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Seminars in Oncology
Volume 33
, Pages 28-32
, December 2006
Planned Treatment Interruptions and Chemotherapy-Free Intervals in the Treatment of Metastatic Colorectal Cancer: Time to Start Stopping?
References
- Green E, Sargent DJ, Goldberg RM, et al: Detailed analysis of oxaliplatin-associated neurotoxicity in Intergroup trial N9741. Presented at 2005 ASCO Gastrointestinal Cancers Symposium: Multidisciplinary Approaches to Gastrointestinal Malignancies and Premalignancies, January 27–29, 2005, Hollywood, FL. (abstr 182). Available at: http://www.asco.org
- OPTIMOX1: A randomized study of FOLFOX4 or FOLFOX7 with oxaliplatin in a stop-and-go fashion in advanced colorectal cancer: A GERCOR study. J Clin Oncol. 2006;24:394–400
- OPTIMOX2, a large randomized phase II study of maintenance therapy or chemotherapy-free intervals (CFI) after FOLFOX in patients with metastatic colorectal cancer (MRC): A GERCOR study. J Clin Oncol. 2006;24(suppl):3504A;(abstr)
- Alternating versus continuous FOLFIRI in advanced colorectal cancer (ACC): A randomized GISCAD trial. J Clin Oncol. 2006;24(suppl):3505A;(abstr)
- OPTIMOX study: Influence of reintroduction rate on survival. Ann Oncol. 2004;15(suppl 3):344P;(abstr)
- A randomized trial comparing defined-duration with continuous irinotecan until disease progression in fluoropyrimidine and thymidylate synthase inhibitor-resistant advanced colorectal cancer. J Clin Oncol. 2004;22:3023–3031
- Bevacizumab (BV) plus 5-FU/leucovorin (FU/LV) for advanced colorectal cancer (CRC) that progressed after standard chemotherapies: An NCI Treatment Referral Center trial (TRC-0301). J Clin Oncol. 2006;22(suppl):3515A;(abstr)
- High-dose bevacizumab improves survival when combined with FOLFOX4 in previously treated advanced colorectal cancer: Results from the Eastern Cooperative Oncology Group (ECOG) study E3200. J Clin Oncol. 2005;23(suppl):2A;(abstr)
Dr Saltz has served as a paid consultant to Pfizer, Sanofi-Aventis, and Amgen. He has received research grant support from Bristol-Myers Squibb, Pfizer, Imclone, Genentech, and Roche.
PII: S0093-7754(06)00386-1
doi: 10.1053/j.seminoncol.2006.10.009
© 2006 Elsevier Inc. All rights reserved.
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Seminars in Oncology
Volume 33
, Pages 28-32
, December 2006
