Seminars in Oncology
Volume 33 , Pages 33-36 , February 2006

Future Perspectives in the Treatment of Cutaneous T-Cell Lymphoma (CTCL)

  • Reinhard Dummer

      Affiliations

    • Corresponding Author InformationAddress correspondence and reprint requests to Reinhard Dummer, MD, Department of Dermatology, University Hospital of Zurich, Gloriastrasse 31, CH−8091 Zürich

References 

  1. Dummer R , Willers J , Kamarashev J , et al.   Pathogenesis of cutaneous lymphomas . Semin Cutan Med Surg . 2000;19:78–86
  2. Dummer R , Heald PW , Nestle FO , et al.   Sézary Syndrome’s T-cell clones display T helper 2 cytokines and express the accessory factor-1 (interferon gamma receptor beta chain) . Blood . 1996;88:1383–1389
  3. Rook AH , Gottlieb SL , Wolfe JT , et al.   Pathogenesis of cutaneous T-cell lymphoma – Implications for the use of recombinant cytokines and photopheresis . Clin Exp Immunol . 1997;107:16–20 (suppl 1)
  4. Rook AH , Zaki MH , Wysocka M , et al.   The role for interleukin-12 therapy of cutaneous T cell lymphoma . Ann N Y Acad Sci . 2001;941:177–184
  5. Motzer RJ , Rakhit A , Thompson J , et al.   Phase II trial of branched peginterferon-alpha 2a (40 kDa) for patients with advanced renal cell carcinoma . Ann Oncol . 2002;13:1799–1805
  6. Dummer R , Urosevic M , Kempf W , et al.   Imiquimod induces complete clearance of a PUVA-resistant plaque in mycosis fungoides . Dermatology . 2003;207:116–118
  7. Gilliet M , Conrad C , Geiges M , et al.   Psoriasis triggered by toll-like receptor 7 agonist imiquimod in the presence of dermal plasmacytoid dendritic cell precursors . Arch Dermatol . 2004;140:1490–1495
  8. Ling P , Gately MK , Gubler U , et al.   Human IL-12 p40 homodimer binds to the IL-12 receptor but does not mediate biologic activity . J Immunol . 1995;154:116–127
  9. Rook AH , Kubin M , Cassin M , et al.   IL-12 reverses cytokine and immune abnormalities in Sezary syndrome . J Immunol . 1995;154:1491–1498
  10. Rook AH , Wood GS , Yoo EK , et al.   Interleukin-12 therapy of cutaneous T-cell lymphoma induces lesion regression and cytotoxic T-cell responses . Blood . 1999;94:902–908
  11. Dummer R , Hassel JC , Fellenberg F , et al.   Adenovirus-mediated intralesional interferon-gamma gene transfer induces tumor regressions in cutaneous lymphomas . Blood . 2004;104:1631–1638
  12. Zhang C , Hazarika P , Ni X , et al.   Induction of apoptosis by bexarotene in cutaneous T-cell lymphoma cells (Relevance to mechanism of therapeutic action) . Clin Cancer Res . 2002;8:1234–1240
  13. Zhang C , Duvic M . Retinoids (Therapeutic applications and mechanisms of action in cutaneous T-cell lymphoma) . Dermatol Ther . 2003;16:322–330
  14. Dummer R , Döbbeling U , Geertsen R , et al.   Interferon resistance of cutaneous T-cell lymphoma-derived clonal T-helper 2 cells allows selective viral replication . Blood . 2001;97:523–527
  15. Foss FM , Borkowski TA , Gilliom M , et al.   Chimeric fusion protein toxin DAB486IL-2 in advanced mycosis fungoides and the Sezary syndrome (Correlation of activity and interleukin-2 receptor expression in a phase II study) . Blood . 1994;84:1765–1774
  16. Olsen E , Duvic M , Frankel A , et al.   Pivotal phase III trial of two dose levels of denileukin diftitox for the treatment of cutaneous T-cell lymphoma . J Clin Oncol . 2001;19:376–388
  17. Qin JZ , Kamarashev J , Zhang CL , et al.   Constitutive and interleukin-7- and interleukin-15-stimulated DNA binding of STAT and novel factors in cutaneous T cell lymphoma cells . J Invest Dermatol . 2001;117:583–589
  18. Bayes M , Rabasseda X , Prous JR , et al.   Gateways for clinical trials . Methods Find Exp Clin Pharmacol . 2004;26:357–391
  19. Dummer R . Emerging drugs in cutaneous T-cell lymphomas . Expert Opin Emerg Drugs . 2005;10:381–392

 This supplement was supported by an unrestricted educational grant from Zeneus Pharma Ltd.

 Prof Dummer has participated in scientific symposia and advisory boards sponsored by Zeneus and Ligand Pharma.

PII: S0093-7754(05)00515-4

doi: 10.1053/j.seminoncol.2005.12.021

Seminars in Oncology
Volume 33 , Pages 33-36 , February 2006

Article Tools

* Image Usage & Resolution