Seminars in Oncology
Volume 33 , Pages 2-7 , June 2006

Pathogenesis of Cardiotoxicity Induced by Anthracyclines

  • Perry Elliott

      Affiliations

    • Corresponding Author InformationAddress reprint requests to Perry Elliott, MD, The Heart Hospital, University College London Hospitals, 16–18 Westmoreland St, W1G 8PH London, UK.

References 

  1. Orditura M , Quaglia F , Morgillo F , et al.  Pegylated liposomal doxorubicin (Pharmacologic and clinical evidence of potent antitumor activity with reduced anthracycline-induced cardiotoxicity (review)) . Oncol Rep . 2004;12:549–556
  2. Minotti G , Menna P , Salvatorelli E , et al.  Anthracyclines (Molecular advances and pharmacologic developments in antitumor activity and cardiotoxicity) . Pharmacol Rev . 2004;56:185–229
  3. Andrieu-Abadie N . [Cardiotoxicity of anthracyclines (mechanisms and pharmacologic targets for prevention]) . Therapie . 2004;59:121–126
  4. Tan C , Tasaka H , Yu KP , et al.  Daunomycin, an antitumor antibiotic, in the treatment of neoplastic disease. Clinical evaluation with special reference to childhood leukemia . Cancer . 1967;20:333–353
  5. Swain SM , Whaley FS , Ewer MS . Congestive heart failure in patients treated with doxorubicin (A retrospective analysis of three trials) . Cancer . 2003;97:2869–2879
  6. Von Hoff DD , Layard MW , Basa P , et al.  Risk factors for doxorubicin-induced congestive heart failure . Ann Intern Med . 1979;91:710–717
  7. Stevenson LW . Tailored therapy to hemodynamic goals for advanced heart failure . Eur J Heart Fail . 1999;1:251–257
  8. Jensen BV , Skovsgaard T , Nielsen SL . Functional monitoring of anthracycline cardiotoxicity (A prospective, blinded, long-term observational study of outcome in 120 patients) . Ann Oncol . 2002;13:699–709
  9. Catimel G , Spielmann M , Dieras V , et al.   Phase I study of paclitaxel and epirubicin in patients with metastatic breast cancer (A preliminary report on safety). Semin Oncol. 1996;23(suppl 1):24–27
  10. Limat S , Demesmay K , Voillat L , et al.  Early cardiotoxicity of the CHOP regimen in aggressive non-Hodgkin’s lymphoma . Ann Oncol . 2003;14:277–281
  11. Ryberg M , Nielsen D , Skovsgaard T , et al.  Epirubicin cardiotoxicity (An analysis of 469 patients with metastatic breast cancer) . J Clin Oncol . 1998;16:3502–3508
  12. Haq MM , Legha SS , Choksi J , et al.  Doxorubicin-induced congestive heart failure in adults . Cancer . 1985;56:1361–1365
  13. Krischer JP , Epstein S , Cuthbertson DD , et al.  Clinical cardiotoxicity following anthracycline treatment for childhood cancer (The Pediatric Oncology Group experience) . J Clin Oncol . 1997;15:1544–1552
  14. Lipshultz SE , Colan SD , Gelber RD , et al.  Late cardiac effects of doxorubicin therapy for acute lymphoblastic leukemia in childhood . N Engl J Med . 1991;324:808–815
  15. Shan K , Lincoff AM , Young JB . Anthracycline-induced cardiotoxicity . Ann Intern Med . 1996;125:47–58
  16. Lipshultz SE , Lipsitz SR , Sallan SE , et al.  Chronic progressive cardiac dysfunction years after doxorubicin therapy for childhood acute lymphoblastic leukemia . J Clin Oncol . 2005;23:2629–2636
  17. Zambetti M , Moliterni A , Materazzo C , et al.  Long-term cardiac sequelae in operable breast cancer patients given adjuvant chemotherapy with or without doxorubicin and breast irradiation . J Clin Oncol . 2001;19:37–43
  18. Meinardi MT , van Veldhuisen DJ , Gietema JA , et al.  Prospective evaluation of early cardiac damage induced by epirubicin-containing adjuvant chemotherapy and locoregional radiotherapy in breast cancer patients . J Clin Oncol . 2001;19:2746–2753
  19. Praga C , Beretta G , Vigo PL , et al.  Adriamycin cardiotoxicity (A survey of 1273 patients) . Cancer Treat Rep . 1979;63:827–834
  20. Li T , Singal PK . Adriamycin-induced early changes in myocardial antioxidant enzymes and their modulation by probucol . Circulation . 2000;102:2105–2110
  21. Arola OJ , Saraste A , Pulkki K , et al.  Acute doxorubicin cardiotoxicity involves cardiomyocyte apoptosis . Cancer Res . 2000;60:1789–1792
  22. Childs AC , Phaneuf SL , Dirks AJ , et al.  Doxorubicin treatment in vivo causes cytochrome C release and cardiomyocyte apoptosis, as well as increased mitochondrial efficiency, superoxide dismutase activity, and Bcl-2:Bax ratio . Cancer Res . 2002;62:4592–4598
  23. Kremer LC , van Dalen EC , Offringa M , et al.  Anthracycline-induced clinical heart failure in a cohort of 607 children (Long-term follow-up study) . J Clin Oncol . 2001;19:191–196
  24. Steinherz LJ , Steinherz PG , Tan CT , et al.  Cardiac toxicity 4 to 20 years after completing anthracycline therapy . JAMA . 1991;266:1672–1677
  25. Haddy TB , Adde MA , McCalla J , et al.  Late effects in long-term survivors of high-grade non-Hodgkin’s lymphomas . J Clin Oncol . 1998;16:2070–2079
  26. Ewer MS , Ali MK , Mackay B , et al.  A comparison of cardiac biopsy grades and ejection fraction estimations in patients receiving Adriamycin . J Clin Oncol . 1984;2:112–117
  27. Larsen RL , Jakacki RI , Vetter VL , et al.  Electrocardiographic changes and arrhythmias after cancer therapy in children and young adults . Am J Cardiol . 1992;70:73–77
  28. Billingham ME , Mason JW , Bristow MR , et al.  Anthracycline cardiomyopathy monitored by morphologic changes . Cancer Treat Rep . 1978;62:865–872
  29. Panteghini M . Role and importance of biochemical markers in clinical cardiology . Eur Heart J . 2004;25:1187–1196
  30. Antman EM . Decision making with cardiac troponin tests . N Engl J Med . 2002;346:2079–2082
  31. Cardinale D , Sandri MT , Martinoni A , et al.  Myocardial injury revealed by plasma troponin I in breast cancer treated with high-dose chemotherapy . Ann Oncol . 2002;13:710–715
  32. Auner HW , Tinchon C , Linkesch W , et al.  Prolonged monitoring of troponin T for the detection of anthracycline cardiotoxicity in adults with hematological malignancies . Ann Hematol . 2003;82:218–222
  33. Lipshultz SE , Rifai N , Sallan SE , et al.  Predictive value of cardiac troponin T in pediatric patients at risk for myocardial injury . Circulation . 1997;96:2641–2648
  34. Thomas X , Le QH , Fiere D . Anthracycline-related toxicity requiring cardiac transplantation in long-term disease-free survivors with acute promyelocytic leukemia . Ann Hematol . 2002;81:504–507

PII: S0093-7754(06)00208-9

doi: 10.1053/j.seminoncol.2006.04.020

Seminars in Oncology
Volume 33 , Pages 2-7 , June 2006