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Seminars in Oncology
Volume 32, Issue 3
, Pages 315-328
, June 2005
Current Management of Advanced Non-Small Cell Lung Cancer: Targeted Therapy
References
- Cancer statistics, 2005 . CA Cancer J Clin . 2005;55:10–30
-
.
Chemotherapy for advanced non-small-cell lung cancer
(Who, what, when, why?)
.
J Clin Oncol
. 2002;20(suppl 18):23s–33s
-
.
Targeting the epidermal growth factor receptor for cancer therapy
.
J Clin Oncol
. 2002;20(suppl 18):1s–13s
- . Developing inhibitors of the epidermal growth factor receptor for cancer treatment . J Natl Cancer Inst . 2003;95:851–867
- . Clinical translation of angiogenesis inhibitors . Nat Rev Cancer . 2002;2:727–739
-
.
Specialization of tumour vasculature
.
Nat Cancer Rev
. 2002;2:83–90
- . Cell signaling by receptor tyrosine kinases . Cell . 2000;103:211–225
- . The ErbB signaling network (Receptor heterodimerization in development and cancer) . EMBO J . 2000;19:3159–3167
- Expression of epidermal growth factor receptor (EGF-R) in non-small cell lung cancer. Use of archival tissue and correlation of EGF-R with histology, tumour size, node status and survival . Br J Cancer . 1989;59:746–749
- Prognostic influence of the co-expression of epidermal growth factor receptor and c-erbB-2 protein in human lung adenocarcinoma . Surg Oncol . 1994;3:109–113
- Immunocytochemical markers in stage I lung cancer (Relevance to prognosis) . J Clin Oncol . 1997;15:2858–2865
- Overexpression of the epidermal growth factor receptor and its ligand transforming growth factor alpha is frequent in resectable non-small cell lung cancer but does not predict tumor progression . Clin Cancer Res . 1997;3:515–522
- Do molecular markers predict survival in non-small-cell lung cancer? . Am J Respir Crit Care Med . 1998;157:1093–1097
- Enzyme-linked immunosorbent assay of epidermal growth factor receptor in lung cancer (Comparisons with immunohistochemistry, clinicopathological features and prognosis) . Br J Cancer . 1998;78:96–99
- . Prognostic value of ERBB-1, VEGF, cyclin A, FOS, JUN and MYC in patients with squamous cell lung carcinomas . Br J Cancer . 1998;77:663–669
- Evaluation of epidermal growth factor-related growth factors and receptors and of neoangiogenesis in completely resected stage I-IIIA non-small-cell lung cancer (Amphiregulin and microvessel count are independent prognostic indicators of survival) . Clin Cancer Res . 1998;4:241–249
- Study of prognostic predictors for non-small cell lung cancer . Lung Cancer . 1999;23:143–152
- A biologic risk model for stage I lung cancer (Immunohistochemical analysis of 408 patients with the use of ten molecular markers) . J Thorac Cardiovasc Surg . 1999;117:736–743
- Epidermal growth factor receptor expression correlates with poor prognosis in non-small cell lung cancer patients with p53 overexpression . Oncol Rep . 2000;7:603–607
- . Matrix metalloproteinase 9 and the epidermal growth factor signal pathway in operable non-small cell lung cancer . Clin Cancer Res . 2000;6:2349–2355
- Immunohistochemical analysis of epidermal growth factor receptor family members in stage I non-small cell lung cancer . Ann Thorac Surg . 2001;72:1868–1876
- Phosphorylation, but not overexpression, of epidermal growth factor receptor is associated with poor prognosis of non-small cell lung cancer patients . Oncol Res . 2003;13:289–298
- Epidermal growth factor receptor in non-small-cell lung carcinomas (Correlation between gene copy number and protein expression and impact on prognosis) . J Clin Oncol . 2003;21:3798–3807
- Synchronous overexpression of epidermal growth factor receptor and HER2-neu protein is a predictor of poor outcome in patients with stage I non-small cell lung cancer . Clin Cancer Res . 2004;10:136–143
- Amplification and overexpression of the cyclin D1 and epidermal growth factor receptor genes in non-small-cell lung cancer . J Cancer Res Clin Oncol . 1999;125:61–70
- The role of EGF-R expression on patient survival in lung cancer (A systematic review with meta-analysis) . Eur Respir J . 2002;20:975–981
- The type III epidermal growth factor receptor mutation . Ann Oncol . 2001;12:745–760
- Activating mutations in the epidermal growth factor receptor underlying responsiveness fo non-small-cell lung cancer to gefitinib . N Engl J Med . 2004;350:2129–2139
- EGFR mutations in lung cancer (Correlation with clinical response to gefitinib therapy) . Science . 2004;304:1497–1500
- . Status of epidermal growth factor receptor antagonists in the biology and treatment of cancer . J Clin Oncol . 2003;21:2787–2799
- . Epidermal growth factor receptors as a target for cancer treatment (The emerging role of IMC-C225 in the treatment of lung and head and neck cancers) . Semin Oncol . 2002;29:27–36
-
Phase IB/IIIA study of anti-epidermal growth factor receptor antibody, cetuximab, in combination with gemcitabine/carboplatin in patients with advanced stage IV non-small cell lung cancer
.
Proc Am Soc Clin Oncol
. 2003;22:643;
(abstr)
-
A multicenter phase I/II study of anti-epidermal growth factor receptor antibody, cetuximab, in combination with paclitaxel and carboplatin in patients with IV non-small cell lung cancer
.
Proc Am Soc Clin Oncol
. 2003;22:644;
(abstr)
-
A phase II study of cetuximab, an epidermal growth factor receptor (EGFR) blocking antibody, in combination with docetaxel in chemotherapy refractory/resistant patients with advanced non-small cell lung cancer
(Final report)
.
Proc Am Soc Clin Oncol
. 2003;22:642;
(abstr)
-
Cetuximab (Erbitux) in combination with cisplatin/vinorelbine vs cisplatin/vinorelbine alone in the first-line treatment of patients with epidermal growth factor receptor-expressing advanced non-small cell lung cancer
.
Proc Am Soc Clin Oncol
. 2003;22:642;
(abstr)
-
Randomized phase II study of cetuximab in combination with cisplatin (C) and vinorelbine (V) vs. CV alone in the first-line treatment of patients (pts) with epidermal growth factor receptor (EGFR)-expressing advanced non-small-cell lung cancer (NSCLC)
.
Proc Am Soc Clin Oncol
. 2004;23:618a
- . ZD1839 (Iressa) in non-small cell lung cancer . Oncologist . 2002;7(suppl 4):9–15
- . Erlotinib (Tarceva) (An update on the clinical trial program) . Semin Oncol . 2003;30(suppl 7):34–46
- Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer . J Clin Oncol . 2003;21:2237–2246
- Efficacy of gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic patients with non-small cell lung cancer (A randomized trial) . JAMA . 2003;290:2149–2158
- . Targeting epidermal growth factor receptor—Are we missing the mark? . Lancet . 2003;362:62–64
- Gefitinib (ZD1839) in combination with gemcitabine and cisplatin in advanced non-small-cell lung cancer (A phase III trial (INTACT 1)) . J Clin Oncol . 2004;22:777–784
- Gefitinib (ZD1839) in combination with paclitaxel and carboplatin in advanced non-small-cell lung cancer (A phase III trial (INTACT 2)) . J Clin Oncol . 2004;22:785–794
-
Results of a phase III trial of erlotinib (OSI-774) combined with cisplatin and gemcitabine (GC) chemotherapy in advanced non-small cell lung cancer
.
Proc Am Soc Clin Oncol
. 2004;22:7010
-
TRIBUTE—A phase III trial of erlotinib HCl (OSI-774) combined with carboplatin and paclitaxel (CP) chemotherapy in advanced non-small cell lung cancer
.
Proc Am Soc Clin Oncol
. 2004;22:7011
-
A randomized placebo-controlled trial of erlotinib in patients with non-small cell lung cancer (NSCLC) following failure of 1st line or 2nd line chemotherapy. A National Cancer Institute of Canada Clinical Trials Group (NCIC CTG) trial
.
J Clin Oncol
. 2004;22:145
-
.
Epidermal growth factor receptor mutations, small-molecule kinase inhibitors, and non-small-cell lung cancer
(Current knowledge and future directions)
.
J Clin Oncol
. 2005;23:2268–2556
- Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers . J Natl Cancer Inst . 2005;97:339–346
- Inhibitory effects of combinations of HER-2/neu antibody and chemotherapeutic agents used for treatment of human breast cancers . Oncogene . 1999;18:2241–2251
-
Trastuzumab in combination with paclitaxel/carboplatin advanced non-small cell lung cancer
(Final report of ECOG 2598)
.
Proc Am Soc Clin Oncol
. 2003;22:648;
(abstr)
- Randomized phase II trial of gemcitabine-cisplatin with or without trastuzumab in HER2-positive non-small-cell lung cancer . Ann Oncol . 2004;15:19–27
- . Non-small cell lung cancer clinical trials with trastuzumab (their foundation and preliminary results) . Lung Cancer . 2002;37:17–27
- . K-ras oncogene mutation as a prognostic marker in non-small cell lung cancer (A combined analysis of 881 cases) . Carcinogenesis . 1999;20:1507–1510
- . Ras signaling and apoptosis . Curr Opin Genet Dev . 1998;8:9–54
- . An overview of farnesyltransferase inhibitors and their role in lung cancer therapy . Lung Cancer . 2003;41:55–62
-
Web page accessed 2/5/04: http://www.schering-plough.com/schering-plough/news/release.jsp?releaseID=492402
- . Development of matrix metalloproteinase inhibitors in cancer therapy . J Natl Cancer Inst . 2001;93:178–193
- Pretreatment serum levels of matrix metalloproteinase-9 and vascular endothelial growth factor in non-small-cell lung cancer . Ann Oncol . 2002;13:1550–1557
-
Phase III study of the matrix metalloprotease (MMP) inhibitor prinomastat in patients having advanced non-small cell lung cancer
.
Proc Am Soc Clin Oncol
. 2001;20:307;
(abstr)
-
Phase III study of the matrix metalloprotease inhibitor prinomastat in combination with gemcitabine and cisplatin in non-small cell lung cancer
.
Proc Am Soc Clin Oncol
. 2002;21:296;
(abstr)
-
Phase I/II trials on the safety, tolerability and efficacy of Æ-941 (Neovastat) in patients with solid tumors
.
Proc Am Soc Clin Oncol
. 2001;20:277;
(abstr)
-
Randomized phase II-III study of matrix metalloproteinase inhibitor (MMPI) BMS-275291 in combination with paclitaxel (P) and carboplatin (C) in advanced non-small cell lung cancer (NSCLC)
(NCIC-CTG BR.18)
.
J Clin Oncol
. 2004;22(suppl):
(abstr)
- . Protein kinase C inhibitors . Curr Oncol Rep . 2002;4:37–46
-
Phase I/II trial of ISIS 3521, an antisense inhibitor of PKC-alpha, with carboplatin and paclitaxel in non-small cell lung cancer
.
Proc Am Soc Clin Oncol
. 2001;19:167;
(abstr)
-
Phase I/II trial of ISIS 3521/LY900003, an antisense inhibitor of PKC-alpha with cisplatin and gemcitabine in advanced non-small cell lung cancer
.
Proc Am Soc Clin Oncol
. 2002;21:1233;
(abstr)
-
A. Randomized phase III trial of chemotherapy and antisense oligonucleotide LY900003 (ISIS 3521) in patients with advanced NSCLC: Initial report
.
Proc Am Soc Clin Oncol
. 2003;22:623;
(abstr)
- . The retinoid signaling pathway (molecular and genetic analyses) . Semin Cell Biol . 1994;5:115–125
- Randomized phase III intergroup trial of isotretinoin to prevent second primary tumors in stage I non-small-cell lung cancer . J Natl Cancer Inst . 2001;93:605–618
- Multi-institutional phase I/II trial of oral bexarotene in combination with cisplatin and vinorelbine in previously untreated patients with advanced non-small-cell lung cancer . J Clin Oncol . 2001;19:2626–2637
- . Tumor angiogenesis (Therapeutic implications) . N Engl J Med . 1971;285:1182–1186
-
.
Tumorigenesis and the angiogenic switch
.
Nat Rev
. 2003;3:401–410
- . Angiogenesis in cancer, vascular, rheumatoid and other disease . Nat Med . 1995;1:27–31
- . A highly conserved vascular permeability factor secreted by a variety of human and rodent tumor cell lines . Cancer Res . 1986;46:5629–5632
- Significance of vascular endothelial growth factor messenger RNA expression in primary lung cancer . Clin Cancer Res . 1996;2:1411–1416
- Prognostic value of vascular endothelial growth factor and its receptor Flt-1 in squamous cell lung cancer . Int J Cancer . 1997;74:64–68
- Vascular endothelial growth factor expression in non-small-cell lung cancer (Prognostic significance in squamous cell carcinoma) . J Thorac Cardiovasc Surg . 1998;115:1007–1014
- . Tumor angiogenesis and vascular endothelial growth factor expression in stage I lung adenocarcinoma . Clin Cancer Res . 1998;4:1483–1487
- Vascular endothelial growth factor, wild-type p53, and angiogenesis in early operable non-small cell lung cancer . Clin Cancer Res . 1998;4:3017–3024
- Bcl2 and p53 regulate vascular endothelial growth factor (VEGF)-mediated angiogenesis in non-small cell lung carcinoma . Eur J Cancer . 1998;34:718–723
- Immunohistochemical study on tumor angiogenic factors in non-small cell lung cancer . Anticancer Res . 1999;19:4305–4309
- . PD-ECGF, bFGF, and VEGF expression in non-small cell lung carcinomas and their association with lymph node metastasis . Anticancer Res . 1999;19:651–655
- Tumor angiogenesis and recurrence in stage I non-small cell lung cancer . Ann Thorac Surg . 1999;68:1034–1038
- Vascular endothelial growth factor and osteopontin in stage I lung adenocarcinoma . Am J Respir Crit Care Med . 1999;160:1269–1273
- Vascular endothelial growth factor expression and neovascularisation in non-small cell lung cancer . Eur J Cancer . 2000;36:601–609
- The intratumoral expression of vascular endothelial growth factor and interleukin-8 associated with angiogenesis in non-small cell lung carcinoma patients . Cancer . 2001;92:2628–2638
- Immune function, telomerase, and angiogenesis in patients with primary, operable non-small cell lung carcinoma (Tumor size and lymph node status remain the most important prognostic features) . Cancer . 2001;92:2648–2657
- Prognostic value of vascularity and vascular endothelial growth factor expression in non-small cell lung cancer . J Clin Pathol . 2001;54:116–120
- Vascular endothelial growth factor expression in stage I non-small cell lung cancer correlates with neoangiogenesis and a poor prognosis . Ann Surg Oncol . 2001;8:72–79
- Prognostic significance of p53, Ki-67, VEGF and Glut-1 in resected stage I adenocarcinoma of the lung . Lung Cancer . 2002;38:51–57
-
.
The biology of VEGF and its receptors
.
Nature Med
. 2003;9:669–676
- Lymphangiogenesis and cancer metastasis . Nat Rev Cancer . 2002;2:573–583
- . Mechanisms and future directions for angiogenesis-based cancer therapies . J Clin Oncol . 2002;20:3906–3927
- . Angiogenesis inhibitors in lung cancer . Curr Oncol Rep . 2002;4:325–333
- Angiogenesis inhibitors in clinical development for lung cancer . Semin Oncol . 2002;29(suppl 4):66–77
- Humanization of an anti-vascular endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disorders . Cancer Res . 1997;57:4593–4599
- Phase Ib trial of intravenous recombinant humanized monoclonal antibody to vascular endothelial growth factor in combination with chemotherapy in patients with advanced cancer (Pharmacologic and long-term safety data) . J Clin Oncol . 2001;19:851–856
- Phase I safety and pharmachokinetic study of recombinant human anti-vascular endothelial growth factor in patients with advanced cancer . J Clin Oncol . 2001;19:843–850
- Randomized phase II trial comparing bevacizumab plus carboplatin and paclitaxel with carboplatin and paclitaxel alone in previously untreated locally advanced metastatic non-small-cell lung cancer . J Clin Oncol . 2004;22:2184–2191
- Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer . N Engl J Med . 2004;350:2335–2342
- A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer . N Engl J Med . 2003;349:427–434
- SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types . Cancer Res . 1999;59:99–106
-
Dose-finding and pharmacokinetic study of cisplatin, gemcitabine, and SU5416 in patients with solid tumors
.
J Clin Oncol
. 2002;15:1657–1667
-
ZD6474, a small molecule targeting VEGF and EGF receptor signaling, inhibits lung angiogenesis and metastasis and improves survival in an orthotopic model of non-small cell lung cancer
.
Proc Am Assoc Cancer Research
. 2004;
-
Clinical evaluation of ZD6474, an orally active inhibitor of VEGF signaling in patients with solid tumors
.
Proc Am Soc Clin Oncol
. 2002;21:82;
(abstr)
-
A phase I study of an oral VEGF receptor tyrosine kinase inhibitor ZD6474, in Japanese patients with solid tumors
.
Proc Am Soc Clin Oncol
. 2003;21:194;
(abstr)
- ZD6126 (A novel vascular-targeting agent that causes selective destruction of tumor vasculature) . Cancer Res . 2002;62:7247–7253
- Activity of a new vascular targeting agent, ZD6126, in pulmonary metastases by human lung adenocarcinoma in nude mice . Cancer Res . 2002;62:3711–3715
-
A dose-escalation study of the novel vascular-targeting agent, ZD6126, in patients with solid tumors
.
Proc Am Soc Clin Oncol
. 2002;21:110a;
(abstr)
- Endostatin (An endogenous inhibitor of angiogenesis and tumor growth) . Cell . 1997;88:277–285
- Phase I study of recombinant human endostatin in patients with advanced solid tumors . J Clin Oncol . 2002;20:3792–3803
- Phase I/II trial evaluating the anti-vascular endothelial growth factor monoclonal antibody bevacizumab in combination with the HER-1/epidermal growth factor receptor tyrosine kinase inhibitor erlotinib for patients with recurrent non-small-cell lung cancer . J Clin Oncol . 2005;23:2544–2555
- The effect of celecoxib, a cyclooxygenase-2 inhibitor, in familial adenomatous polyposis . N Engl J Med . 2000;342:1946–1952
- Cyclooxygenase-2 inhibitor induces apoptosis and enhances cytotoxicity of various anticancer agents in non-small cell lung cancer cell lines . Clin Cancer Res . 2000;6:2006–2011
-
.
Celecoxib (Celebrex), a selective COX-2 inhibitor, enhances the response to preoperative paclitaxel/carboplatin in early stage non-small cell lung cancer
.
Proc Am Soc Clin Oncol
. 2002;21:26;
(abstr)
-
Cyclooxygenase-2 (COX-2) inhibition + docetaxel (Txt) in recurrent non-small cell lung cancer (NSCLC)
(Preliminary results of a phase II trial (THO-0054))
.
Proc Am Soc Clin Oncol
. 2002;21:1187;
(abstr)
- . The microenvironment of the tumor-host interface . Nature . 2001;411:375–379
- . The organ microenvironment and cancer metastasis . Differentiation . 2002;70:498–505
- . Clinical trial design for target-based therapy . Oncologist . 2002;7:401–409
-
.
For investigational targeted drugs, combination trials pose challenges
.
J Natl Cancer Inst
. 2003;95:1744–1746
- Blockade of epidermal growth factor receptor signaling on tumor cells and tumor-associated endothelial cells for therapy of human carcinomas . Am J Pathol . 2002;161:929–938
- Epidermal growth factor receptor and HER2-neu mRNA expression in non-small cell lung cancer is correlated with survival . Clin Cancer Res . 2001;7:1850–1855
-
Phase I/II study of the recombinant humanized monoclonal anti-VEGF antibody bevacizumab and the EGFR-TK inhibitor erlotinib in patients with recurrent non-small cell lung cancer
.
Proc Am Soc Clin Oncol
. 2003;22:627;
(abstr)
- Development of an orthotopic model to study the biology and therapy of primary human lung cancer in nude mice . Clin Cancer Res . 2003;9:5532–5539
PII: S0093-7754(05)00086-2
doi: 10.1053/j.seminoncol.2005.02.016
© 2005 Elsevier Inc. All rights reserved.
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Seminars in Oncology
Volume 32, Issue 3
, Pages 315-328
, June 2005
