Seminars in Oncology
Volume 33 , Pages 3-6 , February 2006

Biological Insights into the Pathogenesis of Cutaneous T-Cell Lymphomas (CTCL)

  • Sean Whittaker

      Affiliations

    • Corresponding Author InformationAddress correspondence and reprint requests to Sean Whittaker, MD, FRCP, St Johns Institute of Dermatology (St Thomas’ Campus), Guys and St Thomas’ Hospital, London, SE1 7EH United Kingdom

References 

  1. Yawalkar N , Ferenczi K , Jones DA , et al.   Profound loss of T-cell receptor repertoire complexity in cutaneous T-cell lymphoma . Blood . 2003;102:4059–4066
  2. Berger CL , Tigelaar R , Cohen J , et al.   Cutaneous T cell lymphoma (Malignant proliferation of T-regulatory cells) . Blood . 2005;15:1640–1647
  3. Karenko L , Kahkonen M , Hyytinen ER , et al.   Notable losses at specific regions of chromosomes 10q and 13q in the Sezary syndrome detected by comparative genomic hybridization . J Invest Dermatol . 1999;112:392–395
  4. Karenko L , Nevala H , Raatikainen M , et al.   Chromosomally clonal T cells in the skin, blood, or lymph nodes of two Sezary syndrome patients express CD45RA, CD45RO, CDw150, and interleukin-4, but no interleukin-2 or interferon-gamma . J Invest Dermatol . 2001;116:188–193
  5. Mao X , Orchard G , Lillington DM , et al.   Genetic alterations in primary cutaneous CD30+ anaplastic large cell lymphoma . Genes Chromosomes Cancer . 2003;37:176–185
  6. Karenko L , Hahtola S, Paivinen S , et al.   Primary cutaneous T-cell lymphomas show a deletion or translocation affecting NAV3, the human virus homologue . Cancer Res . 2005;65:8101–8110
  7. Scarisbrick JJ , Mitchell TJ , Calonje E , et al.   Microsatellite instability is associated with hypermethylation of the hMLH1 gene and reduced gene expression in mycosis fungoides . J Invest Dermatol . 2003;121:894–901
  8. Mao X , Lillington DM , Scarisbrick JJ , et al.   Molecular cytogenetic analysis of cutaneous T-cell lymphomas (Identification of common genetic alterations in Sezary syndrome and mycosis fungoides) . Br J Dermatol . 2002;147:464–475
  9. Fischer T , Gellrich S , Muche M , et al.   Genomic aberrations and survival in cutaneous T-cell lymphomas . J Invest Dermatol . 2004;122:579–586
  10. Scarisbrick JJ , Woolford AJ , Russell-Jones R , et al.   Allelotyping in mycosis fungoides and Sezary syndrome (Common regions of allelic loss identified on 9p, 10q, and 17p) . J Invest Dermatol . 2001;117:663–670
  11. Wain EM , Mitchell TJ , Russell  , et al.   Fine mapping of chromosome 10q deletions in mycosis fungoides and Sezary syndrome (Identification of two discrete regions of deletion at 10q23.33-24.1 and 10q24.33-25.1) . Genes Chromosomes Cancer . 2005;42:184–192 ??
  12. Kari L , Loboda A , Nebozhyn M , et al.   Classification and prediction of survival in patients with the leukemic phase of cutaneous T cell lymphoma . J Exp Med . 2003;197:1477–1488
  13. Su MW , Dorocicz I , Dragowska W , et al.   Aberrant expression of T-Plastin in Sezary cells . Cancer Res . 2003;63:7122–7127
  14. van Doorn R , Dijkman R , Vermeer MH , et al.   Aberrant expression of the tyrosine kinase receptor EphA4 and the transcription factor twist in Sezary syndrome identified by gene expression analysis . Cancer Res . 2004;64:5578–5586
  15. Tracey L , Villuendas R , Dotor AM , et al.   Mycosis fungoides shows concurrent deregulation of multiple genes involved in the TNF signaling pathway (An expression profile study) . Blood . 2003;102:1042–1050
  16. Mao X , Orchard G , Lillington DM , et al.   Amplification and overexpression of JUNB is associated with primary cutaneous T-cell lymphomas . Blood . 2003;101:1513–1519
  17. Yu H , Jove R . The STATS of cancer – New molecular targets come of age . Nat Rev Cancer . 2004;4:97–105
  18. Zhang Q , Nowak I , Vonderheid EC , et al.   Activation of Jak/STAT proteins involved in signal transduction pathway mediated by receptor for interleukin 2 in malignant T lymphocytes derived from cutaneous anaplastic large T-cell lymphoma and Sezary syndrome . Proc Natl Acad Sci U S A . 1996;93:9148–9153
  19. Tracey L , Villuendas R , Ortiz P , et al.   Identification of genes involved in resistance to interferon-α in cutaneous T-cell lymphoma . Am J Pathol . 2002;161:1825–1837
  20. Mitchell TJ , Whittaker SJ , John S . Dysregulated expression of COOH-terminally truncated Stat5 and loss of IL2-inducible Stat5-dependent gene expression in Sezary Syndrome . Cancer Res . 2003;63:9048–9054

 This supplement was supported by an unrestricted educational grant from Zeneus Pharma Ltd.

 Dr Whittaker has served as a consultant to Zeneus, Genmab, and Ligand.

PII: S0093-7754(05)00509-9

doi: 10.1053/j.seminoncol.2005.12.015

Seminars in Oncology
Volume 33 , Pages 3-6 , February 2006

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