. 1991;20:29–36
  46. Valerdi JJ, Tejedor M, Illarramendi JJ, et al.  Neoadjuvant chemotherapy and radiotherapy in locally advanced esophagus carcinoma (Long-term results). Int J Radiat Oncol Biol Phys. 1993;27:843–847
  47. Herskovic A, Martz K, Al-Sarraf M, et al.  Combined chemotherapy and radiotherapy compared with radiotherapy alone in patients with cancer of the esophagus. N Engl J Med. 1992;326:1593–1598
  48. Al-Sarraf M, Martz K, Herskovic A, et al.  Progress report of combined chemoradiotherapy versus radiotherapy alone in patients with esophageal cancer (An intergroup study). J Clin Oncol. 1997;15:277–284
  49. Araujo CM, Souhami L, Gil RA, et al.  A randomized trial comparing radiation therapy versus concomitant radiation therapy and chemotherapy in carcinoma of the thoracic esophagus. Cancer. 1991;67:2258–2261
  50. Cooper JS, Guo MD, Herskovic A, et al.  Radiation Therapy Oncology Group   Chemoradiotherapy of locally advanced esophageal cancer (Long-term follow-up of a prospective randomized trial (RTOG 85-01)). JAMA. 1999;281:1623–1627
  51. Roussel A, Jacob JH, Haegele P, et al.  Controlled clinical trial for the treatment of patients with inoperable esophageal carcinoma (A study of the EORTC Gastrointestinal Tract Cancer Cooperative Group). Recent Results Cancer Res. 1988;110:21–29
  52. Slabber CF, Nel JS, Schoeman L, et al.  A randomized study of radiotherapy alone versus radiotherapy plus 5-fluorouracil and platinum in patients with inoperable, locally advanced squamous cancer of the esophagus. Am J Clin Oncol. 1998;21:462–465
  53. Smith TJ, Ryan LM, Douglass HOJ, et al.  Combined chemoradiotherapy vs. radiotherapy alone for early stage squamous cell carcinoma of the esophagus (A study of the Eastern Cooperative Oncology Group). Int J Radiat Oncol Biol Phys. 1998;42:269–276
  54. Rebecca WO, Richard MA. Combined chemotherapy and radiotherapy (without surgery) compared with radiotherapy alone in localized carcinoma of the esophagus. Cochrane Database Syst Rev. 2003;2003: CD002092
  55. Coia LR, Minsky BD, Berkey BA, et al.  Outcome of patients receiving radiation for cancer of the esophagus (Results of the 1992–1994 Patterns of Care Study). J Clin Oncol. 2000;18:455–462
  56. Minsky BD, Pajak TF, Ginsberg RJ, et al.  INT 0123 (Radiation Therapy Oncology Group 94-05) phase III trial of combined-modality therapy for esophageal cancer (High-dose versus standard-dose radiation therapy). J Clin Oncol. 2002;20:1167–1174
  57. Jacob JH, Langlois C, et al.  Definitive concurrent chemo-radiation therapy (CRT) in squamous cell carcinoma of the esophagus (SCCE) (Preliminary results of a French randomized trial comparing standard vs. split course irradiation (FNCLCC-FFCD 9305)). Proc Am Soc Clin Oncol. 1999;270: SJ (abstr)
  58. Minsky BD, Neuberg D, Kelsen DP, et al.  Final report of Intergroup trial 0122 (ECOG PE-289, RTOG 90-12) (Phase II trial of neoadjuvant chemotherapy plus concurrent chemotherapy and high-dose radiation for squamous cell carcinoma of the esophagus). Int J Radiat Oncol Biol Phys. 1999;43:517–523
  59. Bains MS, Stojadinovic A, Minsky B, et al.  A phase II trial of preoperative combined-modality therapy for localized esophageal carcinoma (Initial results). J Thorac Cardiovasc Surg. 2002;124:270–277
  60. Goldberg M, Lampert C, Colarusso P, et al.  Survival following intensive preoperative combined modality therapy with paclitaxel, cisplatin, 5-fluorouracil, and radiation in resectable esophageal carcinoma (A phase I report). Proc Am Soc Clin Oncol. 2002;21:154a; (abstr 612)
  61. Ilson DH, Bains M, Kelsen DP, et al.  Phase I trial of escalating-dose irinotecan given weekly with cisplatin and consurrent radiothrrapy in locally advanced esophageal cancer. J Clin Oncol. 2003;21:2926–2932
  62. Jager J, Langendijk H, Pannebakker M, et al.  A single session of intraluminal brachytherapy in palliation of esophageal cancer. Radiother Oncol. 1995;37:237–240
  63. Calais G, Dorval E, Louisot P, et al.  Radiotherapy with high dose rate brachytherapy boost and concomitant chemotherapy for stages IIB and III esophageal carcinoma (Results of a pilot study). Int J Radiat Oncol Biol Phys. 1997;38:769–775
  64. Sur M, Sur R, Cooper K, et al.  Morphologic alterations in esophageal squamous cell carcinoma after preoperative high dose rate intraluminal brachytherapy. Cancer. 1996;77:2200–2205
  65. Gaspar LE, Qian C, Kocha WI, et al.  A phase I/II study of external beam radiation, brachytherapy and concurrent chemotherapy in localized cancer of the esophagus (RTOG 92-07) (Preliminary toxicity report). Int J Radiat Oncol Biol Phys. 1997;37:593–599
  66. Shi XH, Yao W, Liu TF. Late course accelerated fractionation in radiotherapy of esophageal carcinoma. Radiother Oncol. 1999;51:21–26
  67. Kim JH, Choi EK, Kim SB, et al.  Preoperative hyperfractionated radiotherapy with concurrent chemotherapy in resectable esophageal cancer. Int J Radiat Oncol Biol Phys. 2001;50:1–12
  68. Ajani JA, Komaki R, Putnam JB, et al.  A three-step strategy of induction chemotherapy then chemoradiation followed by surgery in patients with potentially resectable carcinoma of the esophagus or gastroesophageal junction. Cancer. 2001;92:279–286
  69. Safran H, Gaissert H, Akerman P, et al.  Paclitaxel, cisplatin, and concurrent radiation for esophageal cancer. Cancer Invest. 2001;19:1–7
  70. Font A, Garcia-Alfonso P, Arellano A, et al.  Preoperative combined multimodal therapy with docetaxel plus 5-fluorouracil and concurrent hyperfractionated radiotherapy for locally advanced esophageal cancer. Proc Am Soc Clin Oncol. 2002;21:128b; (abstr)
  71. Anderson S, Ilson D, Bains M, et al.  Phase I trial of cisplatin and escalating dose irinotecan given weekly with concurrent radiation in locally advanced esophageal cancer. Proc Am Soc Clin Oncol. 2001;20:158a; (abstr)
  72. Mauer A, Haraf D, Ferguson M, et al.  Docetaxel-based combined modality therapy for locally advanced carcinoma of the esophagus and gastric cardia. Proc Am Soc Clin Oncol. 2000;19: (abstr)
  73. Urba SG, Orringer MB, Turrisi A, et al.  A randomized trial of preoperative chemoradiation versus surgery alone in patients with locoregional esophageal carcinoma. J Clin Oncol. 2001;19:305–313
  74. Walsh TN, Noonan N, Hollywood D, et al.  A comparison of multimodal therapy and surgery for esophageal adenocarcinoma. N Engl J Med. 1996;335:462–467
  75. Bosset JF, Gignoux M, Triboulet JP, et al.  Chemoradiotherapy followed by surgery compared with surgery alone in squamous-cell cancer of the esophagus. N Engl J Med. 1997;337:161–168
  76. Burmeister BH, Smithers BM, Fitzgerald L, et al.  A randomized phase III trial of preoperative chemoradiation followed by surgery (CR-S) versus surgery alone (S) for localized resectable cancer of the esophagus. Proc Am Soc Clin Oncol. 2002;21:130a; (abstr 518)
  77. Bedenne L, Michel P, Bouche O, et al.  Randomized phase III trial in locally advanced esophageal cancer (Radiochemotherapy followed by surgery versus radiochemotherapy alone (FFCD 9102)). Proc Am Soc Clin Oncol. 2002;21:130a; (abstr)
  78. Stahl M, Wilke H, Walz MK, et al.  In: Randomized phase III trial in locally advanced squamous cell carcinoma (SCC) of the esophagus (Chemoradiation with and without surgery). Chicago, IL: Am Soc Clin Oncol; 2003;p. 250
  79. Lambert R. Treatment of esophagogastric tumors. Endoscopy. 2003;35:118–126
  80. Sorbi D, Fleischer DE. Nonsurgical approaches to esophageal malignancy. Curr Gastroenterol Rep. 2003;5:213–220
  81. Sarbia M, Stahl M, Fink U, et al.  Expression of apoptosis-regulating proteins and outcome of esophageal cancer patients treated by combined therapy modalities. Clin Cancer Res. 1998;4:2991–2997
  82. Kishi K, Doki Y, Miyata H, et al.  Prediction of the response to chemoradiation and prognosis in oesophageal squamous cancer. Br J Surg. 2002;89:597–603
  83. Safran H, DiPetrillo T, Nadeem A, et al.  Neoadjuvant Herceptin, paclitaxel, cisplatin, and radiation for adenocarcinoma of esophagus (A phase I study). Proc Am Soc Clin Oncol. 2002;21:141a; (abstr 560)
  84. Weber WA, Ott K, Becker K, et al.  Prediction of response to preoperative chemotherapy in adenocarcinomas of the esophagogastric junction by metabolic imaging. J Clin Oncol. 2001;19:3058–3065
  85. Downey RJ, Akhurst T, Ilson D, et al.  Whole body 18FDG-PET and the response of esophageal cancer to induction therapy (Results of a prospective trial). J Clin Oncol. 2003;21:428–432
  86. Schlag PM. Randomized trial of preoperative chemotherapy for squamous cell cancer of the esophagus. The Chirurgische Arbeitsgemeinschaft Fuer Onkologie der Deutschen Gesellschaft Fuer Chirurgie Study Group. Arch Surg. 1992;127:1446–1450
  87. Brenner B, Ilson DH, Minsky BD, et al.  A phase I trial of combined modality therapy for localized esophageal cancer (Escalating doses of continuous infusion paclitaxel with cisplatin and concurrent radiation therapy). J Clin Oncol. 2004;22:45–52
  88. Urba S, Orringer M, Iannettoni M, et al.  A phase II trial of preoperative cisplatin, paclitaxel, and radiation therapy (XRT) before trans-hiatal esophagectomy (THE) in patients (Pts) with locoregional esophageal cancer (CA). Proc Am Soc Clin Oncol. 2000;19:248a; (abstr)
  89. Heath EI, Burtness BA, Heitmiller RF, et al.  Phase II evaluation of preoperative chemoradiation and postoperative adjuvant chemotherapy for squamous cell and adenocarcinoma of the esophagus. J Clin Oncol. 2000;18:868–876

PII: S0093-7754(04)00236-2

doi: 10.1053/j.seminoncol.2004.04.015

Seminars in Oncology
Volume 31, Issue 4 , Pages 554-565 , August 2004

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