« Previous
Next »
Seminars in Oncology
Volume 33
, Pages S1-S7
, October 2006
Mechanisms of Action of Bevacizumab as a Component of Therapy for Metastatic Colorectal Cancer
References
- . The growth of malignant disease in man and the lower animals with special reference to the vascular system. Lancet. 1907;2:1236–1240
- . Tumor angiogenesis: Therapeutic implications. N Engl J Med. 1971;285:1182–1186
- Vascular permeability factor, an endothelial cell mitogen related to PDGF. Science. 1989;246:1309–1312
- Vascular endothelial growth factor is a secreted angiogenic mitogen. Science. 1989;246:1306–1309
- Nexavar (sorafenib) prescribing information. Emeryville, CA: Onyx Pharmaceuticals; 2005;
- Sutent (sunitinib malate) prescribing information. New York, NY: Pfizer; 2006;
- . Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell. 1996;86:353–364
- . The hallmarks of cancer. Cell. 2000;100:57–70
- . Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. J Clin Oncol. 2005;23:1011–1027
- . Angiogenesis in cancer and other diseases. Nature. 2000;407:249–256
- Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF. Science. 1999;284:1994–1998
- Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis. Am J Pathol. 1995;146:1029–1039
- Improving delivery of antineoplastic agents with anti-vascular endothelial growth factor therapy. Cancer. 2005;103:1561–1570
- Abnormalities in pericytes on blood vessels and endothelial sprouts in tumors. Am J Pathol. 2002;160:985–1000
- Abnormalities of basement membrane on blood vessels and endothelial sprouts in tumors. Am J Pathol. 2003;163:1801–1815
- Mosaic blood vessels in tumors: Frequency of cancer cells in contact with flowing blood. Proc Natl Acad Sci U S A. 2000;97:14608–14613
- Openings between defective endothelial cells explain tumor vessel leakiness. Am J Pathol. 2000;156:1363–1380
- The vesiculo-vacuolar organelle (VVO): A distinct endothelial cell structure that provides a transcellular pathway for macromolecular extravasation. J Leukoc Biol. 1996;59:100–115
- . Vascular permeability factor/vascular endothelial growth factor: A critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy. J Clin Oncol. 2002;20:4368–4380
- Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer. Nat Rev Drug Discov. 2004;3:391–400
- . The biology of VEGF and its receptors. Nat Med. 2003;9:669–676
- Vascular endothelial growth factor receptor-1 promotes migration and invasion in pancreatic carcinoma cell lines. Cancer. 2005;104:427–438
- . Clinical translation of angiogenesis inhibitors. Nat Rev Cancer. 2002;2:727–739
- . Targeting HIF-1 for cancer therapy. Nat Rev Cancer. 2003;3:721–732
- Endothelial cell death, angiogenesis, and microvascular function after castration in an androgen-dependent tumor: Role of vascular endothelial growth factor. Proc Natl Acad Sci U S A. 1998;95:10820–10825
- Blockade of insulin-like growth factor I receptor function inhibits growth and angiogenesis of colon cancer. Clin Cancer Res. 2002;8:3259–3269
- . Vascular endothelial growth factor receptors: Expression and function in solid tumors. Clin Adv Hematol Oncol. 2004;2:37–45
- Vascular endothelial growth factor is an autocrine survival factor for neuropilin-expressing breast carcinoma cells. Cancer Res. 2001;61:5736–5740
- Overexpression of neuropilin-1 promotes constitutive MAPK signalling and chemoresistance in pancreatic cancer cells. Br J Cancer. 2005;93:233–241
- Expression and function of endothelial growth factor receptor-1 on human colorectal cancer cells. Oncogene. 2005;24:2647–2653
- Vascular endothelial growth factors receptor-1 activation mediates epithelial to mesenchymal transition in human pancreatic carcinoma cells. Cancer Res. 2006;66:46–51
- VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche. Nature. 2005;438:820–827
- Vessel counts and expression of vascular endothelial growth factor as prognostic factors in node-negative colon cancer. Arch Surg. 1997;132:541–546
- Humanization of an anti-vascular endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disorders. Cancer Res. 1997;57:4593–4599
- Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal. J Clin Invest. 1999;103:159–165
- . A plasticity window for blood vessel remodelling is defined by pericyte coverage of the preformed endothelial network and is regulated by PDGF-B and VEGF. Development. 1998;125:1591–1598
- Induction of VEGF in perivascular cells defines a potential paracrine mechanism for endothelial cell survival. FASEB J. 2001;15:1239–1241
- Stable expression of angiopoietin-1 and other markers by cultured pericytes: Phenotypic similarities to a subpopulation of cells in maturing vessels during later stages of angiogenesis in vivo. Lab Invest. 2002;82:387–401
- . N-cadherin mediates pericyte-endothelial interaction during brain angiogenesis in the chicken. Dev Dyn. 2000;218:472–479
- Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors. J Clin Invest. 2003;111:1287–1295
- . A multitargeted, metronomic, and maximum-tolerated dose “chemo-switch” regimen is antiangiogenic, producing objective responses and survival benefit in a mouse model of cancer. J Clin Oncol. 2005;23:939–952
- Tyrosine kinase inhibition of multiple angiogenic growth factor receptors improves survival in mice bearing colon cancer liver metastases by inhibition of endothelial cell survival mechanisms. Cancer Res. 2001;61:1464–1468
- Combined inhibition of VEGF and PDGF signaling enforces tumor vessel regression by interfering with pericyte-mediated endothelial cell survival mechanisms. FASEB J. 2004;18:338–340
- Inhibition of vascular endothelial growth factor (VEGF) signaling in cancer causes loss of endothelial fenestrations, regression of tumor vessels, and appearance of basement membrane ghosts. Am J Pathol. 2004;165:35–52
- Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer [erratum in: Nat Med 10;649, 2004]. Nat Med. 2004;10:145–147
- . Clinical benefit from bevacizumab (BV) in responding (R) and non-responding (NR) patients (pts) with metastatic colorectal cancer (mCRC). J Clin Oncol. 2005;23(suppl):249s;(abstr 3514)
- Response rate using conventional criteria is a poor surrogate for clinical benefit on progression-free (PFS) and overall survival (OS) in metastatic colorectal cancer (mCRC): A comparative analysis of N9741 and AVF2107. J Clin Oncol. 2006;24(suppl):150s;(abstr 3516)
- Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene. Cancer Cell. 2003;3:347–361
- Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol Cell Biol. 1996;16:4604–4613
- V-SRC induces expression of hypoxia-inducible factor 1 (HIF-1) and transcription of genes encoding vascular endothelial growth factor and enolase 1: Involvement of HIF-1 in tumor progression. Cancer Res. 1997;57:5328–5335
- Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration. Nat Genet. 2001;28:131–138
- . Barriers to drug delivery in solid tumors. Sci Am. 1994;271:58–65
- . Biological consequences of tumor hypoxia. Semin Oncol. 2001;28(suppl):36–41
- . Normalizing tumor vasculature with antiangiogenic therapy: A new paradigm for combination therapy. Nat Med. 2001;7:987–989
- Vascular normalization by vascular endothelial growth factor receptor 2 blockade induces a pressure gradient across the vasculature and improves drug penetration in tumors. Cancer Res. 2004;64:3731–3736
- Effect of antivascular endothelial growth factor treatment on the intratumoral uptake of CPT-11. Br J Cancer. 2003;88:1979–1986
- Effect of inhibition of vascular endothelial growth factor signaling on distribution of extravasated antibodies in tumors. Cancer Res. 2006;66:1434–1445
- Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med. 2004;350:2335–2342
- A randomized phase III trial of paclitaxel versus paclitaxel plus bevacizumab as first-line therapy for locally recurrent or metastatic breast cancer. 2005;Presented at the 41st Annual Meeting of the American Society of Clinical Oncology, Orlando, FL, May 13-17
- Randomized phase II/III trial of paclitaxel (P) plus carboplatin (C) with or without bevacizumab (NSC #704865) in patients with advanced non-squamous non–small cell lung cancer (NSCLC): An Eastern Cooperative Oncology Group (ECOG) trial – E4599. J Clin Oncol. 2005;23(suppl):2s;(abstr 4)
- High-dose bevacizumab improves survival when combined with FOLFOX4 in previously treated advanced colorectal cancer: Results from the Eastern Cooperative Oncology Group (ECOG) study E3200. J Clin Oncol. 2005;23(suppl):1s;(abstr 2)
- Semaphorin SEMA3F and VEGF have opposing effects on cell attachment and spreading. Neoplasia. 2003;5:83–92
- Semaphorin SEMA3F has a repulsing activity on breast cancer cells and inhibits E-cadherin-mediated cell adhesion. Neoplasia. 2005;7:180–189
- Competing autocrine pathways involving alternative neuropilin-1 ligands regulate chemotaxis of carcinoma cells. Cancer Res. 2003;63:5230–5233
- Antiangiogenic and antitumor effects of bevacizumab in patients with inflammatory and locally advanced breast cancer. J Clin Oncol. 2006;24:769–777
This work was supported in part by the Lustgarten Foundation for Pancreatic Cancer Research, National Institutes of Health grant no. CA112390, and the Lockton Fund for Pancreatic Cancer Research. The author thanks Genentech, Inc, for providing financial support for the editorial services of ApotheCom Associates.
PII: S0093-7754(06)00313-7
doi: 10.1053/j.seminoncol.2006.08.002
© 2006 Elsevier Inc. All rights reserved.
« Previous
Next »
Seminars in Oncology
Volume 33
, Pages S1-S7
, October 2006
