Seminars in Oncology
Volume 31, Issue 5 , Pages 693-701 , October 2004

Management of brain metastases

  • Kristin A. Bradley

      Affiliations

    • Department of Human Oncology, University of Wisconsin, Madison, WI, USA.
  • ,
  • Minesh P. Mehta

      Affiliations

    • Department of Human Oncology, University of Wisconsin, Madison, WI, USA.
    • M.M. has received research funding or has served on the advisory board of or has participated in lectureship programs sponsored by one or more of the following: Schering-Plough, Pharmacyclics, Eli Lilly, GlaxoSmithKline, General Electric, TomoTherapy, Inc., Varian, ProCertus BioPharm, Inc. UltraVisual, Gammex RMI, Peregrine, AstraZeneca, Bristol-Myers Squibb, and ADAC.
    • Corresponding Author InformationAddress reprint requests to Minesh P. Mehta, MD, University of Wisconsin, Department of Human Oncology, 600 Highland Ave, K4/310-3684, Madison, WI 53792.

References 

  1. Wen PY , Black PM , Loeffler JS . Metastatic brain cancer . In:  DeVita VT ,  Hellman S ,  Rosenberg SA editor. Cancer (Principles and Practice of Oncology, vol 2) . ed 6. Philadelphia, PA: Lippincott Williams & Wilkins; 2001;p. 2655–2670
  2. Cappuzzo F , Mazzoni F , Maestri A , et al.   Medical treatment of brain metastases from solid tumours . Forum (Genova) . 2000;10:137–148
  3. Mehta MP , Tremont-Lukats I . Radiosurgery for single and multiple metastases . In:  Sawaya R editors. Intracranial Metastases (Current Management Strategies) . Malden, MA: Blackwell; 2004;p. 139–164
  4. Greenberg H , Chandler WF , Sandler HM . Brain metastases . In:  Greenberg H ,  Chandler WF ,  Sandler HM editor. Brain Tumors, vol 54 . New York, NY: Oxford University Press; 1999;p. 299–317
  5. Kelly K , Bunn PAJ . Is it time to reevaluated our approach to the treatment of brain metastases in patients with non-small cell lung cancer? . Lung Cancer . 1998;20:85–91
  6. Ellis R , Gregor A . The treatment of brain metastases from lung cancer . Lung Cancer . 1998;20:81–84
  7. Postmus PE , Haaxma-Reiche H , Smit EF , et al.   Treatment of brain metastases of small-cell lung cancer (Comparing teniposide and teniposide with whole-brain radiotherapy—A phase III study of the European Organization for the Research and Treatment of Cancer Lung Cancer Cooperative Group) . J Clin Oncol . 2000;18:3400–3408
  8. Delattre JY , Krol G , Thaler HT , et al.   Distribution of brain metastases . Arch Neurol . 1988;45:741–744
  9. Zimm S , Wampler GL , Stablein D , et al.   Intracerebral metastases in solid tumor patients. Natural history and results of treatment . Cancer . 1981;48:384–394
  10. Nussbaum ES , Djalilian HR , Cho KH , et al.   Brain metastases (Histology, multiplicity, surgery, and survival) . Cancer . 1996;78:1781–1788
  11. Sundstrom JT , Minn H , Lertola KK , et al.   Prognosis of patients treated for intracranial metastases with whole-brain irradiation . Ann Med . 1998;30:296–299
  12. Batchelor T , DeAngelis LM . Medical management of cerebral metastases . Neurosurg Clin North Am . 1996;7:435–446
  13. Horton J , Baxter DH , Olson KB , et al.   The management of metastases to the brain by irradiation and corticosteroids . Am J Roentgenol Radiat Ther Nucl Med . 1971;3:334–336
  14. Cohen N , Strauss G , Lew R , et al.   Should prophylactic anticonvulsants be administered to patients with newly-diagnosed cerebral metastases? A retrospective analysis . J Clin Oncol . 1988;6:1621–1624
  15. Coia LR , Aaronson N , Linggood R , et al.   A report of the consensus workshop panel on the treatment of brain metastases . Int J Radiat Oncol Biol Phys . 1992;23:223–227
  16. Lentzsch S , Reichardt P , Weber F , et al.   Brain metastases in breast cancer (Prognostic factors and management) . Eur J Cancer . 1999;35:580–585
  17. Gaspar LE , Scott C , Rotman M , et al.   Recursive partitioning analysis (RPA) of prognostic factors in three Radiation Therapy Oncology Group (RTOG) brain metastases trials . Int J Radiat Oncol Biol Phys . 1997;37:745–751
  18. Borgelt B , Gelber R , Kramer S , et al.   The palliation of brain metastases (Final results of the first two studies by the Radiation Therapy Oncology Group) . Int J Radiat Oncol Biol Phys . 1980;6:1–9
  19. Murray KJ , Scott C , Greenberg HM , et al.   A randomized phase III study of accelerated hyperfractionation versus standard in patients with unresected brain metastases (A report of the Radiation Therapy Oncology Group (RTOG) 9104) . Int J Radiat Oncol Biol Phys . 1997;39:571–574
  20. Agboola O , Benoit B , Cross P , et al.   Prognostic factors derived from recursive partition analysis (RPA) of Radiation Therapy Oncology Group (RTOG) brain metastases trials applied to surgically resected and irradiated brain metastatic cases . Int J Radiat Oncol Biol Phys . 1998;42:155–159
  21. Gaspar LE , Scott C , Murray K , et al.   Validation of the RTOG recursive partitioning analysis (RPA) classification for brain metastases . Int J Radiat Oncol Biol Phys . 2000;47:1001–1006
  22. Patchell RA , Tibbs PA , Walsh JW , et al.   A randomized trial of surgery in the treatment of single metastases to the brain . N Engl J Med . 1990;322:494–500
  23. Noordijk EM , Vecht CJ , Haaxma-Reiche H , et al.   The choice of treatment of single brain metastasis should be based on extracranial tumor activity and age . Int J Radiat Oncol Biol Phys . 1994;29:711–717
  24. Vecht CJ , Haaxma-Reiche H , Noordijk EM , et al.   Treatment of single brain metastasis (Radiotherapy alone or combined with neurosurgery?) . Ann Neurol . 1993;33:583–590
  25. Mintz AH , Kestle J , Rathbone MP , et al.   A randomized trial to assess the efficacy of surgery in addition to radiotherapy in patients with a single cerebral metastasis . Cancer . 1996;78:1470–1476
  26. Patchell RA , Tibbs PA , Regine WF , et al.   Postoperative radiotherapy in the treatment of single metastases to the brain (A randomized trial) . JAMA . 1998;280:1485–1489
  27. Bindal RK , Sawaya R , Leavens ME , et al.   Surgical treatment of multiple brain metastases . J Neurosurg . 1993;79:210–216
  28. Young RF . Radiosurgery for the treatment of brain metastases . Semin Surg Oncol . 1998;14:70–78
  29. Loeffler JS , Barker FG , Chapman PH . Role of radiosurgery in the management of central nervous system metastases . Cancer Chemother Pharmacol . 1999;43(suppl):S11–S14
  30. Auchter RM , Lamond JP , Alexander E , et al.   A multiinstitutional outcome and prognostic factor analysis of radiosurgery for resectable single brain metastasis . Int J Radiat Oncol Biol Phys . 1996;35:27–35
  31. Breneman JC , Warnick RE , Albright REJ , et al.   Stereotactic radiosurgery for the treatment of brain metastases. Results of a single institution series . Cancer . 1997;79:551–557
  32. Seung SK , Sneed PK , McDermott MW , et al.   Gamma knife radiosurgery for malignant melanoma brain metastases . Cancer J Sci Am . 1998;4:103–109
  33. Alexander E , Loeffler JS . The case for radiosurgery . Clin Neurosurg . 1999;45:32–40
  34. Sanghavi SN , Miranpuri SS , Chappell R , et al.   Radiosurgery for patients with brain metastases (A multi-institutional analysis, stratified by the RTOG recursive partitioning analysis method) . Int J Radiat Oncol Biol Phys . 2001;51:426–434
  35. Kondziolka D , Patel A , Lunsford LD , et al.   Stereotactic radiosurgery plus whole brain radiotherapy versus radiotherapy alone for patients with multiple brain metastases . Int J Radiat Oncol Biol Phys . 1999;45:427–434
  36. Chougule PB , Burton-Williams M , Saris S , et al.   Randomized treatment of brain metastasis with gamma knife radiosurgery, whole brain radiotherapy or both . Int J Radiat Oncol Biol Phys . 2000;48:114; (abstr)
  37. Sperduto PW , Scott C , Andrews D , et al.   Preliminary report of RTOG 9508 (A phase III trial comparing whole brain irradiation alone versus whole brain irradiation plus stereotactic radiosurgery for patients with two or three unresected brain metastases) . Int J Radiat Oncol Biol Phys . 2000;48:113; (abstr)
  38. Sperduto PW , Scott C , Andrews D , et al.   Stereotactic radiosurgery with whole brain radiation therapy improves survival in patients with brain metastases (Report of Radiation Therapy Oncology Group phase III study 95–08) . Int J Radiat Oncol Biol Phys . 2002;54:3; (abstr)
  39. Rock J , Haines S , Recht L , et al.   Practice parameters for the management of single brain metastases . Neurosurg Focus . 2000;9:1–9
  40. Shu HKG , Sneed PK , Shiau CY , et al.   Factors influencing survival after gamma knife radiosurgery for patients with single and multiple brain metastases . Cancer J Sci Am . 1996;2:335–342
  41. Sperduto PW , Hall WA . The cost-effectiveness for alternative treatments for single brain metastases . In:  Kondziolka D editors. Radiosurgery . Basel, Switzerland: Karger; 1996;p. 180–187
  42. Rutigliano MJ , Lundsford LD , Kondziolka D . The cost-effectiveness of stereotactic radiosurgery versus surgical resection in the treatment of solitary metastatic brain tumors . Neurosurg . 1995;37:445–455
  43. Mehta M , Noyes W , Craig B , et al.   A cost-effectiveness and cost-utility analysis of radiosurgery vs. resection for single-brain metastases . Int J Radiat Oncol Biol Phys . 1997;39:445–454
  44. Mintz A , Cairncross JG . Treatment of a single brain metastasis. The role of radiation following surgical resection . JAMA . 1998;280:1527–1529
  45. Sneed PK , Lamborn KR , Torstner JM , et al.   Radiosurgery for brain metastases (Is whole brain radiotherapy necessary?) . Int J Radiat Oncol Biol Phys . 1999;3:549–558
  46. Sneed PK , Suh JH , Goetsch SJ , et al.   A multi-institutional review of radiosurgery alone vs. radiosurgery with whole brain radiotherapy as the initial management of brain metastases . Int J Radiat Oncol Biol Phys . 2002;53:519–526
  47. Regine WF , Huhn JL , Patchell RA , et al.   Risk of symptomatic brain tumor recurrence and neurologic deficit after radiosurgery alone in patients with newly diagnosed brain metastases (Results and implications) . Int J Radiat Oncol Biol Phys . 2002;52:333–338
  48. Komarnicky LT , Phillips TL , Martz K , et al.   A randomized phase III protocol for the evaluation of misonidazole combined with radiation in the treatment of patients with brain metastases (RTOG-7916) . Int J Radiat Oncol Biol Phys . 1991;20:53–58
  49. Phillips TL , Scott CB , Leibel SA , et al.   Results of a randomized comparison of radiotherapy and bromodeoxyuridine with radiotherapy alone for brain metastases (Report of RTOG trial 89–05) . Int J Radiat Oncol Biol Phys . 1995;33:339–348
  50. Carde P , Timmerman R , Mehta MP , et al.   Multicenter phase Ib/II trial of the radiation enhancer motexafin gadolinium in patients with brain metastases . J Clin Oncol . 2001;19:2074–2083
  51. Mehta MP , Shapiro WR , Glantz MJ , et al.   Lead-in phase to randomized trial of motexafin gadolinium and whole-brain radiation for patients with brain metastases (Centralized assessment of magnetic resonance imaging, neurocognitive, and neurologic end points) . J Clin Oncol . 2002;20:2445–3453
  52. Mehta MP , Rodrigus P , Terhaard CHJ , et al.   Survival and neurologic outcomes in a randomized trial of motexafin gadolinium and whole-brain radiation therapy in brain metastases . J Clin Oncol . 2003;21:2529–2536
  53. Fenner MH , Possinger K . Chemotherapy for breast cancer brain metastases . Onkologie . 2002;25:474–479
  54. Lesser GJ . Chemotherapy of cerebral metastases from solid tumors . Neurosurg Clin North Am . 1996;7:527–536
  55. Postmus PE , Smit EF . Chemotherapy for brain metastases of lung cancer (A review) . Ann Oncol . 1999;10:753–759
  56. Franciosi V , Cocconi G , Michiara M , et al.   Front-line chemotherapy with cisplatin and etoposide for patients with brain metastases from breast carcinoma, nonsmall cell lung carcinoma, or malignant melanoma (A prospective study) . Cancer . 1999;85:1599–1605
  57. Yung WK , Prados MD , Yay-Tur R , et al.   Multicenter phase II trial of temozolomide in patients with anaplastic astrocytoma or anaplastic oligoastrocytoma at first relapse . J Clin Oncol . 1999;17:2762–2771
  58. Christodoulou C , Bafaloukos D , Kosmidis P , et al.   Phase II study of temozolomide in heavily pretreated cancer patients with brain metastases . Ann Oncol . 2001;12:249–254
  59. Abrey LE , Olson JD , Raizer JJ , et al.   A phase II trial of temozolomide for patients with recurrent or progressive brain metastases . J Neurooncol . 2001;53:259–265
  60. Friedman HS , Evans B , Reardon D , et al.   Phase II trial of temozolomide for patients with progressive brain metastases . Proc Am Soc Clin Oncol . 2003;22:102; (abstr)
  61. Siena S , Landonio G , Baietta E , et al.   Multicenter phase II study of temozolomide therapy for brain metastasis in patients with malignant melanoma, breast cancer, and non-small cell lung cancer . Proc Am Soc Clin Oncol . 2003;22:102; (abstr)
  62. Bafaloukos D , Gogas H , Georgoulias V , et al.   Temozolomide in combination with docetaxel in patients with advanced melanoma (A phase II study of the Hellenic Cooperative Oncology Group) . J Clin Oncol . 2002;20:420–425
  63. Martinez-Cedillo J , Alvarado A , Lara FU , et al.   Temozolomide (TMZ) in metastatic breast cancer (BC) to central nervous system (CNS) . Proc Am Soc Clin Oncol . 2003;22:88; (abstr)
  64. Antonadou D , Paraskevaidis M , Sarris G , et al.   Phase II randomized trial of temozolomide and concurrent radiotherapy in patients with brain metastases . J Clin Oncol . 2002;20:3644–3650
  65. Dardoufas C , Miliadou A , Skarleas C , et al.   Concomitant temozolomide (TMZ) and radiotherapy (RT) followed by adjuvant treatment with temozolomide in patients with brain metastases from solid tumours . Proc Am Soc Clin Oncol . 2001;20:75b; (abstr)
  66. Verger E , Gil M , Yaya R , et al.   Concomitant temozolomide (TMZ) and radiotherapy (RT) in patients with brain metastases (Randomized multicenteric phase II study, a preliminary report) . Proc Am Soc Clin Oncol . 2002;21:78a; (abstr)
  67. Antonadou D , Coliarakis N , Paraskevaidis M , et al.   Whole brain radiotherapy alone or in combination with temozolomide for brain metastases. A phase III study . Int J Radiat Oncol Biol Phys . 2002;54:93–94 (abstr)
  68. Verger E , Gil M , Yaya R , et al.   Concomitant temozolomide (TMZ) and whole brain radiotherapy (WBRT) in patients with brain metastases (BM) (Randomized multicentric phase II study) . Proc Am Soc Clin Oncol . 2003;22:101; (abstr)
  69. Agarwala SS , Kirkwood JM . Temozolomide, a novel alkylating agent with activity in the central nervous system, may improve the treatment of advanced metastatic melanoma . Oncologist . 2000;5:144–151
  70. Stupp R , Ostermann S , Leyvraz S , et al.   Cerebrospinal fluid levels of temozolomide as a surrogate marker for brain penetration . Proc Am Soc Clin Oncol . 2001;20:59; (abstr)
  71. Abrey LE , Mehta MP . Treatment of brain metastases (A short review of current therapies and the emerging role of temozolomide) . Clin Adv Hematol Oncol . 2003;1:231–236

PII: S0093-7754(04)00334-3

doi: 10.1053/j.seminoncol.2004.07.012

Seminars in Oncology
Volume 31, Issue 5 , Pages 693-701 , October 2004