Seminars in Oncology
Volume 33, Issue 1 , Pages 68-73, February 2006

Renal Toxicities of Chemotherapy

  • Maja J.A. de Jonge

      Affiliations

    • Corresponding Author InformationAddress correspondence to Maja J.A. de Jonge, Erasmus University Medical Center/ Daniel den Hoed Cancer Center, Department of Medical Oncology, Groene Hilledijk 301, 3075 EA Rotterdam, The Netherlands
    • ,
  • Jaap Verweij

Department of Medical Oncology, Erasmus Medical Center/Daniel den Hoed Cancer Center, Rotterdam, The Netherlands

Chemotherapeutic agents can produce a variety of acute and chronic organ toxicities. Since many antitumor drugs and their metabolites are cleared renally, the kidneys are vulnerable to injury. The drugs involved will determine the site of injury within the kidney, resulting in clinical manifestations ranging from an asymptomatic rise in serum creatinine to acute renal failure. The most common renal toxicities of chemotherapeutic agents are described.

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PII: S0093-7754(05)00432-X

doi:10.1053/j.seminoncol.2005.11.011

Seminars in Oncology
Volume 33, Issue 1 , Pages 68-73, February 2006

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