Seminars in Oncology
Volume 31, Issue 5 , Pages 684-692 , October 2004

Treatment of primary central nervous system lymphoma

  • Lisa M. DeAngelis

      Affiliations

    • Department of Neurology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
    • Corresponding Author InformationAddress reprint requests to Lisa M. DeAngelis, MD, Department of Neurology, Memorial Sloan-Kettering Cancer Center, 1275 York Ave, New York, NY 10021.
    • ,
  • Adília Hormigo

References 

  1. Lukes RJ , Collins RD . Immunologic characterization of human malignant lymphomas . Cancer . 1974;34:1488–1503
  2. Jellinger K , Radaskiewictz T , Slowik F . Primary malignant lymphomas of the central nervous system in man . Acta Neuropathol . 1975;(suppl 6):95–9102
  3. Burnstein SD , Kernohan JW , Uihlein A . Neoplasms of the reticuloendothelial system of the brain . Cancer . 1963;16:289–305
  4. Henry JM , Heffner RR , Dillard SH , et al.   Primary malignant lymphomas of the central nervous system . Cancer . 1974;34:1293–1302
  5. DeAngelis LM , Yahalom J , Heinemann M-H , et al.   Primary CNS lymphoma (Combined treatment with chemotherapy and radiotherapy) . Neurology . 1990;40:80–86
  6. Kawakami Y , Tabuchi K , Ohnishi R , et al.   Primary central nervous system lymphoma . J Neurosurg . 1985;62:522–527
  7. DeAngelis LM , Yahalom J , Rosenblum M , et al.   Primary CNS lymphoma (Managing patients with spontaneous and AIDS-related disease) . Oncology . 1987;1:52–59
  8. Gametchu B . Glucocorticoid receptor-like antigen in lymphoma cell membranes (Correlation to cell lysis) . Science . 1987;236:456–461
  9. Weller M . Glucocorticoid treatment of primary CNS lymphoma . J Neurooncol . 1999;43:237–239
  10. Hochberg FH , Miller DC . Primary central nervous system lymphoma . J Neurosurg . 1988;68:835–853
  11. Pollack IF , Lunsford LD , Flickinger JC , et al.   Prognostic factors in the diagnosis and treatment of primary central nervous system lymphoma . Cancer . 1989;63:939–947
  12. Bataille B , Delwail V , Menet E , et al.   Primary intracerebral malignant lymphoma (Report of 248 cases) . J Neurosurg . 2000;92:261–266
  13. Vokes EE , Ultmann JE , Golomb HM , et al.   Long-term survival of patients with localized diffuse histiocytic lymphoma . J Clin Oncol . 1985;3:1309–1317
  14. Nelson DF , Martz KL , Bonner H , et al.   Non-Hodgkin’s lymphoma of the brain: Can high dose, large volume radiation therapy improve survival? Report on a prospective trial by the Radiation Therapy Oncology Group (RTOG): RTOG 8315 . Int J Radiat Oncol Biol Phys . 1992;23:9–17
  15. Corry J , Smith JG , Wirth A , et al.   Primary central nervous system lymphoma (Age and performance status are more important than treatment modality) . Int J Radiat Oncol Biol Phys . 1998;41:615–620
  16. Shibamoto Y , Hayabuchi N , Hiratsuka J-I , et al.   Is whole-brain irradiation necessary for primary central nervous system lymphoma? Patterns of recurrence after partial-brain irradiation . Cancer . 2003;97:128–133
  17. Lai R , Rosenblum MC , DeAngelis LM . Primary CNS lymphoma (A whole brain disease?) . Neurology . 2002;59:1557–1562
  18. Brada M , Dearnaley D , Horwich A , et al.   Management of primary cerebral lymphoma with initial chemotherapy (Preliminary results and comparison with patients treated with radiotherapy alone) . Int J Radiat Oncol Biol Phys . 1990;18:787–792
  19. Abrey LE , Yahalom J , DeAngelis LM . Treatment for primary CNS lymphoma (The next step) . J Clin Oncol . 2000;18:3144–3150
  20. Shibamato Y , Sasai K , Oya N , et al.   Systemic chemotherapy with vincristine, cyclophosphamide, doxorubicin and prednisolone following radiotherapy for primary central nervous system lymphoma (A phase II study) . J Neurooncol . 1999;42:162–167
  21. Lachance DH , Brizel DM , Gockerman JP , et al.   Cyclophosphamide, doxorubicin, vincristine, and prednisone for primary central nervous system lymphoma (Short duration response and multifocal intracerebral recurrence preceding radiotherapy) . Neurology . 1994;44:1721–1727
  22. Liang BC , Grant R , Junck L , et al.   Primary central nervous system lymphoma (Treatment with multi-agent systemic and intrathecal chemotherapy with radiation therapy) . Int J Oncol . 1993;3:1001–1004
  23. O’Neill BP , Wang CH , O’Fallon JR , et al.   Primary central nervous system non-Hodgkin’s lymphoma (PCNSL) (Survival advantages with combined initial therapy? A final report of the North Central Cancer Treatment Group (NCCTG) Study 86-72-52) . Int J Radiat Oncol Biol Phys . 1999;43:559–563
  24. Schultz C , Scott C , Sherman W , et al.   Preirradiation chemotherapy with cyclophosphamide, doxorubicin, vincristine, and dexamethasone for primary CNS lymphomas (Initial report of Radiation Therapy Oncology Group protocol 88–06) . J Clin Oncol . 1996;14:556–564
  25. Mead GM , Bleehen NM , Gregor A , et al.   A Medical Research Council randomized trial in patients with primary cerebral non-Hodgkin lymphoma (Cerebral radiotherapy with and without cyclophosphamide, doxorubicin, vincristine, and prednisone chemotherapy) . Cancer . 2000;89:1359–1370
  26. Ott RJ , Brada M , Flower MA , et al.   Measurements of blood-brain barrier permeability in patients undergoing radiotherapy and chemotherapy for primary cerebral lymphoma . Eur J Cancer . 1991;27:1356–1361
  27. Chamberlain MC , Levin VA . Primary central nervous system lymphoma (A role for adjuvant chemotherapy) . J Neurooncol . 1992;14:271–275
  28. DeAngelis LM , Yahalom J , Thaler HT , et al.   Combined modality therapy for primary CNS lymphoma . J Clin Oncol . 1992;10:635–643
  29. Abrey LE , DeAngelis LM , Yahalom J . Long-term survival in primary CNS lymphoma . J Clin Oncol . 1998;16:859–863
  30. Glass J , Gruber ML , Cher L , et al.   Preirradiation methotrexate chemotherapy of primary central nervous system lymphoma (Long-term outcome) . J Neurosurg . 1994;81:188–195
  31. DeAngelis LM , Seiferheld W , Schold SC , et al.   Combination chemotherapy and radiotherapy for primary central nervous system lymphoma (Radiation Therapy Oncology Group study 93–10) . J Clin Oncol . 2002;20:4643–4648
  32. Reni M , Ferreri AJM , Garancini MP , et al.   Therapeutic management of primary central nervous system lymphoma in immunocompetent patients (Results of a critical review of the literature) . Ann Oncol . 1997;8:227–334
  33. Blay J-Y , Conroy T , Chevreau C , et al.   High-dose methotrexate for the treatment of primary cerebral lymphomas (Analysis and late neurologic toxicity in a retrospective series) . J Clin Oncol . 1998;16:864–871
  34. Cohen IJ , Vogel R , Matz S , et al.   Successful non-neurotoxic therapy (without radiation) of a multifocal primary brain lymphoma with a methotrexate, vincristine, and BCNU protocol (DEMOB) . Cancer . 1986;57:6–11
  35. Freilich RJ , Delattre J-Y , Monjour A , et al.   Chemotherapy without radiation therapy as initial treatment for primary CNS lymphoma in older patients . Neurology . 1996;46:435–439
  36. Lawler BE , Betensky R , Hochberg F , et al.   Primary central nervous system lymphoma (The Massachusetts General Hospital) . Proc Am Soc Clin Oncol . 2002;21:75; (abstr)
  37. Batchelor T , Carson K , O’Neill A , et al.   Treatment of primary CNS lymphoma with methotrexate and deferred radiotherapy (A report of NABTT 96–07) . J Clin Oncol . 2003;21:1044–1049
  38. Herrlinger U , Schabet M , Brugger W , et al.   German Cancer Society Neuro-Oncology Working Group NOA-03 multicenter trial of single-agent high-dose methotrexate for primary central nervous system lymphoma . Ann Neurol . 2002;51:247–252
  39. Sandor V , Stark-Vancs V , Pearson D , et al.   Phase II trial of chemotherapy alone for primary CNS and intraocular lymphoma . J Clin Oncol . 1998;16:3000–3006
  40. Cheng AL , Yeh KH , Uen WC , et al.   Systemic chemotherapy alone for patients with non-acquired immunodeficiency syndrome-related central nervous system lymphoma . Cancer . 1998;82:1946–1951
  41. Hoang-Xuan K , Taillander L , Chinot O , et al.   Chemotherapy alone as initial treatment for primary CNS lymphoma in patients older than 60 years (A multicenter phase II study (26952) of the European Organization for Research and Treatment of Cancer Brain Tumor Group) . J Clin Oncol . 2003;21:2726–2731
  42. McAllister LD , Doolittle ND , Guastadisegni PE , et al.   Cognitive outcomes and long-term follow-up results after enhanced chemotherapy delivery for primary central nervous system lymphoma . Neurosurgery . 2000;46:51–61
  43. Doolittle ND , Miner ME , Siegal T , et al.   Safety and efficacy of a multicenter study using intraarterial chemotherapy in conjunction with osmotic opening of the blood-brain barrier for the treatment of patients with malignant brain tumors . Cancer . 2000;88:637–647
  44. Kraemer DF , Fortin D , Doolittle ND , et al.   Association of total dose intensity of chemotherapy in primary central nervous system lymphoma (human non-acquired immunodeficiency syndrome) and survival . Neurosurgery . 2001;48:1033–1041
  45. Hiraga S , Arita N , Ohnishsi T , et al.   Rapid infusion of high-dose methotrexate resulting in enhanced penetration into cerebrospinal fluid and intensified tumor response in primary central nervous system lymphoma . J Neurosurg . 1999;91:221–230
  46. Abrey LE , Moskowitz CH , Mason WP , et al.   A phase II study of intensive methotrexate and cytarabine followed by high dose beam chemotherapy with autologous stem cell transplantation in patients with newly diagnosed primary central nervous system lymphoma . Proc Am Soc Clin Oncol . 2001;20:53; (abstr)
  47. Soussain C , Suzan F , Hoang-Xuan K , et al.   Results of intensive chemotherapy followed by hematopoietic stem-cell rescue in 22 patients with refractory or recurrent primary CNS lymphoma or intraocular lymphoma . J Clin Oncol . 2001;19:742–749
  48. Cheng T , Forsyth P , Chaudhry A , et al.   High-dose thiotepa, busulfan, cyclophosphamide and ASCT without whole-brain radiotherapy for poor prognosis primary CNS lymphoma . Bone Marrow Transplant . 2003;31:679–685
  49. Bendadi M , Longo DL . Biologic therapy for lymphoma . Curr Opin Oncol . 1999;11:343–350
  50. Raizer JJ , DeAngelis LM , Zelenetz AD , et al.   Activity of Rituximab in primary central nervous system lymphoma . Proc Am Soc Clin Oncol . 2000;19:166; (abstr)
  51. Herrlinger U , Brugger W , Bamberg M , et al.   PCV salvage chemotherapy for recurrent primary CNS lymphoma . Neurology . 2000;54:1707–1708
  52. Buggage RR , Chan CC , Nussenblatt RB . Ocular manifestations of central nervous system lymphoma . Cur Opin Oncol . 2001;13:137–142
  53. Hormigo A , DeAngelis LM . Ocular lymphoma (Clinical features, diagnosis, and treatment) . Clin Lymphoma . 2003;4:22–29
  54. Smet MD , Stark-Vancs V , Kohler DR , et al.   Intraocular levels of methotrexate after intravenous administration . Am J Ophthalmol . 1996;121:442–444
  55. Batchelor TT , Kolak G , Ciorda R , et al.   High-dose methotrexate for intraocular lymphoma . Clin Cancer Res . 2003;9:711–715
  56. Baumann MA , Ritch PS , Hande KR , et al.   Treatment of intraocular lymphoma with high-dose Ara-C . Cancer . 1986;57:1273–1275
  57. Strauchen JA , Dalton J , Friedman AH . Chemotherapy in the management of intraocular lymphoma . Cancer . 1989;63:1918–1921
  58. Soussain C , Merle-Béral H , Reux I , et al.   A single-center study of 11 patients with intraocular lymphoma treated with conventional chemotherapy followed by high-dose chemotherapy and autologous bone marrow transplantation in 5 cases . Leuk Lymphoma . 1996;23:339–345
  59. Fishburne BC , Wilson DJ , Rosenbaum JT , et al.   Intravitreal methotrexate as an adjunctive treatment of intraocular lymphoma . Arch Ophthalmol . 1997;115:1152–1156
  60. Smet MD , Vancs VS , Kohler D , et al.   Intravitreal chemotherapy for the treatment of recurrent intraocular lymphoma . Br J Ophthalmol . 1999;83:448–451
  61. Merchut MP , Haberland C , Naheedy MH , et al.   Long survival of primary cerebral lymphoma with progressive radiation necrosis . Neurology . 1985;35:552–556
  62. DeAngelis LM , Delattre J-Y , Posner JB . Radiation-induced dementia in patients cured of brain metastases . Neurology . 1989;39:789–796
  63. Bleyer WA . Neurologic sequelae of methotrexate and ionizing radiation (A new classification) . Cancer Treat Rep . 1981;65:89–98 (suppl)
  64. Geyer JR , Taylor EM , Milstein JM , et al.   Radiation, methotrexate, and white matter necrosis (laboratory evidence for neural radioprotection with preirradiation methotrexate) . Int J Oncol, Biol Phys . 1988;15:373–375
  65. Thiessen B , DeAngelis LM . Hydrocephalus in radiation leukoencephalopathy (Results of ventriculoperitoneal shunting) . Arch Neurol . 1998;55:705–710

PII: S0093-7754(04)00333-1

doi: 10.1053/j.seminoncol.2004.07.011

Seminars in Oncology
Volume 31, Issue 5 , Pages 684-692 , October 2004

Article Tools

* Image Usage & Resolution