Seminars in Oncology
Volume 31, Issue 6 , Pages 822-826 , December 2004

Concomitant radiochemotherapy or accelerated radiotherapy: Analysis of two randomized trials of the French Head and Neck Cancer Group (GORTEC)

  • J. Bourhis

      Affiliations

    • Institut Gustave Roussy, Radiation Oncology and Statistic Departments, Villejuif, France
    • Corresponding Author InformationAddress reprint requests to Professor J. Bourhis, Department of Radiation-Oncology, Gustave Roussy Institute, 39 rue Camille Desmoulins, 94805 Villejuif, France
    • ,
  • G. Calais

      Affiliations

    • Clinique d’Oncologie et de Radiothérapie, CHU Tours, Tours France
    • ,
  • M. Lapeyre

      Affiliations

    • Centre Vautrin, Nancy, France
    • ,
  • J. Tortochaux

      Affiliations

    • Centre Perrin, Clermont-Ferrand, France
    • ,
  • M. Alfonsi

      Affiliations

    • Clinique Sainte Catherine, Avignon, France
    • ,
  • C. Sire

      Affiliations

    • Centre Hospitalier, Lorient, France
    • ,
  • E. Bardet

      Affiliations

    • Centre Gauducheau, Nantes, France
    • ,
  • M. Rives

      Affiliations

    • Centre Val D’aurelle, Montpellier, France
    • ,
  • P. Bergerot

      Affiliations

    • Centre Regaud, Toulouse, France
    • ,
  • B. Rhein

      Affiliations

    • Centre Dolet, Saint-Nazaire,France
    • ,
  • B. Desprez

      Affiliations

    • Centre de Radiothérapie Vannes, France
    • ,
  • GORTEC

References 

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  2. Parker SL , Tong T , Bolden S , et al.   Cancer statistics, 1996 . Cancer J Clin . 1996;65:5–27
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  7. Jackson SM , Weir LM , Hay JH , et al.   A randomized trial of accelerated versus conventional radiotherapy in head and neck cancer . Radiother Oncol . 1997;43:39–46
  8. Bourhis J , Pignon JP . Meta-analyses in head and neck squamous cell carcinoma (What is the role of chemotherapy?) . Clin North Am . 1999;13:769–775
  9. Pignon JP , Bourhis J , Domenge C , et al.  MACH-NC collaborative group   Meta-analysis of chemotherapy in head and neck squamous cell carcinoma . Lancet . 2000;355:949–955
  10. Bourhis J , Wibault P , Lusinchi A , et al.   Status of accelerated fractionated radiotherapy in head and neck squamous cell carcinoma . Curr Opin Oncol . 1997;9:262–266
  11. Datta NR , Dutta Choudhry A , Gupta S , et al.   Twice a day versus once a day radiation therapy in head and neck cancer . Int J Radiat Oncol Biol Phys . 1989;17(suppl 1):132; (abstr)
  12. Fu K , Cooper J , Marcial V , et al.   Evolution of the Radiation Therapy Oncology Group clinical trials for head and neck cancer . Int J Radiat Oncol Biol Phys . 1996;35:425–438
  13. Horiot JC , LeFur R , N’Guyen T , et al.   Hyperfractionation versus conventional fractionation in oropharyngeal carcinoma (Final analysis of a randomized trial of the EORTC cooperative group of radiotherapy) . Radiother Oncol . 1992;25:231–241
  14. Horiot JC , Bontemps P , van den Bogaert W , et al.   Accelerated fractionation compared to conventional fractionation improves locoregional control in the radiotherapy of advanced head and neck cancer (Results of the EORTC 22851 randomized trial) . Radiother Oncol . 1997;44:39–46
  15. Jeremic B , Shibamoto Y , Stanisavljevic B , et al.   Radiation therapy alone or with concurrent low-dose daily either cisplatin or carboplatin in locally advanced unresectable squamous cell carcinoma of the head and neck (A prospective randomized trial) . Radiother Oncol . 1997;43:29–37
  16. Keane TJ , Cummings BJ , O Sullivan B , et al.   Results of a randomized trial of hyperfractionated versus conventional radiation therapy administered over 4 weeks for squamous carcinoma of the larynx and pharynx . Proceedings of the 4th International Conference on Head and Neck Cancer, Toronto, Canada . 1996; July, p 131
  17. Maciejewski B , Skladowsk K , Pilecki B , et al.   Randomized clinical trial on accelerated 7 days per week fractionation in radiotherapy for head and neck cancer. Preliminary report on acute toxicity . Radiother Oncol . 1996;40:137–145
  18. Olmi P , Fallai C , Rossi F , et al.   Conventional radiotherapy versus accelerated hyperfractionated radiotherapy versus conventional radiotherapy and concomitant chemotherapy in advanced oropharyngeal carcinoma (A randomized clinical trial) . Proceedings of the 4th International Conference on Head and Neck Cancer, Toronto, Canada . 1996; July, p 213
  19. Overgaard J , Hansen HS , Specht L , et al.   Five compared with six fractions per week of conventional radiotherapy of squamous-cell carcinoma of head and neck (DAHANCA 6 and 7 randomised controlled trial) . Lancet . 2003;362:933–940
  20. Pinto LHJ , Canary PCV , Araujo CMM , et al.   Prospective randomized trial comparing hyperfractionated versus conventional radiotherapy in stage III and IV oropharyngeal carcinoma . Int J Radiat Oncol Biol Phys . 1991;21:557–562
  21. Poulsen MG , Denham JW , Peters LJ , et al.   A randomised trial of accelerated and conventional radiotherapy for stage III and IV squamous carcinoma of the head and neck (A Trans-Tasman Radiation Oncology Group Study) . Radiother Oncol . 2001;60: 113–112
  22. Saunders M , Dische S , Barrett A , et al.   Randomized multicentre trial of CHART vs conventional radiotherapy in head and neck and non small cell lung cancer (An interim report) . Br J Cancer . 1996;73:1455–1462
  23. Bourhis J , Fortin A , Dupuis O , et al.   Very accelerated radiotherapy (Preliminary results in locally unresectable head and neck squamous cell carcinoma) . Int J Radiat Oncol Biol Phys . 1995;32:747–752
  24. Bourhis J , Wibault P , Eschwege F . Very accelerated fractionation . Int J Radiat Oncol Biol Phys . 1996;32:889–890
  25. Bourhis J, Lapeyre M, Tortochaux J, Rives M, et al: Very accelerated compared to conventional radiotherapy in HNSCC: Results of a GORTEC phase III randomized trial. J Clin Oncol (in press)
  26. Denis F , Garaud P , Bardet E , et al.   Late toxicity results of the GORTEC 94-01 randomized trial comparing radiation therapy with concomitant radio-chemotherapy for advanced-stage oropharynx carcinoma. Comparison of LENT/SOMA, RTOG/EORTC and NCI/CTC scoring systems . Int J Radiat Oncol Biol Phys . 2003;55:93–98
  27. Bourhis J , Syz N , Overgaard J , et al.   Conventional vs modified fractionated radiotherapy. Meta-analysis of radiotherapy in head and neck carcinoma: A meta-analysis based on individual patient data . Int J Radiat Oncol Biol Phys . 2002;54(suppl):71–72

PII: S0093-7754(04)00399-9

doi: 10.1053/j.seminoncol.2004.09.002

Seminars in Oncology
Volume 31, Issue 6 , Pages 822-826 , December 2004

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