« Previous
Next »
Seminars in Oncology
Volume 33, Issue 5
, Pages 607-613
, October 2006
Mammalian Target of Rapamycin Inhibitors in Renal Cell Carcinoma: Current Status and Future Applications
References
- Cancer statistics, 2006. CA Cancer J Clin. 2006;56:106–130
- . Opportunities and challenges in the development of kinase inhibitor therapy for cancer. Genes Dev. 2003;17:2998–3010
- Randomized phase II study of multiple dose levels of CCI-779, a novel mammalian target of rapamycin kinase inhibitor, in patients with advanced refractory renal cell carcinoma. J Clin Oncol. 2004;22:909–918
- . The phosphatidylinositol 3-kinase AKT pathway in human cancer. Nat Rev Cancer. 2002;2:489–501
- . Mammalian target of rapamycin: Immunosuppressive drugs uncover a novel pathway of cytokine receptor signaling. Curr Opin Immunol. 1998;10:330–336
- Studies on the mechanism of resistance to rapamycin in human cancer cells. Mol Pharmacol. 1998;54:815–824
- Rapamycin causes poorly reversible inhibition of mTOR and induces p53-independent apoptosis in human rhabdomyosarcoma cells. Cancer Res. 1999;59:886–894
- Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins. Nat Cell Biol. 2003;5:578–581
- TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat Cell Biol. 2002;4:648–657
- . mTOR and cancer: Reason for dancing at the crossroads?. Curr Opin Genet Dev. 2006;16:78–84
- . The TOR pathway: A target for cancer therapy. Nat Rev Cancer. 2004;4:335–348
- . Will mTOR inhibitors make it as cancer drugs?. Cancer Cell. 2003;4:343–348
- Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy. Nature. 2004;428:332–337
- . Tumour anoxia and the response to radiation. Sci Basis Med Annu Rev. 1965;74–90
- The concentration of oxygen dissolved in tissues at the time of irradiation as a factor in radiotherapy. Br J Radiol. 1953;26:638–648
- . Blood supply, oxygenation status and metabolic micromilieu of breast cancers: Characterization and therapeutic relevance. Int J Oncol. 2000;17:869–879
- . Hypoxia—A key regulatory factor in tumour growth. Nat Rev Cancer. 2002;2:38–47
- Serial immunoreactive erythropoietin levels in autologous blood donors. Transfusion. 1991;31:650–654
- . HIF-1 and tumor progression: Pathophysiology and therapeutics. Trends Mol Med. 2002;8:S62–S67
- HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: Novel mechanism for HIF-1-mediated vascular endothelial growth factor expression. Mol Cell Biol. 2001;21:3995–4004
- Expression of hypoxia-inducible carbonic anhydrase-9 relates to angiogenic pathways and independently to poor outcome in non-small cell lung cancer. Cancer Res. 2001;61:7992–7998
- Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: Implications for tumor angiogenesis and therapeutics. Cancer Res. 2000;60:1541–1545
- Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases. Cancer Res. 1999;59:5830–5835
- Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: Implications for tumor angiogenesis and therapeutics. Cancer Res. 2000;60:1541–1545
- Loss of PTEN facilitates HIF-1-mediated gene expression. Genes Dev. 2000;14:391–396
- Phosphatidylinositol 3-kinase signaling controls levels of hypoxia-inducible factor 1. Cell Growth Differ. 2001;12:363–369
- . Targeting HIF-1 for cancer therapy. Nat Rev Cancer. 2003;3:721–732
- TSC2 regulates VEGF through mTOR-dependent and -independent pathways. Cancer Cell. 2003;4:147–158
- . Molecular basis of the VHL hereditary cancer syndrome. Nat Rev Cancer. 2002;2:673–682
- Molecular genetic studies of sporadic and familial renal cell carcinoma. Urol Clin North Am. 1993;20:207–216
- Mutations of the VHL tumour suppressor gene in renal carcinoma. Nat Genet. 1994;7:85–90
- Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma. Proc Natl Acad Sci U S A. 1994;91:9700–9704
- The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature. 1999;399:271–275
- Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein. Nat Cell Biol. 2000;2:423–427
- The contribution of VHL substrate binding and HIF1-alpha to the phenotype of VHL loss in renal cell carcinoma. Cancer Cell. 2002;1:247–255
- Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein. Cancer Cell. 2002;1:237–246
- . Regulation of translation initiation by FRAP/mTOR. Genes Dev. 2001;15:807–826
- . Control of translation by the target of rapamycin proteins. Prog Mol Subcell Biol. 2001;27:143–174
- CCI-779, a rapamycin analog and multifaceted inhibitor of signal transduction: A phase I study. Proc Am Soc Clin Oncol. 2000;19:726A;(abstr)
- . Mechanisms of resistance to rapamycins. Drug Resist Updat. 2001;4:378–391
- Antitumor efficacy of intermittent treatment schedules with the rapamycin derivative RAD001 correlates with prolonged inactivation of ribosomal protein S6 kinase 1 in peripheral blood mononuclear cells. Cancer Res. 2004;64:252–261
- . Mammalian target of rapamycin as a therapeutic target in leukemia. Curr Mol Med. 2005;5:653–661
- . The mammalian target of the rapamycin (mTOR) kinase pathway: Its role in tumourigenesis and targeted antitumour therapy. Cell Mol Biol Lett. 2005;10:479–498
- Population pharmacokinetics of CCI-779: Correlations to safety and pharmacogenomic responses in patients with advanced renal cancer. Clin Pharmacol Ther. 2005;77:76–89
- CCI-779, a rapamycin analogue with antitumor activity: A phase I study utilizing a weekly schedule. Proc Am Soc Clin Oncol. 2000;19:187a;(abstr)
- . Targeting the molecular target of rapamycin (mTOR). Curr Opin Oncol. 2004;16:564–575
- Low expression of surrogates for mTOR pathway activation predict for resistance to CCI-779 in patients with advanced renal cell carcinoma (RCC). Philadelphia, PA: ASCO/AACR/EORTC International Conference on Medical Therapeutics; 2005;
- Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR. Proc Natl Acad Sci U S A. 2001;98:10314–10319
- Analysis of the phosphatidylinositol 3′-kinase signaling pathway in glioblastoma patients in vivo. Cancer Res. 2003;63:2742–2746
- Antibody-based profiling of the phosphoinositide 3-kinase pathway in clinical prostate cancer. Clin Cancer Res. 2004;10:8351–8356
- Characterization of the mTOR pathway in renal cell carcinoma and its use in predicting patient selection for agents targeting this pathway. J Urol. 2005;173:96a;(abstr)
- Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer. Nat Med. 2006;12:122
PII: S0093-7754(06)00268-5
doi: 10.1053/j.seminoncol.2006.06.002
© 2006 Elsevier Inc. All rights reserved.
« Previous
Next »
Seminars in Oncology
Volume 33, Issue 5
, Pages 607-613
, October 2006
