Current Management of Advanced Non-Small Cell Lung Cancer: Targeted Therapy

Representative samples of immunofluorescent histology of CD31 and EGFR in human adenocarcinoma of the lung. (A) Double-labeling for CD31 and EGFR to study expression of receptor on tumor-associated endothelial cells. (B) EGFR expression on tumor cells. Red: CD31⁺ endothelial cells; green: EGFR⁺ cells; yellow: EGFR⁺ endothelial cells (arrows); blue: nuclear staining (original magnification, ×400). In this particular tumor, both tumor cells and tumor-associated endothelial cells express EGFR.

Immunohistochemical analysis of growth factor and angiogenesis-related genes in primary and metastatic tumors. The expression patterns differ by histologic type and metastasis site.

New paradigm for the use of biologic therapy for advanced lung cancer.