Seminars in Oncology
Volume 33, Issue 2 , Pages 167-173 , April 2006

Genomics of Chronic Lymphocytic Leukemia MicroRNAs as New Players With Clinical Significance

  • George Adrian Calin
    • ,
  • Carlo Maria Croce

      Affiliations

    • Corresponding Author InformationAddress correspondence to Dr Carlo M. Croce, Ohio State University, Comprehensive Cancer Center, Wiseman Hall Room 385K, 400 12th Ave, Columbus Ohio, OH 43210.

References 

  1. Bartel DP . MicroRNAs (Genomics, biogenesis, mechanism, and function) . Cell . 2004;116:281–297
  2. Ambros V . MicroRNA pathways in flies and worms (Growth, death, fat, stress, and timing) . Cell . 2003;113:673–676
  3. Bentwich I , Avniel A , Karov Y , et al.   Identification of hundreds of conserved and nonconserved human microRNAs . Nat Genet . 2005;37:766–770
  4. Pekarsky Y , Zanesi N , Aqeilan R , et al.   Tcl1 as a model for lymphomagenesis . Hematol Oncol Clin North Am . 2004;18:863–879
  5. Virgilio L , Lazzeri C , Bichi R , et al.   Deregulated expression of TCL1 causes T cell leukemia in mice . Proc Natl Acad Sci U S A . 1998;95:3885–3889
  6. Bichi R , Shinton SA , Martin ES , et al.   Human chronic lymphocytic leukemia modeled in mouse by targeted TCL1 expression . Proc Natl Acad Sci U S A . 2003;99:6955–6960
  7. Gumy-Pause F , Wacker P , Sappino AP . ATM gene and lymphoid malignancies . Leukemia . 2004;18:238–242
  8. Stankovic T , Weber P , Stewart G , et al.   Inactivation of ataxia telangiectasia mutated gene in B-cell chronic lymphocytic leukaemia . Lancet . 1999;353:26–29
  9. Bullrich F , Rasio D , Kitada S , et al.   ATM mutations in B-cell chronic lymphocytic leukemia . Cancer Res . 1999;59:24–27
  10. Pekarsky Y , Hallas C , Croce CM . Molecular basis of mature T-cell leukemia . JAMA . 2001;286:2308–2314
  11. Pekarsky Y , Calin GA , Ageilan R , et al.   Chronic lymphocytic leukemia (Molecular genetics and animal models) . Curr Top Microbiol Immunol . 2005;294:51–70
  12. Dong JT , Boyd JC , Frierson HFJ . Loss of heterozygosity at 13q14.3 and 13q21 in high grade, high stage prostate cancer . Prostate . 2001;49:166–171
  13. Calin GA , Trapasso F , Shimizu M , et al.   Familial cancer associated with a polymorphism in ARLTS1 . N Engl J Med . 2005;352:1667–1676
  14. Migliazza A , Bosch F , Komatsu H , et al.   Nucleotide sequence, transcription map, and mutation analysis of the 13q14.3 chromosomal region deleted in B-cell chronic lymphocytic leukemia . Blood . 2001;97: 2198–2104
  15. Bullrich F , Fujii H , Calin GA , et al.   Characterization of the 13q14.3 tumor suppressor locus in CLL (identification of ALT1, an alternative splice variant of the LEU2 gene) . Cancer Res . 2001;61:6640–6648
  16. Calin GA , Dumitru CD , Shimizu M , et al.   Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14.3 in chronic lymphocytic leukemia . Proc Natl Acad Sc U S A . 2002;99:15524–15529
  17. Liu Y , Corcoran M , Rasool O , et al.   Cloning of two candidate tumor suppressor genes within a 10 kb region on chromosome 13q14.3, frequently deleted in chronic lymphocytic leukemia . Oncogene . 1997;15:2463–2473
  18. Storz G , Altuvia S , Wassarman KM . An abundance of RNA regulators . Annu Rev Biochem . 2005;74:199–217
  19. Moss EG . MicroRNA . In:  Barciszewski J ,  Erdman VA editor. Noncoding RNAs (Molecular Biology and Molecular Medicine) . 2003;p. 98–114 Eurekah.com
  20. Ke X-S , Liu C-M , Liu D-P , et al.   Micro-RNAs (Key participants in gene regulatory networks) . Curr Opin Chem Biol . 2003;7:516–523
  21. Pasquinelli AE , Reinhart BJ , Slack F , et al.   Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA . Nature . 2000;408:86–89
  22. Baskerville S , Bartel DP . Microarray profiling of microRNAs reveals frequent coexpression with neighboring miRNAs and host genes . RNA . 2005;11:241–247
  23. Xu P , Vernooy SY , Guo M , et al.   The Drosophila microRNA Mir-14 suppresses cell death and is required for normal fat metabolism . Curr Biol . 2003;13:790–795
  24. Brennecke J , Hipfner DR , Stark A , et al.   bantam encodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapoptotic gene hid in Drosophila . Cell . 2003;113:25–36
  25. Pasquinelli AE . MicroRNAs (Deviants no longer) . Trends Genet . 2002;18:171–173
  26. Lai EC . MicroRNAs are complementary to 3′ UTR sequence motifs that mediate negative post-translational regulation . Nature Genet . 2002;30:363–364
  27. Lim LP , Lau NC , Garrett-Engele P , et al.   Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs . Nature . 2005;433:769–773
  28. Calin GA , Sevignani C , Dumitru CD , et al.   Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers . Proc Natl Acad Sci U S A . 2004;101:2999–3004
  29. Liu C-G , Calin GA , Meloon B , et al.   An oligonucleotide microchip for genome-wide miRNA profiling in human and mouse tissues . Proc Natl Acad Sci U S A . 2004;101:9740–9744
  30. Chen CZ , Li L , Lodish HF , et al.   MicroRNAs modulate hematopoietic lineage differentiation . Science . 2004;303:83–86
  31. Kluiver J , Poppema S , de Jong D , et al.   BIC and miR-155 are highly expressed in Hodgkin, primary mediastinal and diffuse large B cell lymphomas . J Pathol . 2005;207:243–249
  32. Eis PS , Tam W , Sun L , et al.   Accumulation of miR-155 and BIC RNA in human B cell lymphomas . Proc Natl Acad Sci U S A . 2005;102:3627–3632
  33. He L , Thomson JM , Hemann MT , et al.   A microRNA polycistron as a potential human oncogene . Nature . 2005;435:828–833
  34. Rassenti LZ , Huynh L , Toy TL , et al.   ZAP-70 compared with immunoglobulin heavy-chain gene mutation status as a predictor of disease progression in chronic lymphocytic leukemia . N Engl J Med . 2004;351:893–901
  35. Crespo M , Bosch F , Villamor N , et al.   ZAP-70 expression as a surrogate for immunoglobulin-variable-region mutations in chronic lymphocytic leukemia . N Engl J Med . 2003;348:1764–1775
  36. Chiorazzi N , Rai KR , Ferrarini M . Chronic lymphocytic leukemia . N Engl J Med . 2005;352:804–815
  37. Dohner H , Stilgenbaue S , Benner A , et al.   Genomic aberrations and survival in chronic lymphocytic leukemia . N Engl J Med . 2000;343:1910–1916
  38. Kipps TJ . Chronic lymphocytic leukemia and related diseases . In:  Beutler E ,  Lichtman MA ,  Coller BS , et al. editor. Williams Hematology . New York, NY: McGraw-Hill; 2001;p. 1163–1194
  39. Goldin LR , Ishibe N , Sgambati MT , et al.   A genome scan of 18 families with chronic lymphocytic leukaemia . Br J Haematol . 2003;121:866–873
  40. Segel GB , Lichtman MA . Familial (inherited) leukemia, lymphoma, and myeloma (An overview) . Blood Cells Mol Dis . 2004;32:246–261
  41. Houlston RS , Sellick G , Yuille M , et al.   Causation of chronic lymphocytic leukemia--insights from familial disease . Leuk Res . 2003;27:871–876
  42. Calin GA , Ferracin M , Cimmino A , et al.   A unique microRNA signature associated with prognostic factors and disease progression in B cell chronic lymphocytic leukemia . N Engl J Med . 2005;353:1793–1801
  43. McManus MT . MicroRNAs and cancer . Semin Cancer Biol . 2003;13:253–258
  44. Lu J , Getz G , Miska EA , et al.   MicroRNA expression profiles classify human cancers . Nature . 2005;435:834–838
  45. Iway N , Naraba H . Polymorphisms in human pre-miRNAs . Biochem Biophys Res Commun . 2005;331:1439–1444
  46. Catovsky D . Definition and diagnosis of sporadic and familial chronic lymphocytic leukemia . Hematol Oncol Clin North Am . 2004;18:783–794
  47. Cory S , Adams JM . The BCL2 family (Regulators of the cellular life-or-death switch) . Nat Rev . 2002;2:647–656
  48. Sanchez-Beato M , Sanchez-Aguilera A , Piris MA . Cell cycle deregulation in B-cell lymphomas . Blood . 2003;101:1220–1235
  49. Tsujimoto Y , Cossman J , Jaffe E , et al.   Involvement of bcl-2 gene in human follicular lymphoma . Science . 1985;228:1440–1443
  50. Tsujimoto Y , Finger LR , Yunis J , et al.   Cloning of the chromosome breakpoint of neoplastic B cells with the t(14;18) chromosome translocation . Science . 1984;226:1097–1099
  51. Kitada S , Andersen J , Akar S , et al.   Expression of apoptosis-regulating proteins in chronic lymphocytic leukemia (Correlations with in vitro and in vivo chemoresponses) . Blood . 1998;91:3379–3389
  52. Adachi M , Tefferi A , Greipp PR , et al.   Preferential linkage of bcl-2 to immunoglobulin light chain gene in chronic lymphocytic leukemia . J Exp Med . 1990;171:559–564
  53. Cimminoi A , Calin GA , Fabbri M , et al.   miR-15 and miR-16 induce apoptosis by targeting BCL2 . Proc Natl Acad Sci U S A . 2005;102:13944–13949
  54. Calin GA , Liu CG , Sevignani C , et al.   MicroRNA profiling reveals distinct signatures in B cell chronic lymphocytic leukemias . Proc Natl Acad Sci U S A . 2004;101:11755–11760

 The research in Dr Croce’s lab is supported by Program Project Grants No. P01CA76259 and P01CA81534 from the National Cancer Institute; Dr Calin is a Kimmel Foundation Scholar.

PII: S0093-7754(06)00019-4

doi: 10.1053/j.seminoncol.2006.01.010

Seminars in Oncology
Volume 33, Issue 2 , Pages 167-173 , April 2006

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