Seminars in Oncology
Volume 33 , Pages 19-23 , June 2006

Overview of Gemcitabine Activity in Advanced Breast Cancer

  • Ian E. Smith

      Affiliations

    • Corresponding Author InformationAddress reprint requests to Prof Ian E. Smith, Breast Unit, Royal Marsden Hospital, Fulham Road, London SW3 6JJ, UK.

References 

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  2. Blackstein M , Vogel CL , Ambinder R , et al.   Gemcitabine as first-line therapy in patients with metastatic breast cancer (A phase II trial) . Oncology . 2002;62:2–8
  3. Spielmann M , Llombart-Cussac A , Kalla S , et al.   Single-agent gemcitabine is active in previously treated metastatic breast cancer . Oncology . 2001;60:303–307
  4. Albain KS , Nag S , Calderillo-Ruiz G , et al.   Global phase III study of gemcitabine plus paclitaxel (GT) vs. paclitaxel (T) as frontline therapy for metastatic breast cancer (MBC) (First report of overall survival) . J Clin Oncol . 2004;22:5s; abstr 510
  5. Fountzilas G , Nicolaides C , Bafaloukos D , et al.   Docetaxel and gemcitabine in anthracycline-resistant advanced breast cancer (A Hellenic Cooperative Oncology Group Phase II study) . Cancer Invest . 2000;18:503–509
  6. Mavroudis D , Malamos N , Alexopoulos A , et al.  Greek Breast Cancer Cooperative Group   Salvage chemotherapy in anthracycline-pretreated metastatic breast cancer patients with docetaxel and gemcitabine (A multicenter phase II trial) . Ann Oncol . 1999;10:211–215
  7. Laufman LR , Spiridonidis CH , Pritchard J , et al.   Monthly docetaxel and weekly gemcitabine in metastatic breast cancer (A phase II trial) . Ann Oncol . 2001;12:1259–1264
  8. Brandi M , Giotta F , Vici P , et al.   Salvage chemotherapy with docetaxel (TXT) and gemcitabine (GEM) in metastatic breast cancer (MBC) (Preliminary results of a multicenter phase II trial of GOIM (Gruppo Oncologico dell’Italia Merdidionale)) . Proc Am Soc Clin Oncol . 2001;20:52b; abstr 1956
  9. Kornek GV , Haider K , Kwasny W , et al.   Treatment of advanced breast cancer with docetaxel and gemcitabine with and without human granulocyte colony-stimulating factor . Clin Cancer Res . 2002;8:1051–1056
  10. Pelegri A , Calvo L , Mayordomo JI , et al.   Gemcitabine plus docetaxel administered every other week as first-line treatment of metastatic breast cancer (Preliminary results from a phase II trial) . Semin Oncol . 2004;31(suppl 5):20–24
  11. Chan S , Romieu G , Huober J , et al.   Gemcitabine plus docetaxel (GD) versus capecitabine plus docetaxel (CD) for anthracycline-pretreated metastatic breast cancer (MBC) patients (pts) (Results of a European phase III study) . J Clin Oncol . 2005;23(suppl 16):581; abstr
  12. Colomer R , Llombart A , Lluch A , et al.   Paclitaxel/gemcitabine administered every two weeks in advanced breast cancer (Preliminary results of a phase II trial) . Semin Oncol . 2000;27(suppl 2):20–24
  13. Sledge GW . Gemcitabine combined with paclitaxel or paclitaxel/trastuzumab in metastatic breast cancer . Semin Oncol . 2003;30:19–21
  14. Conte P , Salvadori B , Donati S , et al.   The gemcitabine/epirubicin/paclitaxel trials in advanced breast cancer . Oncology . 2001;15:41–43
  15. Sanchez-Rovira P , Jaen A , Gonzalez E , et al.   Biweekly gemcitabine, doxorubicin, and paclitaxel as first-line treatment in metastatic breast cancer (Final results from a phase II trial) . Oncology . 2001;15:44–47
  16. Zielinski C , Beslija S , Mrsic-Krmpotic Z , et al.   Gemcitabine, epirubicin, and paclitaxel versus fluorouracil, epirubicin, and cyclophosphamide as first-line chemotherapy in metastatic breast cancer (A Central European Cooperative Oncology Group International, multicenter, prospective, randomized phase III trial) . J Clin Oncol . 2005;23:1401–1408

 Dr Smith has received honoraria from Eli Lilly and Company.

PII: S0093-7754(06)00141-2

doi: 10.1053/j.seminoncol.2006.03.020

Seminars in Oncology
Volume 33 , Pages 19-23 , June 2006

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