Seminars in Oncology
Volume 31, Issue 6 , Pages 786-793 , December 2004

Concurrent chemoradiotherapy for head and neck cancer

  • Bruce Brockstein

      Affiliations

    • Department of Medicine, Northwestern University, Feinberg School of Medicine, Evanston Northwestern Healthcare, Evanston, IL.
    • Corresponding Author InformationAddress reprint requests to Bruce Brockstein, MD, Assistant Professor of Medicine, Northwestern University, Feinberg School of Medicine, Evanston Northwestern Healthcare, 2650 Ridge Ave, Evanston, IL 60201.
    • ,
  • Everett E. Vokes

      Affiliations

    • Department of Medicine and Radiation Oncology, and Section of Hematology-Oncology, University of Chicago, Chicago, IL.

References 

  1. Head and Neck Contracts Program: Adjuvant chemotherapy for advanced head and neck squamous carcinoma. Final report of the Head and Neck Contracts Program . Cancer . 1987;60:301–311
  2. Schuller DE , Metch B , Stein DW , et al.   Preoperative chemotherapy in advanced resectable head and neck cancer (Final report of the Southwest Oncology Group) . Laryngoscope . 1988;98:1205–1211
  3. Laramore GB , Scott CB , Al-Sarraf M , et al.   Adjuvant chemotherapy for resectable squamous cell carcinomas of the head and neck (Report on Intergroup study 0034) . Int J Radiat Oncol Biol Phys . 1992;23:705–713
  4. Paccagnella A , Orlando A , Marchiori C , et al.   Phase III trial of initial chemotherapy in stage III or IV head and neck cancers (A study by the Gruppo di Studio Sui Tumori della Testa e del Collo) . J Natl Cancer Inst . 1994;86:265–272
  5. Bernier J , Domenge C , Eschwege F , et al.   Chemo-radiotherapy as compared to radiotherapy alone significantly increases disease-free and overall survival in head and neck cancer patients after surgery (Results of EORTC phase III trial 22931) . Int J Radiat Oncol Biol Phys . 2001;51(suppl 1):1; (abstr)
  6. Cooper JS , Pajak TF , Forastiere AA , et al.   Postoperative concurrent chemoradiotherapy in high risk SCCA of the head and neck (Initial report of RTOG 9501/intergroup phase III trial) . Proc Am Soc Clin Oncol . 2002;21:903; (abstr)
  7. Weichselbaum RR , Beckett MA , Schwartz JL , et al.   Radioresistant tumor cells are present in head and neck carcinomas that recur after radiotherapy . Int J Radiat Oncol Biol Phys . 1998;15:575–581
  8. Elkind MM , Sutton H . X-ray damage and recovery in mammalian cells in culture . Nature . 1959;184:705–718
  9. Bush RS , Jenkin RDT , Alh WEC , et al.   Definitive evidence for hypoxic cells influencing cure in cancer therapy . Br J Cancer . 1978;37(suppl 3):302–307
  10. Beard CJ , Coleman CN . Current therapeutic strategies toward hypoxic tumor cells . Principle Pract Oncol Updates . 1991;5:1–9
  11. Withers HR . Biologic basis of radiation therapy . In:  Perez CA ,  Brady LW editor. Principle and Practices of Radiation Oncology . (ed 2). Philadelphia, PA: Lippincott; 1992;p. 64–84
  12. Henke M , Laszig R , Rube C , Schafer U , et al.   Erythropoietin to treat head and neck cancer patients with anaemia undergoing radiotherapy (Randomised, double-blind, placebo-controlled trial) . Lancet . 2003;362:1255–1260
  13. Green FL , Page DL , Fleming ID , et al.   In: Head and neck sites, in AJCC Cancer Staging Handbook . (ed 6). New York, NY: Springer-Verlag; 2003;p. 27–98
  14. El-Sayed S , Nelson N . Adjuvant and adjunctive chemotherapy in the management of squamous cell carcinoma of the head and neck region (A meta-analysis of prospective and randomized trials) . J Clin Oncol . 1996;14:838–847
  15. Munro A . An overview of randomized controlled trials of adjuvant chemotherapy in head and neck cancer . Br J Cancer . 1995;71:83–91
  16. Pignon JP , Bourhis J , Domenge C , et al.   Chemotherapy added to locoregional treatment for head and neck squamous cell carcinoma (Three meta-analyses of updated individual patient data) . Lancet . 2000;355:949–955
  17. Brockstein B . Integration of taxanes into primary chemotherapy for squamous cell carcinoma of the head and neck (Promise fulfilled?) . Curr Opin Oncol . 2000;12:221–228
  18. Calais G , Alfonsi M , Bardet E , et al.   Randomized trial of radiation versus concomitant chemotherapy and radiation for advanced-stage oropharynx carcinoma . J Natl Cancer Inst . 1999;15:2081–2086
  19. Brizel DM , Albers ME , Fisher R , et al.   Hyperfractionated irradiation with or without concurrent chemotherapy for locally advanced head and neck cancer . N Engl J Med . 1998;338:1798–1804
  20. Wendt TG , Grabenbauer GG , Rodel CM . Simultaneous radiotherapy versus radiotherapy alone in advanced head and neck cancer (A randomized multicenter study) . J Clin Oncol . 1998;16:1318–1324
  21. Jeremic B , Shibamoto Y , Milicic B , et al.   Hyperfractionated radiation therapy with or without concurrent low dose cisplatin in locally advanced squamous cell carcinoma of the head and neck (A prospective randomized trial) . J Clin Oncol . 2000;18:1458–1464
  22. Haffty BG , Son YH , Papac R , et al.   Chemotherapy as an adjunct to radiation in the treatment of squamous cell carcinoma of the head and neck (Results of the Yale Mitomycin Randomized Trials) . J Clin Oncol . 1997;15:268–276
  23. Bachaud JM , Cohen-Jonathan E , Alzieu C , et al.   Combined postoperative radiotherapy and weekly cisplatin infusion for locally advanced head and neck carcinoma (Final report of a randomized trial) . Int J Radiat Oncol Biol Phys . 1996;36:999–1004
  24. Adelstein DJ , Lavertu P , Saxton J , et al.   Mature results of a phase III randomized trial comparing concurrent chemoradiotherapy with radiation therapy alone in patients with stage III and IV squamous cell carcinoma of the head and neck . Cancer . 2000;88:876–883
  25. Forastiere AA , Goepfert H , Maor M , et al.   Concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal cancer . N Engl J Med . 2003;349:2091–2098
  26. Domenge C , Hill C , Lefebvre JL , et al.   Randomized trial of neoadjuvant chemotherapy in oropharyngeal carcinoma . Br J Cancer . 2000;83:1594–1598
  27. Posner MR , Lefebvre JL . Docetaxel induction therapy in locally advanced squamous cell carcinoma of the head and neck . Br J Cancer . 2003;88:11–17
  28. Haddad R , Colevas AD , Tishler R , et al.   Docetaxel, cisplatin, and 5-fluorouracil-based induction chemotherapy in patients with locally advanced squamous cell carcinoma of the head and neck . Cancer . 2003;97:412–418
  29. Vokes EE , Stenson K , Rosen F , et al.   Weekly carboplatin and paclitaxel followed by concomitant paclitaxel, fluorouracil, and hydroxyurea chemoradiotherapy; curative and organ-preserving therapy for advanced head and neck cancer . J Clin Oncol . 2003;21:320–326
  30. Vokes EE , Kies MS , Haraf DJ , et al.   Induction chemotherapy followed by concomitant chemoradiotherapy for advanced head and neck cancer (Impact on the natural history of the disease) . J Clin Oncol . 1995;13:876–883
  31. Kies MS , Haraf DJ , Athanasiadis I , et al.   Induction chemotherapy followed by concurrent chemoradiation for advanced head and neck cancer (Improved disease control and survival) . J Clin Oncol . 1998;16:2715–2721
  32. Brockstein B , Haraf DJ , Kies MS , et al.   Pattern of failure, prognostic factors and survival in locoregionally advanced head and neck cancer treated with concomitant chemoradiotherapy (A 9-year, 337 patient multi-institutional experience) . Ann Oncol . 2004;15:1179–1186
  33. Vokes EE , Kies M , Haraf DJ , et al.   Concomitant chemoradiotherapy as primary therapy for locoregionally advanced head and neck cancer . J Clin Oncol . 2000;18:1652–1661
  34. Kies MS , Haraf DJ , Rosen F , et al.   Concomitant infusional paclitaxel and fluorouracil, oral hydroxyurea, and hyperfractionated radiation for locally advanced squamous head and neck cancer . J Clin Oncol . 2001;19:1961–1969
  35. Rosen FR , Haraf DJ , Kies MS , et al.   Multicenter randomized phase II study of paclitaxel (1-hour infusion), fluorouracil, hydroxyurea and concomitant twice-daily radiation with or without erythropoietin for advanced head and neck cancer . Clin Cancer Res . 2003;9:1689–1697
  36. Haraf DJ , Stenson K , Argiris A , et al.   Weekly carboplatin and paclitaxel followed by concomitant TFHX with reduced dose XRT for advanced head and neck cancer . Proc Am Soc Clin Oncol . 2003;22:2009; (abstr)
  37. Tishler R , Norris CM , Colevas AD , et al.   A phase I/II trial of concurrent docetaxel and radiation after induction chemotherapy in patients with poor prognosis squamous cell carcinoma of the head and neck . Cancer . 2002;95:1472–1481
  38. Machtay M , Rosenthal DI , Hershock D , et al.   Organ preservation therapy using induction plus concurrent chemoradiation for advanced resectable oropharyngeal carcinoma (A University of Pennsylvania phase II trial) . J Clin Oncol . 2002;20:3964–3971
  39. Garden AS , Pajak TF , Vokes E , et al.   Preliminary results of RTOG 9703—A phase II randomized trial of concurrent radiation and chemotherapy for advanced squamous cell carcinoma of the head and neck . Proc Am Soc Clin Oncol . 2001;20:891; (abstr)
  40. Adelstein DJ , Adams GL , Wagner H , et al.   An intergroup phase III comparison of standard radiation and two schedules of concurrent chemoradiotherapy in patients with unresectable squamous cell head and neck cancer . J Clin Oncol . 2003;21:92–98

PII: S0093-7754(04)00403-8

doi: 10.1053/j.seminoncol.2004.09.006

Seminars in Oncology
Volume 31, Issue 6 , Pages 786-793 , December 2004

Article Tools

* Image Usage & Resolution