Seminars in Oncology
Volume 32, Issue 3 , Pages 284-292 , June 2005

Current Standards and Ongoing Controversies in the Management of Locally Advanced Non-Small Cell Lung Cancer

  • Howard West

      Affiliations

    • Swedish Cancer Institute, Seattle, WA
    • Corresponding Author InformationAddress reprint requests to Howard (Jack) West, MD, Swedish Cancer Institute, 1221 Madison St, Second Floor, Seattle, WA 98104
  • ,
  • Kathy S. Albain

      Affiliations

    • Loyola University Medical Center, Maywood, IL

References 

  1. Pass HI , Pogrebniak HW , Steinberg SM , et al.   Randomized trial of neoadjuvant therapy for lung cancer (Interim analysis) . Ann Thorac Surg . 1992;53:992–998
  2. Rosell R , Gomez-Codina J , Camps C , et al.   A randomized trial comparing preoperative chemotherapy plus surgery with surgery alone in patients with non-small cell lung cancer . N Engl J Med . 1994;330:153–158
  3. Roth JA , Fosella F , Komaki R , et al.   A randomized trial comparing perioperative chemotherapy and surgery with surgery alone in resectable stage IIIA non-small cell lung cancer . J Natl Cancer Inst . 1994;86:673–680
  4. Mountain CF . Revisions in the International System for Staging Lung Cancer . Chest . 1997;111:1710–1717
  5. Depierre A , Milleron B , Moro-Sibilot D , et al.   Preoperative chemotherapy followed by surgery compared with primary surgery in resectable stage I (except T1N0), II, and IIIa non-small-cell lung cancer . J Clin Oncol . 2002;20:247–253
  6. Nagai K , Tsuchiya R , Mori T , et al.   A randomized trial comparing induction chemotherapy followed by surgery with surgery alone for patients with stage IIIA N2 non-small cell lung cancer (JCOG 9209) . J Thorac Cardiovasc Surg . 2003;125:254–260
  7. Albain KS , Rusch VW , Crowley JJ , et al.   Concurrent cisplatin/etoposide plus chest radiotherapy followed by surgery for stages IIIA (N2) and IIIB non-small-cell lung cancer (Mature results of Southwest Oncology Group phase II study 8805) . J Clin Oncol . 1995;13:1880–1892
  8. MacManus MP , Hicks RJ , Matthews JP , et al.   Positron emission tomography is superior to computed tomography scanning for response-assessment after radical radiotherapy or chemoradiotherapy in patients with non-small-cell lung cancer . J Clin Oncol . 2003;21:1285–1292
  9. Albain KS , Scott CB , Rusch VR , et al.   Phase III study of concurrent chemotherapy and full course radiotherapy (CT/RT) versus CT/RT induction followed by surgical resection for stage IIIA (pN2) non-small cell lung cancer (NSCLC) (First outcome analysis of North American Intergroup trial 0139 (RTOG 93-09)) . Lung Cancer . 2003;41(suppl 2):S4; (abstr PL-4)
  10. Dillman RO , Seagren SL , Propert KJ , et al.   A Randomized trial of induction chemotherapy plus high-dose radiation versus radiation alone in stage III non-small cell lung cancer . N Engl J Med . 1990;323:940–945
  11. Dillman RO , Herndon J , Seagren SL , et al.   Improved survival in stage III non-small-cell lung cancer (seven-year follow-up of Cancer and Leukemia Group B (CALGB) 8433 trial) . J Natl Cancer Inst . 1996;88:1210–1215
  12. Schaake-Koning C , Van den Bogaert W , Dalesio O , et al.   Effects of concomitant cisplatin and radiotherapy on inoperable non-small cell lung cancer . N Engl J Med . 1992;326:524–530
  13. Sause W , Kolesar P , Taylor S , et al.  Radiation Therapy Oncology Group  Eastern Cooperative Oncology Group  Southwest Oncology Group   Final results of phase III trial in regionally advanced unresectable non-small cell lung cancer . Chest . 2000;117:358–364
  14. Saunders M , Dische S , Barrett A , et al.   Continuous, hyperfractionated, accelerated radiotherapy (CHART) versus conventional radiotherapy in non-small cell lung cancer (Mature data from the randomised multicentre trial) . Radiother Oncol . 1999;52:137–148
  15. Furuse K , Fukuoka M , Kawahara M , et al.   Phase III study of concurrent versus sequential thoracic radiotherapy in combination with mitomycin, vindesine, and cisplatin in unresectable stage III non-small cell lung cancer . J Clin Oncol . 1999;17:2692–2699
  16. Curran WJ, Scott CB, Langer CJ, et al: Long-term benefit is observed in a phase III comparison of sequential vs concurrent chemo-radiation for patients with unresected stage III NSCLC: RTOG 9410. J Clin Oncol (in press)
  17. Huber RM , Schmidt M , Flentje M , et al.   Induction chemotherapy and following simultaneous radio/chemotherapy versus induction chemotherapy and radiotherapy alone in inoperable NSCLC (stage IIIA/IIIB) . Proc Am Soc Clin Oncol . 2003;22:622; (abstr 2501)
  18. Mornex F , Robinet G , Thomas P , et al.   Sequential versus concurrent chemo-radiation (RT-CT) in locally advanced non small cell lung cancer (NSCLC) (A French randomized phase III trial of GLOT-GFPC (NPC 95-01 study)) . Eur J Cancer . 2001;37(suppl 6):S28; (abstr 93)
  19. Zatloukal O , Petruzelka L , Zemanova M , et al.   Concurrent versus sequential radiochemotherapy with vinorelbine plus cisplatin in locally advanced non-small cell lung cancer (A randomized phase II study - long term follow-up data) . Lung Cancer . 2003;41(suppl 2):S76; (abstr 0-262)
  20. Belani CP , Wang W , Johnson DH , et al.   Induction chemotherapy followed by standard thoracic radiotherapy (Std.TRT) vs. hyperfractionated accelerated radiotherapy (HART) for patients with unresectable stage III A and B non-small cell lung cancer (NSCLC) (Phase III study of the Eastern Cooperative Oncology Group (ECOG 2597)) . Proc Am Soc Clin Oncol . 2003;22:622; (abstr 2500)
  21. Choy H . Locally advanced NSCLC (Recent innovations and current paradigms) . 2003; Presented at the American Society for Clinical Oncology Annual Meeting, Chicago, IL, May
  22. Vokes EE , Herndon JE , Crawford J , et al.   Randomized phase II study of cisplatin with gemcitabine or paclitaxel or vinorelbine as induction chemotherapy followed by concomitant chemoradiotherapy for stage IIIB non-small cell lung cancer (Cancer and Leukemia Group B study 9431) . J Clin Oncol . 2002;20:4191–4198
  23. Vokes EE , Herndon JE , Kelley MJ , et al.   Induction chemotherapy followed by concomitant chemoradiotherapy (CT/XRT) versus CT/XRT alone for regionally advanced unresectable non-small cell lung cancer (NSCLC) (Initial analysis of a randomized phase III trial) . Proc Am Soc Clin Oncol . 2004;23:616; (abstr 7005)
  24. Socinski MA , Rosenman JG , Halle J , et al.   Dose-escalating conformal thoracic radiation therapy with induction and concurrent carboplatin/paclitaxel in unresectable stage IIIA/B nonsmall cell lung carcinoma . Cancer . 2001;92:1213–1223
  25. Albain KS , Crowley JJ , Turrisi AT , et al.   Concurrent cisplatin, etoposide, and chest radiotherapy in pathologic stage IIIB non-small cell lung cancer (A Southwest Oncology Group phase II study, SWOG 9019) . J Clin Oncol . 2002;20:3454–3460
  26. Gandara DR , Chansky K , Albain KS , et al.   Consolidation docetaxel after concurrent chemoradiotherapy in stage IIIB non-small-cell lung cancer (Phase II Southwest Oncology Group study S9504) . J Clin Oncol . 2003;21:2004–2010
  27. Choy H , Curran WJ , Scott CB , et al.   Preliminary report of the locally advanced multimodality protocol (LAMP): ACR 427: A randomized phase II study of three chemo-radiation regimens with paclitaxel, carboplatin, and throacic radiation (TRT) for patients with locally advanced non-small cell lung cancer (LA-NSCLC) . Proc Am Soc Clin Oncol . 2002;21:291; (abstr 1160)
  28. Sause WT , Scott C , Taylor S , et al.   Radiation Therapy Oncology Group (RTOG) 88-08 and Eastern Cooperative Oncology Group (ECOG) 4588 (Preliminary results of a phase III trial in regionally advanced, unresectable non-small-cell lung cancer) . J Natl Cancer Inst . 1995;87:198–205
  29. Lau DH , Crowley JJ , Gandara DR , et al.   Southwest Oncology Group phase II trial of concurrent carboplatin, etoposide, and radiation for poor-risk stage III non-small-cell lung cancer . J Clin Oncol . 1998;16:3078–3081
  30. Davies A , Lau D , Crowley J , et al.   Concurrent carboplatin/etoposide and radiation followed by paclitaxel consolidation for poor risk stage III non-small cell lung cancer (A Southwest Oncology Group (SWOG) phase II trial (S9712)) . Proc Am Soc Clin Oncol . 2002;21:298a; (abstr 1191)

PII: S0093-7754(05)00084-9

doi: 10.1053/j.seminoncol.2005.02.015

Seminars in Oncology
Volume 32, Issue 3 , Pages 284-292 , June 2005