Seminars in Oncology
Volume 31, Issue 6 , Pages 726-733 , December 2004

Descriptive epidemiology and risk factors for head and neck cancer

  • Erich M. Sturgis

      Affiliations

    • Department of Head and Neck Surgery, The University of Texas M.D. Anderson Cancer Center, Houston, TX
    • Department of Epidemiology, The University of Texas M.D. Anderson Cancer Center, Houston, TX
    • Corresponding Author InformationAddress reprint requests to Erich M. Sturgis, MD, Department of Head and Neck Surgery, 1515 Holcombe Blvd, Unit 441, Houston, TX 77030-4009
    • ,
  • Qingyi Wei

      Affiliations

    • Department of Epidemiology, The University of Texas M.D. Anderson Cancer Center, Houston, TX
    • ,
  • Margaret R. Spitz

      Affiliations

    • Department of Epidemiology, The University of Texas M.D. Anderson Cancer Center, Houston, TX

References 

  1. Jemal A , Tiwari RC , Murray T , et al.   Cancer statistics, 2004 . CA Cancer J Clin . 2004;54:8–29
  2. Parkin DM , Pisani P , Ferlay J . Estimates of the worldwide incidence of 25 major cancers in 1990 . Int J Cancer . 1999;80:827–841
  3. Funk GF , Karnell LH , Robinson RA , et al.   Presentation, treatment, and outcome of oral cavity cancer (A national cancer database report) . Head Neck . 2002;24:165–180
  4. Blot WJ , McLaughlin JK , Winn DM , et al.   Smoking and drinking in relation to oral and pharyngeal cancer . Cancer Res . 1988;48:3282–3287
  5. Franceschi S , Talamini R , Barra S , et al.   Smoking and drinking in relation to cancers of the oral cavity, pharynx, larynx, and esophagus in Northern Italy . Cancer Res . 1990;50:6502–6507
  6. Franceschi S , Levi F , La Vecchia C , et al.   Comparison of the effect of smoking and alcohol drinking between oral and pharyngeal cancer . Int J Cancer . 1999;83:1–4
  7. Merletti F , Boffetta P , Ciccone G , et al.   Role of tobacco and alcoholic beverages in the etiology of cancer of the oral cavity/oropharynx in Torino, Italy . Cancer Res . 1989;49:4919–4924
  8. Silverberg E . Cancer statistics, 1985 . CA Ca J Clin . 1985;35:19–35
  9. Boring CC , Squires TS , Tong T . Cancer statistics, 1993 . CA Ca J Clin . 1993;43:7–26
  10. SEER Cancer Statistics Review 1973–1999, 2003. Web site: http://seer.cancer.gov/
  11. Shemen LJ , Klotz J , Schottenfeld D , et al.   Increase of tongue cancer in young men . JAMA . 1984;252:1857
  12. Depue RH . Rising mortality from cancer of the tongue in young white males . N Engl J Med . 1986;315:647
  13. Schantz SP , Byers RM , Goepfert H . Tobacco and cancer of the tongue in young adults . JAMA . 1988;259:1943–1944
  14. Myers JN , Elkins T , Roberts D , et al.   Squamous cell carcinoma of the tongue in young adults (Increasing incidence and factors that predict treatment outcomes) . Otolaryngol Head Neck Surg . 2000;122:44–51
  15. Schantz SP , Yu GP . Head and neck cancer incidence trends in young Americans, 1973–1997, with a special analysis for tongue cancer . Arch Otolaryngol Head Neck Surg . 2002;128:268–274
  16. Parkin DM , Bray F , Ferlay J , et al.   Estimating the world cancer burden (Globocan 2000) . Int J Cancer . 2001;94:153–156
  17. Ghafoor A , Jemal A , Cokkinides V , et al.   Cancer statistics for African Americans . Ca Cancer J Clin . 2002;52:326–341
  18. Wynder EL , Bross IJ , Feldman RM . A study of the etiological factors in cancer of the mouth . Cancer . 1957;10:1300–1323
  19. Hammond EC , Horn D . Smoking and death rates—Report on forty-four months of follow-up of 187,783 men . JAMA . 1958;166:1294–1308
  20. Smoking and Health. Report of the Advisory Committee to the Surgeon General of the Public Health Service . Washington, DC: US Department of Health, Education, and Welfare; 1964;
  21. Doll R , Hill AB . Lung cancer and other causes of death in relation to smoking; a second report on the mortality of British doctors . Br Med J . 1956;2:1071–1081
  22. Falk RT , Pickle LW , Brown LM , et al.   Effect of smoking and alcohol consumption on laryngeal cancer risk in coastal Texas . Cancer Res . 1989;49:4024–4029
  23. Schlecht NF , Franco EL , Pintos J , et al.   Interaction between tobacco and alcohol consumption and the risk of cancers of the upper aero-digestive tract in Brazil . Am J Epidemiol . 1999;150:1129–1137
  24. LaVecchia C , Tavani A , Franceschi S , et al.   Epidemiology and prevention of oral cancer . Oral Oncol . 1997;33:302–312
  25. Cattaruzza MS , Maisonneuve P , Boyle P . Epidemiology of laryngeal cancer . Oral Oncol, Eur J Cancer . 1996;32B:293–305
  26. Schlecht NF , Franco EL , Pintos J , et al.   Effect of smoking cessation and tobacco type on the risk of cancers of the upper aero-digestive tract in Brazil . Epidemiology . 1999;10:412–418
  27. Zhu K , Levine RS , Brann EA , et al.   Case-control study evaluating the homogeneity and heterogeneity of risk factors between sinonasal and nasopharyngeal cancers . Int J Cancer . 2002;99:119–123
  28. Iribarren C , Tekawa IS , Sidney S , et al.   Effect of cigar smoking on the risk of cardiovascular disease, chronic obstructive pulmonary disease, and cancer in men . N Engl J Med . 1999;340:1773–1780
  29. Baker F , Ainsworth SR , Dye JT , et al.   Health risks associated with cigar smoking . JAMA . 2000;284:735–740
  30. Moore C , Catlin D . Anatomic origins and locations of oral cancer . Am J Surg . 1967;114:510–513
  31. Scully C , Bedi R . Ethnicity and oral cancer . Lancet . 2000;1:37–42
  32. Winn DM . Smokeless tobacco and cancer (The epidemiologic evidence) . CA Cancer J Clin . 1988;38:236–243
  33. Rao DN , Ganesh B , Rao RS , et al.   Risk assessment of tobacco, alcohol and diet in oral cancer—A case-control study . Int J Cancer . 1994;58:469–473
  34. Idris AM , Ahmed HM , Malik MOA . Toombak dipping and cancer of the oral cavity in the Sudan (A case-control study) . Int J Cancer . 1995;63:477–480
  35. Idris AM , Ibrahim SO , Vasstrand EN , et al.   The Swedish snus and the Sudanese toombak (Are they different?) . Oral Oncol . 1998;34:558–566
  36. Lewin F , Norell SE , Johansson H , et al.   Smoking tobacco, oral snuff, and alcohol in the etiology of squamous cell carcinoma of the head and neck (A population-based case-referent study in Sweden) . Cancer . 1998;82:1367–1375
  37. Schildt EB , Eriksson M , Hardell L , et al.   Oral snuff, smoking habits and alcohol consumption in relation to oral cancer in a Swedish case-control study . Int J Cancer . 1998;77:341–346
  38. CDC . Tobacco use—United States, 1900–1999 . MMWR . 1999;48:986–993
  39. CDC . Cigarette smoking among adults—United States, 1999 . MMWR . 2001;50:869–873
  40. Marwick C . Increasing use of chewing tobacco, especially among younger persons, alarms Surgeon General . JAMA . 1993;269:195
  41. Merchant A , Husain SSM , Hosain M , et al.   Paan without tobacco (An independent risk factor for oral cancer) . Int J Cancer . 2000;86:128–131
  42. Day GL , Blot WJ , Austin DF , et al.   Racial differences in risk of oral and pharyngeal cancer (Alcohol, tobacco, and other determinants) . J Natl Cancer Inst . 1993;85:465–473
  43. Kabat GC , Wynder EL . Type of alcoholic beverage and oral cancer . Int J Cancer . 1989;43:190–194
  44. Lee JJ , Hong WK , Hittelman WN , et al.   Predicting cancer development in oral leukoplakia (Ten years of translation research) . Clin Cancer Res . 2000;6:1702–1710
  45. Papadimitrakopoulou VA . Chemoprevention of head and neck cancer (An update) . Curr Opin Oncol . 2002;14:318–322
  46. Day GL , Blot WJ , Shore RE , et al.   Second cancers following oral and pharyngeal cancers (Role of tobacco and alcohol) . J Natl Cancer Inst . 1994;86:131–137
  47. Sturgis EM , Miller RH . Second primary malignancy in the head and neck cancer patient . Ann Otol Rhinol Laryngol . 1995;104:946–954
  48. Dictor M , Johnson A . Association of inverted sinonasal papilloma with non-sinonasal head-and-neck carcinoma . Int J Cancer . 2000;85:811–814
  49. Maden C , Beckmann AM , Thomas DB , et al.   Human papillomaviruses, herpes simplex viruses, and the risk of oral cancer in men . Am J Epidemiol . 1992;135:1093–1102
  50. Aygenc E , Selcuk A , Celikkanat S , et al.   The role of Helicobacter pylori infection in the cause of squamous cell carcinoma of the larynx . Otolaryngol Head Neck Surg . 2001;25:520–521
  51. Grandis JR , Perez-Perez GI , Yu VL , et al.   Lack of serologic evidence for Helicobacter pylori infection in head and neck cancer . Head Neck . 1997;19:216–218
  52. ZurHausen H . Papillomaviruses causing cancer (Evasion for host-cell control in early events in carcinogenesis) . J Natl Cancer Inst . 2000;92:690–698
  53. McKaig RG , Baric RS , Olshan AF . Human papillomavirus and head and neck cancer (Epidemiology and molecular biology) . Head Neck . 1998;20:250–265
  54. Mineta H , Ogino T , Amano HM , et al.   Human papillomavirus (HPV) type 16 and 18 detected in head and neck squamous cell carcinoma . Anticancer Res . 1998;18:4765–4768
  55. Steinberg BM , DiLorenzo TP . A possible role for human papillomaviruses in head and neck cancer . Cancer Metast Rev . 1996;15:91–112
  56. Snijders P , Cromme FV , van den Brule A , et al.   Prevalence and expression of human papillomavirus in tonsillar carcinomas, indicating a possible viral etiology . Int J Cancer . 1992;51:845–850
  57. Capone RB , Pai SI , Koch WM , et al.   Detection and quantitation of human papillomavirus (HPV) DNA in the sera of patients with HPV-associated head and neck squamous cell carcinoma . Clin Cancer Res . 2000;6:4171–4175
  58. Gillison ML , Koch WM , Capone RB , et al.   Evidence for a causal association between human papillomavirus and a subset of head and neck cancers . J Natl Cancer Inst . 2000;92:709–720
  59. Gillison ML , Shah KV . Human papillomavirus-associated head and neck squamous cell carcinoma (Mounting evidence for an etiologic role for human papillomavirus in a subset of head and neck cancers) . Curr Opin Oncol . 2001;13:183–188
  60. Hengstermann A , Linares LK , Ciechanover A , et al.   Complete switch from Mdm2 to human papillomavirus E6-mediated degradation of p53 in cervical cancer cells . Proc Natl Acad Sci U S A . 2001;98:1218–1223
  61. Andl T , Kahn T , Pfuhl A , et al.   Etiological involvement of oncogenic human papillomavirus in tonsillar squamous cell carcinomas lacking retinoblastoma cell cycle control . Cancer Res . 1998;58:5–13
  62. Munger K , Werness BA , Dyson N , et al.   Complex formation of human papillomavirus E7 proteins with the retinoblastoma tumor suppressor gene product . EMBO J . 1989;8:4099–4105
  63. Fouret P , Monceaux G , Temam S , et al.   Human papillomavirus in head and neck squamous cell carcinomas in nonsmokers . Arch Otolaryngol HNS . 1997;123:513–516
  64. Smith EM , Hoffman HT , Summersgill KS , et al.   Human papillomavirus and risk of oral cancer . Laryngoscope . 1998;108:1098–1103
  65. Smith EM , Summersgill KF , Allen J , et al.   Human papillomavirus and risk of laryngeal cancer . Ann Otol Rhinol Laryngol . 2000;109:1069–1076
  66. Strome SE , Savva A , Brissett AE , et al.   Squamous cell carcinoma of the tonsils (A molecular analysis of HPV associations) . Clin Cancer Res . 2002;8:1093–1100
  67. Mork J , Lie AK , Glattre E , et al.   Human papilloma virus infection as a risk factor for squamous-cell carcinoma of the head and neck . N Engl J Med . 2001;344:1125–1131
  68. Schwartz SM , Daling JR , Doody DR , et al.   Oral cancer risk in relation to sexual history and evidence of human papillomavirus infection . J Natl Cancer Inst . 1998;90:1626–1636
  69. Dahlstrom KR , Adler-Storthz K , Etzel CJ , et al.   Human papillomavirus type 16 infection and squamous cell carcinoma of the head and neck in never smokers (A matched pair analysis) . Clin Cancer Res . 2003;9:2620–2626
  70. Henle W , Henle G , Ho HC , et al.   Antibodies to Epstein-Barr virus in nasopharyngeal carcinoma, other head and neck neoplasms, and control groups . J Natl Cancer Inst . 1970;44:225–231
  71. Pearson GR , Weiland LH , Neel HB , et al.   Application of Epstein-Barr virus (EBV) serology to the diagnosis of North American nasopharyngeal carcinoma . Cancer . 1983;51:260–268
  72. Feinmesser R , Miyazaki I , Cheung R , et al.   Diagnosis of nasopharyngeal carcinoma by DNA amplification of tissue obtained by fine-needle aspiration . N Engl J Med . 1992;326:17–21
  73. Yong-Sheng Z , Sham JST , Ng MH , et al.   Immunoglobulin A against viral capsid antigen of Epstein-Barr virus and indirect mirror examination of the nasopharynx in the detection of asymptomatic nasopharyngeal carcinoma . Cancer . 1992;69:3–7
  74. Chien YC , Chen JY , Liu MY , et al.   Serologic markers of Epstein-Barr virus infection and nasopharyngeal carcinoma in Taiwanese men . N Engl J Med . 2001;345:1877–1882
  75. Raab-Traub N , Flynn K , Pearson G , et al.   The differentiated form of nasopharyngeal carcinoma contains Epstein-Barr virus DNA . Int J Cancer . 1987;39:25–29
  76. Lin SY , Tsang NM , Kao SC , et al.   Presence of Epstein-Barr virus latent membrane protein 1 gene in the nasopharyngeal swabs from patients with nasopharyngeal carcinoma . Head Neck . 2001;23:194–200
  77. Sheen TS , Ko JY , Chang YL , et al.   Nasopharyngeal swab and PCR for the screening of nasopharyngeal carcinoma in the endemic area (A good supplement to the serologic screening) . Head Neck . 1998;20:732–738
  78. Walter MA , Menarguez-Palanca J , Peiper SC . Epstein-Barr virus detection in neck metastases by polymerase chain reaction . Laryngoscope . 1992;102:481–485
  79. Lin JC , Chen KY , Wang WY , et al.   Detection of Epstein-Barr virus DNA in the peripheral blood cells of patients with nasopharyngeal carcinoma (Relationship to distant metastasis and survival) . J Clin Oncol . 2001;19:2607–2615
  80. Lo YMD , Chan LYS , Lo KW , et al.   Quantitative analysis of cell-free Epstein-Barr virus DNA in plasma of patients with nasopharyngeal carcinoma . Cancer Res . 1999;59:1188–1191
  81. Loff B , Cordner S . Passive smoking test case wins in Australia . Lancet . 2001;357:1511
  82. Chapman S . Australian bar worker wins payout in passive smoking case . Br Med J . 2001;322:1139
  83. Zhang ZF , Morgenstern H , Spitz MR , et al.   Environmental tobacco smoking, mutagen sensitivity, and head and neck squamous cell carcinoma . Cancer Epidemiol Biomark Prev . 2000;9:1043–1049
  84. Tan E-H , Adelstein DJ , Droughton MLT , et al.   Squamous cell head and neck cancer in nonsmokers . Am J Clin Oncol . 1997;20:146–150
  85. Morrison MD . Is chronic gastroesophageal reflux a causative factor in glottic carcinoma? . Otolaryngol Head Neck Surg . 1988;99:370–373
  86. Ward PH , Hanson DG . Reflux as an etiological factor of carcinoma of the laryngopharynx . Laryngoscope . 1988;98:1195–1199
  87. Koufman JA . The otolaryngologic manifestations of gastroesophageal reflux disease (GERD) (A clinical investigation of 225 patients using ambulatory 24-hour pH monitoring and an experimental investigation of the role of acid and pepsin in the development of laryngeal injury) . Laryngoscope . 1991;101:1–78
  88. Biacabe B , Gleich LL , Laccourreye O , et al.   Silent gastroesophageal reflux disease in patients with pharyngolaryngeal cancer (further results) . Head Neck . 1998;20:510–514
  89. Copper MP , Smit CF , Stanojcic LD , et al.   High incidence of laryngopharyngeal reflux in patients with head and neck cancer . Laryngoscope . 2000;110:1007–1011
  90. El-Serag HB , Hepworth EJ , Lee P , et al.   Gastroesophageal reflux disease is a risk factor for laryngeal and pharyngeal cancer . Am J Gastroenterol . 2001;96:2013–2018
  91. Donald PJ . Marijuana smoking—Possible cause of head and neck carcinoma in young patients . Otolaryngol Head Neck Surg . 1986;94:517–521
  92. Caplan GA , Brigham BA . Marijuana smoking and carcinoma of the tongue; is there an association? . Cancer . 1990;66:1005–1006
  93. Zhang ZF , Morgenstern H , Spitz MR , et al.   Marijuana use and increased risk of squamous cell carcinoma of the head and neck . Cancer Epidemiol Biomark Prev . 1999;8:1071–1078
  94. Sidney S , Quesenberry CP , Friedman GD , et al.   Marijuana use and cancer incidence (California, U.S.A.) . Cancer Causes Control . 1997;8:722–728
  95. Winn DM , Ziegler RG , Pickle LW , et al.   Diet in the etiology of oral and pharyngeal cancer among women from the southern United States . Cancer Res . 1984;44:1216–1222
  96. McLaughlin JK , Gridley G , Block G , et al.   Dietary factors in oral and pharyngeal cancer . J Natl Cancer Inst . 1988;80:1237–1243
  97. Zheng W , Blot WJ , Shu XO , et al.   Diet and other risk factors for laryngeal cancer in Shanghai, China . Am J Epidemiol . 1992;136:178–191
  98. Levi F , Pasche C , LaVecchia C , et al.   Food groups and risk of oral and pharyngeal cancer . Int J Cancer . 1998;77:705–709
  99. Schantz SP , Zhang ZF , Spitz MS , et al.   Genetic susceptibility to head and neck cancer (interaction between nutrition and mutagen sensitivity) . Laryngoscope . 1997;107:765–781
  100. Ning JP , Yu MC , Wang QS , et al.   Consumption of salted fish and other risk factors for nasopharyngeal carcinoma (NPC) in Tianjiin, a low-risk region for NPC in the People’s Republic of China . J Natl Cancer Inst . 1990;82:291–296
  101. Farrow DC , Vaughan TL , Berwick M , et al.   Diet and nasopharyngeal cancer in a low-risk population . Int J Cancer . 1998;78:675–679
  102. Almadori G , Bussu F , Galli J , et al.   Serum folate and homocysteine levels in head and neck squamous cell carcinoma . Cancer . 2002;94:1006–1011
  103. Negri E , Franceschi S , Bosetti C , et al.   Selected micronutrients and oral and pharyngeal cancer . Int J Cancer . 2000;86:122–127
  104. Weinstein SJ , Gridley G , Harty LC , et al.   Folate intake, serum homocysteine and methylenetetrahydrofolate reductase (MTHFR) C677T genotype not associated with oral cancer risk in Puerto Rico . J Nutr . 2002;132:762–767
  105. Mannetje A , Kogevinas M , Luce D , et al.   Sinonasal cancer, occupation, and tobacco smoking in European women and men . Am J Ind Med . 1999;36:101–107
  106. Luce D , Gerin M , Morcet JF , et al.   Sinonasal cancer and occupational exposure to textile dust . Am J Ind Med . 1997;32:205–210
  107. Holt GR . Sinonasal neoplasms and inhaled air toxics . Otolaryngol Head Neck Surg . 1994;111:12–14
  108. Straif K , Keil U , Taeger D , et al.   Exposure to nitrosamines, carbon black, asbestos, and talc and mortality from stomach, lung, and laryngeal cancer in a cohort of rubber workers . Am J Epidemiol . 2000;152:297–306
  109. Browne K , Gee JB . Asbestos exposure and laryngeal cancer . Ann Occup Hyg . 2000;44:239–250
  110. Ko JY , Chen CL , Lui LT , et al.   Radiation-induced malignant fibrous histiocytoma in patients with nasopharyngeal carcinoma . Arch Otolaryngol Head Neck Surg . 1996;122:535–538
  111. Saku T , Hayashi Y , Takahara O , et al.   Salivary gland tumors among atomic bomb survivors, 1950–1987 . Cancer . 1997;79:1465–1475
  112. Preston-Martin S , Thomas DC , White SC , et al.   Prior exposure to medical and dental x-rays related to tumors of the parotid gland . J Natl Cancer Inst . 1988;80:943–949
  113. Goldgar DG , Easton DF , Cannon-Albright LA , et al.   Systematic population-based assessment of cancer risk in first-degree relatives of cancer probands . J Natl Cancer Inst . 1994;86:1600–1608
  114. Foulkes WD , Brunet JS , Kowalski LP , et al.   Family history of cancer is a risk factor for squamous cell carcinoma of the head and neck in Brazil (A case-control study) . Int J Cancer . 1995;63:769–773
  115. Copper MP , Jovanovic A , Nauta JJP , et al.   Role of genetic factors in the etiology of squamous cell carcinoma of the head and neck . Arch Otolaryngol Head Neck Surg . 1995;121:157–160
  116. Foulkes WD , Brunet JS , Sieh W , et al.   Familial risks of squamous cell carcinoma of the head and neck (Retrospective case-control study) . Br Med J . 1996;313:716–721
  117. Sturgis EM , Wei Q . Genetic susceptibility-molecular epidemiology of head and neck cancer . Curr Opin Oncol . 2002;14:310–317
  118. Cheng L , Eicher SA , Guo Z , et al.   Reduced DNA repair capacity in head and neck cancer patients . Cancer Epidemiol Biomarkers Prev . 1998;7:465–468
  119. Wang LE , Sturgis EM , Eicher SA , et al.   Mutagen sensitivity to benzo[a]pyrene diol epoxide and the risk of squamous cell carcinoma of the head and neck . Clin Cancer Res . 1998;4:1773–1778
  120. Wu X , Gu J , Hong WK , et al.   Benzo[a]pyrene diol epoxide and bleomycin sensitivity and susceptibility to cancer of upper aerodigestive tract . J Natl Cancer Inst . 1998;90:1393–1399
  121. Cloos J , Nieuwenhuis EJC , Boomsma DI , et al.   Inherited susceptibility to bleomycin-induced chromatid breaks in cultured peripheral blood lymphocytes . J Natl Cancer Inst . 1999;91:1125–1130

PII: S0093-7754(04)00410-5

doi: 10.1053/j.seminoncol.2004.09.013

Seminars in Oncology
Volume 31, Issue 6 , Pages 726-733 , December 2004

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