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Seminars in Oncology
Volume 33
, Pages 15-18
, June 2006
Protein Kinase C-β as a Therapeutic Target in Breast Cancer
References
-
.
Protein kinase C in disease
.
In:
Newton AC
editors.
Methods in Molecular Biology, vol 233
(Protein kinase C protocols)
. Totowa, NJ: Humana Press Inc; 2003;p. 519–537
-
.
Protein kinase C inhibitors as novel anticancer drugs
.
Expert Opin Invest Drugs
. 2001;10:2117–2140
- . Protein kinase C isozymes as potential targets for anticancer therapy . Curr Cancer Drug Targets . 2004;4:125–146
- . The molecular heterogeneity of protein kinase C and its implications for cellular regulation . Nature . 1988;334:661–665
-
.
Protein kinase C isoenzymes
(Divergence in signal transduction?)
.
Biochem J
. 1993;291:329–343
-
Protein kinase C isotypes in human erythroleukemia cell proliferation and differentiation
.
J Cell Sci
. 1992;101:671–679
- Protein kinase C isotypes in human erythroleukemia (K562) cell proliferation and differentiation (Evidence that βII protein kinase C is required for proliferation) . J Biol Chem . 1993;268:15847–15853
- Expression and properties of two types of protein kinase C (Alternative splicing from a single gene) . Science . 1987;236:1116–1120
- Overexpression of protein kinase C βII induces colonic hyperproliferation and increased sensitivity to colon carcinogenesis . J Cell Biol . 1999;145:699–711
- . Protein kinase C isozymes in colon carcinogenesis (Guilt by omission) . Gastroenterology . 2001;120:1868–1872
- Elevated protein kinase C beta II is an early promotive event in colon carcinogenesis . Cancer Res . 2001;61:1375–1381
- Protein kinase C (PKC) βII induces cell invasion through a Ras/Mek-, PKCiota/Rac 1-dependent signaling pathway . J Biol Chem . 2004;279:22118–22123
- Down-regulation of protein kinase C alpha detected in human colorectal cancer . Biochem Mol Biol Int . 1998;44:523–528
- Morphodensitometric analysis of protein kinase C beta (II) expression in rat colon (Modulation by diet and relation to in situ cell proliferation and apoptosis) . Carcinogenesis . 2000;21:1513–1519
- Adenoma-specific alterations of protein kinase C expression in Apc(MIN) mice . Cancer Res . 2000;60:2077–2080
- Diffuse large B-cell lymphoma outcome prediction by gene-expression profiling and supervised machine learning . Nat Med . 2002;8:68–74
- Targeting protein kinase C (New therapeutic opportunities against high-grade malignant gliomas?) . Oncologist . 2002;7:17–33
- PKC-beta controls I kappa B kinase lipid raft recruitment and activation in response to BCR signaling . Nat Immunol . 2002;3:780–786
- Elevated protein kinase C expression in human breast tumor biopsies relative to normal breast tissue . Cancer Res . 1989;49:3215–3217
- Elevation of protein kinase A and protein kinase C activities in malignant as compared with normal human breast tissue . Eur J Cancer . 1996;32A:2120–2126
- Immunological quantitation of phospholipid/Ca2+-dependent protein kinase of human mammary carcinoma cells (Inverse relationship to estrogen receptors) . Int J Cancer . 1987;40:344–348
- . Elevated level of nuclear protein kinase C in multidrug-resistant MCF-7 human breast carcinoma cells . Cancer Res . 1992;52:3750–3759
- Increased protein kinase Cδ in mammary tumor cells (relationship to transformation and metastasic progression) . Oncogene . 1999;18:6748–6757
- Protein Kinase Cδ involvement in mammary tumor cell metastasis . Cancer Res . 1999;59:3230–3238
- Protein kinase C alpha expression in breast and ovarian cancer . Oncology . 2004;67:1–10
- MCF-7 breast cancer cells transfected with protein kinase C-alpha exhibit altered expression of other protein kinase C isoforms and display a more aggressive neoplastic phenotype . J Clin Invest . 1995;95:1906–1915
- . Protein kinase C and its isoforms in human breast cancer cells (Relationship to the invasive phenotype) . Int J Oncol . 1998;12:1349–1354
- Induction of a less aggressive breast cancer phenotype by protein kinase C-α and β-overexpression . Cell Growth Differ . 1996;7:1187–1198
- Upregulation of PKCδ contributes to antiestrogen resistance in mammary tumor cells . Oncogene . 2005;24:3166–3176
- Regulation of alternative splicing of protein kinase C beta by insulin . J Biol Chem . 1995;270:13326–13332
- Characterization of vascular endothelial growth factor’s effect on the activation of protein kinase C, its isoforms, and endothelial cell growth . J Clin Invest . 1996;98:2018–2026
- . VEGF activates protein kinase C-dependent, but Ras independent Raf-MEK-MAP kinase pathway for DNA synthesis in primary endothelial cells . Oncogene . 1999;18:2221–2230
-
.
VEGF signaling
(integration and multi-tasking in endothelial cell biology)
.
Biochem Soc Trans
. 2003;6:1171–1177
- Protein kinase C lies on the signaling pathway for vascular endothelial growth factor-mediated tumor development and angiogenesis . Cancer Res . 1999;59:4413–4418
-
E2100
(A randomized phase III trial of paclitaxel versus paclitaxel plus bevacizumab as first-line therapy for locally recurrent or metastatic breast cancer)
. Orlando, FL: Presented at the 41st Annual Meeting of the American Society of Clinical Oncology; 2004;
May 13-17
- The protein kinase cb-selective inhibitor, enzastaurin (LY317615.HCL), supressess signaling through the Akt pathway, induces apoptosis, and suppresses growth of human colon cancer and glioblastoma xenografts . Cancer Res . 2005;65:7462–7469
- Antiangiogenic effects of a protein kinase Cβ-selective small molecule . Cancer Chemother Pharmacol . 2002;49:69–77
- LY317615 decreases plasma VEGF levels in human tumor xenograft-bearing mice . Cancer Chemother Pharmacol . 2004;53:133–140
- Antiangiogenic and antitumor effects of a protein kinase C beta inhibitor in human breast cancer and ovarian cancer xenografts . Invest New Drugs . 2002;20:241–251
-
Phase 1 study of LY317615, a protein kinase Cb inhibitor
.
Proc Am Soc Clin Oncol
. 2002;21:326;
abstr
-
.
Phase I and pharmacologic study of enzastaurin HCl, gemcitabine and cisplatin
.
Proc Am Soc Clin Oncol
. 2004;24:3129;
abstr
-
Results from phase II trial of enzastaurin (LY317615) in patients with recurrent high grade gliomas
.
Proc Am Soc Clin Oncol
. 2005;23:1504;
abstr
-
A phase II study of enzastaurin, a protein kinase C-β (PKCβ) inhibitor, in the treatment of relapsed diffuse large B-cell lymphoma (DLBCL)
.
Blood
. 2005;106:934;
abstr
Dr Sledge’s work is supported in part by a grant from the Breast Cancer Research Foundation and the Walther Medical Foundation.
PII: S0093-7754(06)00139-4
doi: 10.1053/j.seminoncol.2006.03.019
© 2006 Elsevier Inc. All rights reserved.
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Seminars in Oncology
Volume 33
, Pages 15-18
, June 2006
