Seminars in Oncology
Volume 31, Issue 5 , Pages 653-658 , October 2004

Current controversies in the radiotherapeutic management of adult low-grade glioma

  • Edward G. Shaw

      Affiliations

    • Department of Radiation Oncology, Wake Forest University School of Medicine, Winston-Salem, NC.
    • Corresponding Author InformationAddress reprint requests to Edward G. Shaw, MD, Department of Radiation Oncology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1030.
    • ,
  • Stephen B. Tatter

      Affiliations

    • Department of Neurosurgery, Wake Forest University School of Medicine, Winston-Salem, NC.
    • ,
  • Glenn J. Lesser

      Affiliations

    • Department of Internal Medicine Section on Hematology and Oncology, Wake Forest University School of Medicine, Winston-Salem, NC.
    • ,
  • Thomas L. Ellis

      Affiliations

    • Department of Neurosurgery, Wake Forest University School of Medicine, Winston-Salem, NC.
    • ,
  • Constance A. Stanton

      Affiliations

    • Department of Pathology, Wake Forest University School of Medicine, Winston-Salem, NC.
    • ,
  • Volker W. Stieber

      Affiliations

    • Department of Radiation Oncology, Wake Forest University School of Medicine, Winston-Salem, NC.

References 

  1. Shaw EG , Daumas-Duport C , Scheithauer BW , et al.   Radiation therapy in the management of low-grade supratentorial astrocytomas . J Neurosurg . 1989;70:853–861
  2. Leighton C , Fisher B , Bauman G , et al.   Supratentorial low-grade glioma in adults (An analysis of prognostic factors and timing of radiation) . J Clin Oncol . 1997;15:1295–1301
  3. Glioma Meta-analysis Trialists (GMT) Group . Chemotherapy in adult high-grade glioma (A systematic review and meta-analysis of individual patient data from 12 randomized trials) . Lancet . 2002;359:1011–1018
  4. Karim AB , Afra D , Cornu P . Randomized trial on the efficacy of radiotherapy for cerebral low-grade glioma in the adult: European Organization for Research and Treatment of Cancer study 22845 with the Medical Research Council study BR04: An interim analysis . Int J Radiat Oncol Biol Phys . 2002;52:316–324
  5. Karim AB , Maat B , Hatlevoll R , et al.   A randomized trial on dose-response in radiation therapy of low-grade cerebral glioma (European Organization for Research and Treatment of Cancer (EORTC) study 22844) . Int J Radiat Oncol Biol Phys . 1996;36:549–556
  6. Kiebert GM , Curran D , Aaronson NK , et al.   Quality of life after radiation therapy of cerebral low-grade gliomas of the adult (Results of a randomized phase III trial on dose-response (EORTC trial 22844)) . Eur J Cancer . 1998;34:1902–1909
  7. Shaw E , Arusell R , Scheithauer B , et al.   Prospective randomized trial of low- versus high-dose radiation therapy in adults with supratentorial low-grade glioma (Initial report of a North Cancer Central Treatment Group/Radiation Therapy Oncology Group/Eastern Cooperative Oncology Group study) . J Clin Oncol . 2002;20:2267–2276
  8. Brown PD , Buckner JC , O’Fallon JR , et al.   Effects of radiotherapy on cognitive function in patients with low-grade glioma measured by the Folstein Mini-Mental State Examination . J Clin Oncol . 2003;21:2519–2524
  9. Eyre HJ , Crowley JJ , Townsend JJ , et al.   A randomized trial of radiotherapy versus radiotherapy plus CCNU for incompletely resected low-grade gliomas (A Southwest Oncology Group study) . J Neurosurg . 1993;78:909–914
  10. Berger MS , Deliganis AV , Dobbins J , et al.   The effect of extent of resection on recurrence in patients with low-grade cerebral hemisphere gliomas . Cancer . 1994;74:1784–1791
  11. Cairncross G , Macdonald D , Ludwin S , et al.   Chemotherapy for anaplastic oligodendroglioma. National Institute of Canada Clinical Trials Group . J Clin Oncol . 1994;12:2013–2021
  12. Quinn JA , Reardon DA , Friedman AH , et al.   Phase II trial of temozolomide in patients with progressive low-grade glioma . J Clin Oncol . 2003;21:646–651
  13. Cairncross JG , Ueki K , Zlatescu MC , et al.   Specific genetic predictors of chemotherapeutic response and survival in patients with anaplastic oligodendrogliomas . J Natl Cancer Inst . 1998;90:1473–1479
  14. Buckner JC , Gesme D , O’Fallon JR , et al.   A phase II trial of procarbazine, lomustine, and vincristine as initial therapy for patients with low-grade oligodendroglioma or oligoastrocytoma (Efficacy and association with chromosomal abnormalities) . J Clin Oncol . 2003;21:251–255

PII: S0093-7754(04)00329-X

doi: 10.1053/j.seminoncol.2004.07.007

Seminars in Oncology
Volume 31, Issue 5 , Pages 653-658 , October 2004

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