« Previous
Next »
Seminars in Oncology
Volume 33
, Pages S35-S40
, October 2006
Combined Vascular Endothelial Growth Factor–Targeted Therapy and Radiotherapy for Rectal Cancer: Theory and Clinical Practice
References
- National Comprehensive Cancer Network: NCCN Clinical Practice Guidelines: Colon Cancer—v.2.2006. http://www.nccn.org/professionals/physician_gls/default.asp (accessed July 17, 2006).
- National Comprehensive Cancer Network: NCCN Clinical Practice Guidelines: Rectal Cancer—v.2.2006. http://www.nccn.org/professionals/physician_gls/default.asp (accessed July 17, 2006).
- Preoperative radiotherapy combined with total mesorectal excision for respectable rectal cancer. N Engl J Med. 2001;345:638–646
- Are there patients with stage I rectal carcinoma at risk for failure after abdominoperineal resection?. Cancer. 1992;69:1651–1655
- Cancer statistics, 2006. CA Cancer J Clin. 2006;56:106–130
- Patterns of recurrence of rectal cancer after potentially curative surgery. Cancer. 1983;34:1317–1329
- Preoperative versus postoperative chemoradiotherapy for rectal cancer. N Engl J Med. 2004;351:1731–1740
- Randomized trial of postoperative adjuvant chemotherapy with or without radiotherapy for carcinoma of the rectum: National Surgical Adjuvant Breast and Bowel Project Protocol R-02. J Natl Cancer Inst. 2000;95:388–396
- . Tumor response to ionizing radiation combined with antiangiogenesis or vascular targeting agents: Exploring mechanisms of interaction. Clin Cancer Res. 2003;9:1957–1971
- . Radiation combined with antiangiogenic and antivascular agents. Semin Radiat Oncol. 2006;16:45–50
- Comparison of several antiangiogenic regimens alone and with cytotoxic therapies in the Lewis lung carcinoma. Cancer Chemother Pharmacol. 1996;38:169–177
- Combined effects of angiostatin and ionizing radiation in antitumor therapy. Nature. 1998;394:287–291
- . An antiangiogenic agent (TNP-470) inhibited reoxygenation during fractionated radiotherapy of murine mammary carcinoma. Int J Radiat Oncol Biol Phys. 1997;37:1107–1113
- Blockage of the vascular endothelial growth factor stress response increases the antitumor effects of ionizing radiation. Cancer Res. 1999;59:3374–3378
- Anti-vascular endothelial growth factor treatment augments tumor radiation response under normoxic or hypoxic conditions. Cancer Res. 2000;60:5565–5570
- Vascular endothelial growth factor receptor-2-blocking antibody potentiates radiation-induced long-term control of human tumor xenografts. Cancer Res. 2001;61:39–44
- Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: Role of oxygenation, angiopoietin-1, and matrix metalloproteinases. Cancer Cell. 2004;6:553–563
- Angiogenesis and radiation response modulation after vascular endothelial growth factor receptor-2 (VEGFR2) blockade. Int J Radiat Oncol Biol Phys. 2005;62:1477–1485
- Thalidomide radiosensitizes tumors through early changes in the tumor microenvironment. Clin Cancer Res. 2005;11:743–750
- Lessons from phase III clinical trials on anti-VEGF therapy for cancer. Nat Clin Pract Oncol. 2006;3:24–40
- . Angiogenesis in life, disease and medicine. Nature. 2005;438:932–936
- Tumor response to radiotherapy regulated by endothelial cell apoptosis. Science. 2003;300:1155–1159
- Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer. Nat Med. 2004;10:145–147
- Surrogate markers for antiangiogenic therapy and dose-limiting toxicities for bevacizumab with radiation and chemotherapy: Continued experience of a phase I trial in rectal cancer patients. J Clin Oncol. 2005;23:8136–8139
- Clinicaltrials.gov. 2006. http://www.clinicaltrials.gov/ct/show/NCT00321685?order=1 (accessed June 12, 2006).
- Clinicaltrials.gov. 2006. http://www.clinicaltrials.gov/ct/show/NCT00113230?order=7 (accessed June 12, 2006).
This work was supported by grants from the National Institutes of Health-National Cancer Institute (R21-CA 99237 to C.G.W. and P01-CA80124 and R01-CA115767 to R.K.J.), the National Foundation for Cancer Research (to R.K.J. and C.G.W.), and the American Association for Cancer Research (to D.G.D.).
PII: S0093-7754(06)00318-6
doi: 10.1053/j.seminoncol.2006.08.007
© 2006 Elsevier Inc. All rights reserved.
« Previous
Next »
Seminars in Oncology
Volume 33
, Pages S35-S40
, October 2006
