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Seminars in Oncology
Volume 33, Issue 5
, Pages 563-575
, October 2006
Prognostic Factors in Renal Cell Carcinoma
References
- Cancer statistics, 2006. CA Cancer J Clin. 2006;56:106–130
- Surveillance following radical or partial nephrectomy for renal cell carcinoma. Curr Urol Rep. 2005;6:7–18
- TNM staging of renal cell carcinoma: Workgroup No. 3 (Union International Contre le Cancer (UICC) and the American Joint Committee on Cancer (AJCC)). Cancer. 1997;80:992–993
- Radical extensive surgery for renal cell carcinoma: Long-term results and prognostic factors. J Urol. 1990;143:468–473
- . Prognostic factors in renal cell carcinoma. Urol Clin North Am. 2003;30:467–480
- . Nephron sparing surgery for localized renal cell carcinoma: impact of tumor size on patient survival, tumor recurrence and TNM staging. J Urol. 1999;162:1930–1933
- Disease outcome in patients with low stage renal cell carcinoma treated with nephron sparing or radical surgery. J Urol. 1996;155:1868–1873
- . In: TNM Classification of Malignant Tumours. (ed 6).. New York, NY: Wiley-Liss; 2002;p. 193
- Safety and efficacy of partial nephrectomy for all T1 tumors based on an international multicenter experience. J Urol. 2004;171:2181–2185
- Nephron sparing surgery for appropriately selected renal cell carcinoma between 4 and 7 cm results in outcome similar to radical nephrectomy. J Urol. 2004;171:1066–1070
- Independent validation of the 2002 American Joint Committee on Cancer primary tumor classification for renal cell carcinoma using a large, single institution cohort. J Urol. 2005;173:1889–1892
- Stage pT1 conventional (clear cell) renal cell carcinmoa: Pathological features associated with cancer specific survival. J Urol. 2001;166:453–456
- Proposal for revision of the TNM classification system for renal cell carcinoma. Cancer. 2005;104:2116–2123
- Prognostic indicators for renal cell carcinoma: A multivariate analysis of 643 patients using the revised 1997 TNM staging criteria. J Urol. 2000;163:1090–1095
- pT2 classification for renal cell carcinoma (Can its accuracy be improved?). J Urol. 2005;173:380–384
- Can pT2 classification for renal cell carcinoma be improved? (An international multicenter experience). J Urol. 2006;175(suppl):240–241
- Significance of tumor size in locally advanced renal cell carcinoma (pT3a): An international multicenter experience. J Urol. 2006;175(suppl):234
- TNM T3a renal cell carcinoma: Adrenal gland involvement is not the same as renal fat invasion. J Urol. 2003;169:899–903
- Should direct ipsilateral adrenal invasion from renal cell carcinoma be classified as pT3a?. J Urol. 2005;173:918–921
- Reclassification of patients with pT3 and pT4 renal cell carcinoma improves prognostic accuracy. Cancer. 2005;104:53–60
- Prognostic significance of T3a renal cell carcinoma with adrenal gland involvement: an international multicenter experience. J Urol. 2005;173(suppl):269–270
- Is renal sinus fat invasion the same as perinephric fat invasion for pT3a renal cell carcinoma?. J Urol. 2005;174:1218–1221
- Cancer specific survival for patients with pT3 renal cell carcinoma—Can the 2002 primary tumor classification be improved?. J Urol. 2005;173:716–719
- Prognostic significance of venous thrombus in renal cell carcinoma (Are renal vein and inferior vena cava involvement different?). J Urol. 2004;171:588–591
- . Prognostic significance of tumor thrombus level in patients with renal cell carcinoma and venous tumor thrombus extension (Is all T3b the same?). J Urol. 2004;171:598–601
- The Mayo Clinic experience with surgical management, complications and outcome for patients with renal cell carcinoma and venous tumour thrombus. BJU Int. 2004;94:33–41
- Renal cell carcinoma with retroperitoneal lymph nodes (Impact on survival and benefits of immunotherapy). Cancer. 2003;97:2995–3002
- Renal cell carcinoma with retroperitoneal lymph nodes: role of lymph node dissection. J Urol. 2003;169:2076–2083
- Lack of retroperitoneal lymphadenopathy predicts survival of patients with metastatic renal cell carcinoma. J Urol. 2001;166:68–72
- . Aggressive surgical approach to renal cell carcinoma: Review of 130 cases. J Urol. 1979;122:306–309
- Enlargement of regional lymph nodes in renal cell carcinoma is often not due to metastases. J Urol. 1990;144:243–245
- . Advances in immune-based therapies of renal cell carcinoma. Expert Rev Anticancer Ther. 2004;4:1081–1096
- . Interferon-alpha and survival in metastatic renal carcinoma: Early results of a randomised controlled trial. Lancet. 1999;353:14–17
- Nephrectomy followed by interferon alfa-2b compared with interferon alfa-2b alone for metastatic renal-cell cancer. N Engl J Med. 2001;345:1655–1659
- Radical nephrectomy plus interferon-alfa-based immunotherapy compared with interferon alfa alone in metastatic renal-cell carcinoma: A randomised trial. Lancet. 2001;358:966–970
- Cytoreductive nephrectomy in patients with metastatic renal cancer: A combined analysis. J Urol. 2004;171:1071–1076
- The role of adjunctive nephrectomy in patients with metastatic renal cell carcinoma. J Urol. 1977;117:272–275
- Regression of metastatic renal cell carcinoma after cytoreductive nephrectomy. J Urol. 1993;150:463–466
- . The natural history of metastatic renal cell carcinoma: A computer analysis. J Urol. 1978;120:148–152
- Survival and prognostic stratification of 670 patients with advanced renal cell carcinoma. J Clin Oncol. 1999;17:2530–2540
- . Metastatic renal cell cancer and radical nephrectomy: Identification of prognostic factors and patient survival. J Urol. 1988;139:1173–1176
- Interleukin-2-based immunotherapy for the treatment of metastatic renal cell carcinoma: an analysis of 203 consecutively treated patients. Cancer J Sci Am. 1997;3(suppl 1):S92–S97
- Prognostic factors for survival in patients with metastatic renal cancer treated with biological response modifiers. J Urol. 1995;154:35–40
- Association of radionuclide bone scan and serum alkaline phosphatase in patients with metastatic renal cell carcinoma. Urology. 1996;48:692–695
- Number of metastatic sites rather than location dictates overall survival of patients with node-negative metastatic renal cell carcinoma. Urology. 2003;61:314–319
- . Prognostic significance of morphologic parameters in renal cell carcinoma. Am J Surg Pathol. 1982;6:655–663
- Prognostic value of nuclear grade of renal cell carcinoma. Cancer. 1995;76:2543–2549
- Classification of renal cell carcinoma: Workgroup No. 1 (Union Internationale Contre le Cancer (UICC) and the American Joint Committee on Cancer (AJCC)). Cancer. 1997;80:987–989
- Collecting duct renal cell carcinoma: Clinical study of a rare tumor. J Urol. 2002;167:71–74
- . Renal medullary carcinoma (The seventh sickle cell nephropathy). Am J Surg Pathol. 1995;19:1–11
- Morphologic typing of papillary renal cell carcinoma: Comparison of growth kinetics and patient survival in 66 cases. Hum Pathol. 2001;32:590–595
- A molecular classification of papillary renal cell carcinoma. Cancer Res. 2005;65:5628–5637
- Prognostic impact of histologic subtyping of adult renal epithelial neoplasms: An experience of 405 cases. Am J Surg Pathol. 2002;26:281–291
- Comparisons of outcome and prognostic features among histologic subtypes of renal cell carcinoma. Am J Surg Pathol. 2003;27:612–624
- Prognostic value of histologic subtypes in renal cell carcinoma: A multicenter experience. J Clin Oncol. 2005;23:2763–2771
- Treatment outcome and survival associated with metastatic renal cell carcinoma of non-clear-cell histology. J Clin Oncol. 2002;20:2376–2381
- Histologic predictors of renal cell carcinoma response to interleukin-2-based therapy. J Immunother. 2005;28:488–495
- . Sarcomas and sarcomatoid and mixed malignant tumors of the kidney in adults. Cancer. 1968;22:556–563
- . The current state of renal cell carcinoma grading (Union Internationale Contre le Cancer (UICC) and the American Joint Committee on Cancer (AJCC)). Cancer. 1997;80:977–980
- Sarcomatoid renal cell carcinoma: Biologic behavior, prognosis, and response to combined surgical resection and immunotherapy. J Clin Oncol. 1999;17:523–528
- Sarcomatoid differentiation in renal cell carcinoma: A study of 101 cases. Am J Surg Pathol. 2001;25:275–284
- Prognostic utility of the recently recommended histologic classification and revised TNM staging system of renal cell carcinoma: A Swiss experience with 588 tumors. Cancer. 2000;89:604–614
- Sarcomatoid carcinoma of the kidney. J Urol. 1987;137:25–28
- An outcome prediction model for patients with clear cell renal cell carcinoma treated with radical nephrectomy based on tumor stage, size, grade and necrosis: The SSIGN score. J Urol. 2002;168:2395–2400
- Clinicopathologic and molecular correlations of necrosis in the primary tumor of patients with renal cell carcinoma. Cancer. 2005;103:2517–2525
- Histologic coagulative tumor necrosis as a prognostic indicator of renal cell carcinoma aggressiveness. Cancer. 2005;104:511–520
- Microscopic vascular invasion is the most relevant prognosticator after radical nephrectomy for clinically nonmetastatic renal cell carcinoma. J Urol. 1997;158:45–49
- Low clinical stage renal cell carcinoma: Relevance of microvascular tumor invasion as a prognostic parameter. J Urol. 2004;172:470–474
- Renal cell carcinoma invading the urinary collecting system: Implications for staging. J Urol. 2002;167:2392–2396
- Collecting system invasion in renal cell carcinoma: Impact on prognosis and future staging strategies. J Urol. 2003;170:768–772
- Prognostic value of the involvement of the urinary collecting system in renal cell carcinoma. Eur Urol. 2004;46:472–476
- Nephrectomy before interleukin-2 therapy for patients with metastatic renal cell carcinoma. J Urol. 1997;158:1691–1695
- Improved prognostication of renal cell carcinoma using an integrated staging system. J Clin Oncol. 2001;19:1649–1657
- Cachexia-like symptoms predict a worse prognosis in localized t1 renal cell carcinoma. J Urol. 2004;171:1810–1813
- Paraneoplastic signs and symptoms of renal cell carcinoma: Implications for prognosis. J Urol. 2003;170:1742–1746
- Poor prognosis associated with thrombocytosis in patients with renal cell carcinoma. BJU Int. 2000;86:203–207
- Significance of thrombocytosis for determining prognosis in patients with localized renal cell carcinoma. Urology. 2004;63:447–450
- . Prognostic factors in metastatic renal carcinoma. J Urol. 1986;136:376–379
- . Prognostic factors for survival in patients with recurrent or metastatic renal cell carcinoma. Cancer Res. 1988;48:7310–7313
- Interferon-alfa as a comparative treatment for clinical trials of new therapies against advanced renal cell carcinoma. J Clin Oncol. 2002;20:289–296
- Validation and extension of the Memorial Sloan-Kettering prognostic factors model for survival in patients with previously untreated metastatic renal cell carcinoma. J Clin Oncol. 2005;23:832–841
- . Prognostic factors in patients with advanced renal cell carcinoma: Development of an international kidney cancer working group. Clin Cancer Res. 2004;10:6310S–6314S
- Prognostic factors of survival and rapid progression in 782 patients with metastatic renal carcinomas treated by cytokines: A report from the Groupe Francais d’Immunotherapie. Ann Oncol. 2002;13:1460–1468
- Prognostic factors for survival in previously treated patients with metastatic renal cell carcinoma. J Clin Oncol. 2004;22:454–463
- A postoperative prognostic nomogram for renal cell carcinoma. J Urol. 2001;166:63–67
- Risk group assessment and clinical outcome algorithm to predict the natural history of patients with surgically resected renal cell carcinoma. J Clin Oncol. 2002;20:4559–4566
- Use of the University of California Los Angeles integrated staging system to predict survival in renal cell carcinoma: An international multicenter study. J Clin Oncol. 2004;22:3316–3322
- Comparison of predictive accuracy of four prognostic models for nonmetastatic renal cell carcinoma after nephrectomy: A multicenter European study. Cancer. 2005;104:1362–1371
- Predicting survival in patients with metastatic kidney cancer by gene-expression profiling in the primary tumor. Proc Natl Acad Sci U S A. 2003;100:6958–6963
- Gene expression profiling of renal cell carcinoma. Clin Cancer Res. 2004;10:6315S–6321S
- Using protein expressions to predict survival in clear cell renal carcinoma. Clin Cancer Res. 2004;10:5464–5471
- Using tumor markers to predict the survival of patients with metastatic renal cell carcinoma. J Urol. 2005;173:1496–1501
- Renal cell carcinoma 2005: New frontiers in staging, prognostication and targeted molecular therapy. J Urol. 2005;173:1853–1862
- Role of molecular markers in the diagnosis and therapy of renal cell carcinoma. Urology. 2005;66:1–9
- . Hypoxia—A key regulatory factor in tumour growth. Nat Rev Cancer. 2002;2:38–47
- . HIF-1 and tumor progression: Pathophysiology and therapeutics. Trends Mol Med. 2002;8:S62–S67
- The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature. 1999;399:271–275
- Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein. Nat Cell Biol. 2000;2:423–427
- . Molecular targeting of VHL gene pathway in clear cell kidney cancer. J Urol. 2003;170:593–594
- Expression of hypoxia-inducible cell-surface transmembrane carbonic anhydrases in human cancer. Am J Pathol. 2001;158:905–919
- The expression of hypoxia-inducible factor 1alpha is a favorable independent prognostic factor in renal cell carcinoma. Clin Cancer Res. 2005;11:1129–1135
- Carbonic anhydrase IX is an independent predictor of survival in advanced renal clear cell carcinoma: Implications for prognosis and therapy. Clin Cancer Res. 2003;9:802–811
- Carbonic anhydrase IX expression predicts outcome of interleukin 2 therapy for renal cancer. Clin Cancer Res. 2005;11:3714–3721
- Identification of the von Hippel-Lindau disease tumor suppressor gene. Science. 1993;260:1317–1320
- Mutations of the VHL tumour suppressor gene in renal carcinoma. Nat Genet. 1994;7:85–90
- VHL tumor suppressor gene alterations associated with good prognosis in sporadic clear-cell renal carcinoma. J Natl Cancer Inst. 2002;94:1569–1575
- . The biology of VEGF and its receptors. Nat Med. 2003;9:669–676
- Targeting the vascular endothelial growth factor pathway in renal cell carcinoma, a tissue array based analysis. J Clin Oncol. 2005;23(suppl):386s
- Expression of the vascular endothelial growth factor family in tumor dissemination and disease free survival in clear cell renal cell carcinoma. In: J Clin Oncol. 2005;23(suppl):387s
- . Cancer (p53, guardian of the genome). Nature. 1992;358:15–16
- p53 protein expression but not mdm-2 protein expression is associated with rapid tumor cell proliferation and prognosis in renal cell carcinoma. Urol Res. 1997;25(suppl 1):S25–S30
- Value of p53 as a prognostic marker in histologic subtypes of renal cell carcinoma: A systematic analysis of primary and metastatic tumor tissue. Urology. 2004;63:651–655
- p53 is an independent predictor of tumor recurrence and progression after nephrectomy in patients with localized renal cell carcinoma. J Urol. 2005;173:725–728
- . P53, bcl-2, and Bax expression in renal cell carcinoma. Urology. 1998;51:1057–1061
- Conventional (clear cell) renal carcinoma metastases have greater bcl-2 expression than high-risk primary tumors. Urol Oncol. 2003;21:179–184
- Impact of frequent Bcl-2 expression on better prognosis in renal cell carcinoma patients. Br J Cancer. 2004;90:200–205
- Downregulation of Smac/DIABLO expression in renal cell carcinoma and its prognostic significance. J Clin Oncol. 2005;23:448–454
- Molecular determinants of the caspase-promoting activity of Smac/DIABLO and its role in the death receptor pathway. J Biol Chem. 2000;275:36152–36157
- Low expression of p27(Kip1) is associated with tumor size and poor prognosis in patients with renal cell carcinoma. Cancer. 2002;94:973–979
- Expression of cyclin D1, D3, E, and p27 in human renal cell carcinoma analysed by tissue microarray. Br J Cancer. 2003;88:1417–1423
- Characterization of the mTOR pathway in renal cell carcinoma and its use in predicting patient selection for agents targeting this pathway. J Urol. 2005;173(suppl):96
- Epithelial cell adhesion molecule (KSA) expression: pathobiology and its role as an independent predictor of survival in renal cell carcinoma. Clin Cancer Res. 2004;10:2659–2669
- Expression of EphA2 is prognostic of disease-free interval and overall survival in surgically treated patients with renal cell carcinoma. Clin Cancer Res. 2005;11:226–231
Supported in part by the Richard and Nancy Bloch Kidney Cancer Research Fund.
PII: S0093-7754(06)00272-7
doi: 10.1053/j.seminoncol.2006.06.006
© 2006 Elsevier Inc. All rights reserved.
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Seminars in Oncology
Volume 33, Issue 5
, Pages 563-575
, October 2006
