Seminars in Oncology
Volume 32, Issue 1 , Pages 85-94 , February 2005

Liver-directed therapies in colorectal cancer

  • Daniel T. Ruan

      Affiliations

    • Department of Surgery, University of California, San Francisco, San Francisco, CA
    • ,
  • Robert S. Warren

      Affiliations

    • Department of Surgery, University of California, San Francisco, San Francisco, CA
    • Corresponding Author InformationAddress reprint requests to Robert S. Warren, MD, 1600 Divisidero St, Room A-723, San Francisco, CA 94143-1932

References 

  1. American Cancer Society . In: Cancer Facts & Figures 2004 . Atlanta, GA: American Cancer Society; 2004;p. 4
  2. Taylor I , Mullee MA , Campbell MJ . Prognostic index for the development of liver metastases in patients with colorectal cancer . Br J Surg . 1999;77:499–501
  3. Weiss L , Grundman E , Torhorst J , et al.   Haematogenous metastatic patterns in colonic carcinoma (an analysis of 1541 necropsies) . J Pathol . 1986;150:195–203
  4. Rivera E , Fraschini G , Esparza-Guerra L , et al.   Frontline arterial infusion chemotherapy for hepatic metastases in breast cancer patients . Cancer Ther . 1999;2:44–49
  5. Steele G , Ravikumar TS . Resection of hepatic metastases from colorectal cancer. Biologic perspectives . Ann Surg . 1989;210:127–138
  6. Scheele J , Stangl R , Altendorf-Hofman A . Hepatic metastases from colorectal carcinoma (Impact of surgical rsection on the natural history) . Br J Surg . 1990;77:1241–1246
  7. Adson MA , van Heerden JA , Adson MH , et al.   Resection of hepatic metastases from colorectal cancer . Arch Surg . 1984;119:647–651
  8. Luna-Perez P , Rodriguez-Coria DF , Arroyo B , et al.   The natural history of liver metastases from colorectal cancer . Arch Med Res . 1998;29:319–324
  9. Nordlinger B , Guiguet M , Vaillant JC , et al.   Surgical resection of colorectal carcinoma metastases to the liver. A prognostic scoring system to improve case selection, based on 1568 patients . Cancer . 1996;77:1254–1262
  10. Fong Y , Fortner J , Sun RL , et al.   Clinical score for predicting recurrence after hepatic resection for metastatic colorectal carcinoma (An analysis of 1541 cases) . Ann Surg . 1999;230:309–318
  11. Glasgow RE , Showstack JA , Katz PP , et al.   The relationship between hospital volume and outcomes of hepatic resection for hepatocellular carcinoma . Arch Surg . 1999;134:30–35
  12. Iwatsuki S , Dvorchik I , Madariaga JR , et al.   Hepatic resection for metastatic colorectal adenocarcinoma (A proposal of a prognostic scoring system) . J Am Coll Surg . 1999;189:291–299
  13. Scheele J , Stang R , Altendorf-Hofman A , et al.   Resection of colorectal liver metastases . World J Surg . 1995;19:59–71
  14. Cady B , Jenkins RL , Steele GD , et al.   Surgical margin in hepatic resection for colorectal metastasis (A critical and improvable determinant of outcome) . Ann Surg . 1998;227:566–571
  15. Wanebo HJ , Chu QD , Vezeridis MP , et al.   Patient selection for hepatic resection of colorectal metastases . Arch Surg . 1996;131:322–329
  16. Scaife CL , Curley SA , Izzo F , et al.   Feasibility of adjuvant hepatic artery infusion of chemotherapy after radiofrequency ablation with or without resection in patients with hepatic metastases from colorectal cancer . Ann Surg Oncol . 2002;10:348–354
  17. Seki T , Wakabayashi M , Nakagawa T , et al.   Percutaneous microwave coagulation therapy for solitary metastatic liver tumors from colorectal cancer (A pilot clinical study) . Am J Gastroenterol . 1999;94:322–327
  18. Shibata T , Niinobu T , Ogata N , et al.   Microwave coagulation therapy for multiple hepatic metastases from colorectal carcinoma . Cancer . 2000;89:276–284
  19. Gelczer RK , Charboneau JW , Hussain S , et al.   Complications of percutaneous ethanol ablation . J Ultrasound Med . 1998;17:531–533
  20. Castells A , Bruix J , Bru C , et al.   Treatment of small hepatocellular carcinoma in cirrhotic patients (A cohort study comparing surgical resection and percutaneous ethanol injection) . Hepatology . 1993;18:1121–1126
  21. Breedis C , Young G . The blood supply of neoplasms in the liver . Am J Pathol . 1954;30:969–985
  22. Ensminger WD , Gyves JW . Clinical pharmacology of hepatic arterial chemotherapy . Semin Oncol . 1983;10:176–182
  23. Sullivan RD , Norcross JW , Watkins E . Chemotherapy of metastatic liver cancer by prolonged hepatic-artery infusion . N Engl J Med . 1964;270:321–327
  24. Lorenz M , Muller HH , Schramm H , et al.   Randomized trial of surgery versus surgery followed by adjuvant hepatic arterial infusion with 5-fluorouracil and folinic acid for liver metastases of colorectal cancer . Ann Surg . 1998;228:756–762
  25. Kemeny N, Huang Y, Cohen AM , et al.   Hepatic arterial infusion of chemotherapy after resection of hepatic metastases from colorectal cancer . N Engl J Med . 1999;341:2039–2048
  26. Kemeny MM, Adak S, Gray B , et al.   Combined-modality treatment for resectable metastatic colorectal carcinoma to the liver (Surgical resection of hepatic metastases in combination with continuous infusion of chemotherapy—An intergroup study) . J Clin Oncol . 2002;20:1499–1505
  27. Gonen M , Hummer A , Zeroudakis A , et al.   Thymidylate synthase expression in hepatic tumors is a predictor of survival and progression in patients with resectable metastatic colorectal cancer . J Clin Oncol . 2003;21:406–412
  28. Meta-analysis Group in Cancer . Reappraisal of hepatic arterial infusion in the treatment of nonresectable liver metastases from colorectal cancer . J Natl Cancer Inst . 1996;88:252–258
  29. Harmantas A , Rotstein LE , Langer B . Regional versus systemic therapy in the treatment of colorectal carcinoma metastatic to the liver. Is there a survival difference? Meta-analysis of the published literature . Cancer . 1996;78:1639–1645
  30. Lorenz M , Muller HH . Randomized, multicenter trial of fluorouracil plus leucovorin administered either via hepatic arterial or intravenous infusion versus fluorodeoxyuridine administered via hepatic arterial infusion in patients with nonresectable liver metastases from colorectal carcinoma . J Clin Oncol . 2000;18:243–254
  31. Kerr DJ , McArdle CS , Lederman J , et al.   Intrahepatic arterial versus intravenous fluorouracil and folinic acid for colorectal cancer liver metastases (A multicentre randomized trial) . Lancet . 2003;361:368–373
  32. Douillard JY , Sobrero A , Carnaghi C , et al.   Metastatic colorectal cancer (Integrating irinotecan into combination and sequential chemotherapy) . Ann Oncol . 2003;14(suppl 2):7–12
  33. Bossi G , Mazzaro G , Porrello A , et al.   Wild-type p53 gene transfer is not detrimental to normal cells in vivo (Implications for tumor gene therapy) . Oncogene . 2004;23:418–425
  34. Habib NA , Hodgson HJ , Lemoine N , et al.   A phase I/II study of hepatic artery infusion with wtp53-CMV-Ad in metastatic liver tumours . Hum Gene Ther . 1999;10:2019–2034
  35. Venook AP , Bergsland EK , Ring E , et al.   Gene therapy of colorectal liver metastases using recombinant adenovirus encoding wt p53 (SCH 58500) via hepatic artery infusion (A phase I study) . Proc Am Soc Clin Oncol . 1998;17:431c; (abstr)
  36. Schuler M , Herrman D , DeGreve JL , et al.   Adenovirus-mediated wild-type p53 gene transfer in patients receiving chemotherapy for advanced non-small cell lung cancer (Results of a multicenter phase II trial) . J Clin Oncol . 2001;19:1750–1758
  37. Kuball J , Wen SF , Leissner J , et al.   Successful adenovirus-mediated wild-type p53 gene transfer in patients with bladder cancer by intravesical vector instillation . J Clin Oncol . 2002;20:957–965
  38. Pagliaro LC , Keyhani A , Williams D , et al.   Repeated intravesical instillations of an adenoviral vector in patients with locally advanced bladder cancer (A phase I study of p53 gene therapy) . J Clin Oncol . 2003;21:2247–2253
  39. Buller RE , Runnebaum IB , Karlan BY , et al.   A phase I/II trial of rAd/p53 (SCH 58500) gene replacement in recurrent ovarian cancer . Cancer Gene Ther . 2002;9:553–566
  40. Freeman SM , Abboud CN , Whartenby KA , et al.   The “bystander effect” (Tumor regression when a fraction of the tumor mass is genetically modified) . Cancer Res . 1993;53:5274–5283
  41. Hirschowitz EA , Ohwada A , Pascal WR , et al.   Hum Gene Ther . 1995;8:1055–1063
  42. Kievit E , Bershad E , Ng E , et al.   Superiority of yeast over bacterial cytosine deaminase for enzyme/prodrug gene therapy in colon cancer xenografts . Cancer Res . 1999;59:1417–1421
  43. Zhang M , Li S , Nyati MK , et al.   Regional delivery and selective expression of a high-activity yeast cytosine deaminase in an intrahepatic colon cancer model . Cancer Res . 2003;63:658–663
  44. Ueda K , Iwahashi M , Nakamori M , et al.   Improvement of carcinoembryonic antigen-specific prodrug gene therapy for experimental colon cancer . Surgery . 2003;133:309–317
  45. Crystal RG , Hirschowitz E , Lieberman M . Phase I study of direct administration of a replication deficient adenovirus vector containing the E. coli cytosine deaminase gene to metastatic colon carcinoma of the liver in association with the oral administration of the pro-drug 5-fluorocytosine . Hum Gen Ther . 1997;8:985–1001
  46. Link CJ , Levy JP , McCann LZ , et al.   Gene therapy for colon cancer with the herpes simplex thymidine kinase gene . J Surg Oncol . 1997;64:289–294
  47. Sung MW , Yeh H-C , Thung SN , et al.   Intratumoral adenovirus-mediated suicide gene transfer for hepatic metastases from colorectal adenocarcinoma (Results of a phase I clinical trial) . Mol Ther . 2001;4:182–191
  48. Habib NA , Sarraf CE , Mitry RR , et al.   E1B-deleted adenovirus (dl1520) gene therapy for patients with primary and secondary liver tumors . Hum Gen Ther . 2001;12:219–226
  49. Heise C , Sampson-Johannes A , Williams A , et al.   ONYX-015, and E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents . Nat Med . 1997;3:639–645
  50. Yoon SS , Nakamura H , Carroll NM , et al.   An oncolytic herpes simplex virus type 1 selectively destroys diffuse liver metastases from colon carcinoma . FASEB J . 2000;14:301–311
  51. Wildner O , Blaese RM , Morris JC . Therapy of colon cancer with oncolytic adenovirus is enhanced by the addition of herpes simplex virus-thymidine kinase . Cancer Res . 1999;59:410–413
  52. Pawlik TM , Nakamura H , Mullen JT , et al.   Prodrug bioactivation and oncolysis of diffuse liver metastases by a herpes simplex virus 1 mutant that expresses the CYP2B1 transgene . Cancer . 2002;95:1171–1181
  53. Sobiati L . Hepatic metastases (Percutaneous radio-frequency ablation with cooled-tip electrodes) . Radiology . 1997;205:367–373
  54. Curley SA , Izzo F , Delrio P , et al.   Radiofrequency ablation of unresectable primary and metastatic hepatic malignancies. Results in 123 patients . Ann Surg . 1999;230:1–8
  55. Siperstein A , Garland A , Engle K , et al.   Local recurrence after laparoscopic radiofrequency thermal ablation of hepatic tumors . Ann Surg Oncol . 2000;7:106–113
  56. Iannitti DA , Dupuy DE , Mayo-Smith WW , et al.   Hepatic radiofrequency ablation . Arch Surg . 2000;137:422–426
  57. Weaver ML , Ashton JG , Zemel R . Treatment of colorectal liver metastases by cryotherapy . Semin Surg Oncol . 1998;14:163–170
  58. Seifert JK , Morris DL . Prognostic factors after cryotherapy for hepatic metastases from colorectal cancer . Ann Surg . 1998;228:201–208
  59. Wallace JR , Chrisitans KK , Pitt HA , et al.   Cryotherapy extends the indications for treatment of colorectal liver metastases . Surgery . 1999;126:766–774
  60. Livraghi T , Vettori C , Lazzaroni S . Liver metastases (Results of percutaneous ethanol injection in 14 patients) . Radiology . 1991;179:709–712
  61. Amin Z , Brown SG , Lees WR . Local treatment of colorectal liver metastases (A comparison of intersititial laser photocoagulation (ILP) and percutaneous alcohol injection (PAI)) . Clin Radiol . 1993;179:709–712
  62. Giovannini M , Seitz J . Ultrasound-guided percutaneous alcohol injection of small liver metastases. Results in 40 patients . Cancer . 1994;73:294–297
  63. Giorgio A , Tarantino L , Mariniello N . Ultrasonography-guided percutaneous ethanol injection in large and or multiple liver metastases . Radiol Med . 1998;96:238–242
  64. Grage TB , Vassilopoulos PP , Shingleton WW , et al.   Results of a prospective randomized study of hepatic artery infusion with 5-fluorouracil versus intravenous 5-fluorouracil in patients with hepatic metastases form colorectal cancer (A Central Oncology Group study) . Surgery . 1979;86:550–555
  65. Kemeny N , Daly J , Reichman B , et al.   Intrahepatic or systemic infusion of fluorodeoxyuridine in patients with liver metastases from colorectal carcinoma. A randomized trial . Ann Intern Med . 1987;107:459–465
  66. Chang AE , Schneider PD , Sugarbaker PH , et al.   A prospective randomized trial of regional versus systemic continuous 5-fluorodeoxyuridine chemotherapy in the treatment of colorectal liver metastases . Ann Surg . 1987;206:685–693
  67. Hohn DC , Stagg RJ , Friedman MA , et al.   A randomized trial of continuous intravenous versus hepatic intraarterial floxuridine in patients with colorectal cancer metastatic to the liver (The Northern California Oncology Group trial) . J Clin Oncol . 1989;7:1646–1654
  68. Martin JK , O’Connell MJ , Wieand HS , et al.   Intra-arterial floxuridine vs systemic fluorouracil for hepatic metastases from colorectal cancer. A randomized trial . Arch Surg . 1990;125:1022–1027
  69. Wagman LD , Kemeny MM , Leong L , et al.   A prospective, randomized evaluation of the treatment of colorectal cancer metastatic to the liver . J Clin Oncol . 1990;8:1885–1893
  70. Rougier P , Laplanche A , Huguier M , et al.   Hepatic arterial infusion of floxuridine in patients with liver metastases from colorectal carcinoma (Long-term results of a prospective randomized trial) . J Clin Oncol . 1992;10:1112–1118
  71. Allen-Mersh TG , Earlam S , et al.   Quality of life and survival with continuous hepatic-artery floxuridine infusion for colorectal liver metastases . Lancet . 1994;344:1255–1260

PII: S0093-7754(04)00454-3

doi: 10.1053/j.seminoncol.2004.09.025

Seminars in Oncology
Volume 32, Issue 1 , Pages 85-94 , February 2005

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