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Seminars in Oncology
Volume 33, Issue 2
, Pages 186-194
, April 2006
Risk Stratification in Chronic Lymphocytic Leukemia
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CLL subgroups carrying genetic high-risk features such as 11q-, 17p-, or V3-21 usage show a high rate of discorant VH and ZAP-70 status
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VH mutation status and genomic aberrations in the prospective CLL1 trial (Binet A) of the German CLL Study Group (GCLLSG)
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Elevated thymidine kinase and short lymphocyte doubling time in combination with unfavourable cytogenetics or unmutated IgVH status are strong predictors for high individual risk for rapid disease progression in patients with B-CLL in Binet A stage
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Additional genetic high-risk features such as 11q deletion, 17p deletion, and V3-21 usage characterize discordance of ZAP-70 and VH mutation status in chronic lymphocytic leukemia
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Jan 27 [Epub ahead of print]
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11q deletions identify a new subset of B-cell chronic lymphocytic leukemia characterized by extensive nodal involvement and inferior prognosis
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Expression of unmutated VH genes is a detrimental prognostic factor in chronic lymphocytic leukemia. Predictive value of mutational IgVH gene status for incomplete response and relapse after oral fludarabine phosphate (fludara oral) and cyclophosphamide in previously untreated CLL patients
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Supported by Wilhelm Sander-Stiftung (2003.086.1, 2001.004.2), Deutsche Krebshilfe (106116, 70-3173-Tr 3 B4), Fresenius Stiftung (CLL4VH), Amgen, Roche, and Schering.
PII: S0093-7754(06)00026-1
doi: 10.1053/j.seminoncol.2006.01.017
© 2006 Elsevier Inc. All rights reserved.
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Seminars in Oncology
Volume 33, Issue 2
, Pages 186-194
, April 2006
