« Previous
Next »
Seminars in Oncology
Volume 34, Issue 2
, Pages 154-164
, April 2007
New Molecular Targets and Novel Agents in the Treatment of Advanced Urothelial Cancer
References
- Preliminary results of M-VAC (methotrexate, vinblastine, doxorubicin and cisplatin) for transitional cell carcinoma of the urothelium. J Urol. 1985;133:403–407
- A randomized comparison of cisplatin alone or in combination with methotrexate, vinblastine, and doxorubicin in patients with metastatic urothelial carcinoma: A cooperative group study. J Clin Oncol. 1992;10:1066–1073
- Methotrexate, vinblastine, doxorubicin, and cisplatin for advanced transitional cell carcinoma of the urothelium (Efficacy and patterns of response and relapse). Cancer. 1989;64:2448–2458
- Gemcitabine and cisplatin versus methotrexate, vinblastine, doxorubicin, and cisplatin in advanced or metastatic bladder cancer: Results of a large, randomized, multinational, multicenter, phase III study. J Clin Oncol. 2000;18:3068–3077
- Long-term survival results of a randomized trial comparing gemcitabine plus cisplatin, with methotrexate, vinblastine, doxorubicin, plus cisplatin in patients with bladder cancer. J Clin Oncol. 2005;23:4602–4608
- Phase II study of gemcitabine and cisplatin in patients with advanced or metastatic bladder cancer: Long-term follow-up of a 3-week regimen. Oncology. 2005;69:391–398
- Long-term survival in metastatic transitional-cell carcinoma and prognostic factors predicting outcome of therapy. J Clin Oncol. 1999;17:3173–3181
- . Cancer genetics (Is p53 the only real tumor suppressor gene?). Curr Biol. 1994;4:137–139
- Prognostic implications of p53 gene mutations in bladder tumors. J Urol. 2003;169:492–499
- p53 overexpression as a prognostic factor for advanced stage bladder cancer. Eur J Cancer. 1995;31A:2243–2247
- p53, p21, pRB, and p16 expression predict clinical outcome in cystectomy with bladder cancer. J Clin Oncol. 2004;22:1014–1024
- Cancer statistics, 2007. CA Cancer J Clin. 2007;57:43–66
- Hematologic and cytogenetic responses to imatinib mesylate in chronic myelogenous leukemia. N Engl J Med. 2002;346:645–652
- . Amplification of a novel v-erbB-related gene in a human mammary carcinoma. Science. 1985;229:974–976
- Her-2/neu overexpression in muscle-invasive urothelial carcinoma of the bladder: Prognostic significance and comparative analysis in primary and metastatic tumors. Clin Cancer Res. 2001;7:2440–2447
- Prevalence and clinical significance of HER/2neu, p53 and Rb expression in primary superficial bladder cancer. J Urol. 1996;155:1784–1788
- Expression of c-erbB-2 protein in normal and neoplastic urothelium: Lack of adverse prognostic effect in human urinary bladder cancer. Anticancer Res. 1994;14:1317–1324
- C-erbB-2 gene amplification: A molecular marker in recurrent bladder tumors?. Cancer Res. 1995;55:2422–2430
- Prognostic value of amplification of c-erb-B2 in bladder carcinoma. Clin Cancer Res. 1995;1:1189–1194
- Invasion of the bladder by transitional cell carcinoma: Its relation to histologic grade and expression of p53, MIB-1, c-erb B-2, epidermal growth factor receptor, and bcl-2. Cancer. 1998;82:715–723
- Multinational study of the efficacy and safety of humanized anti-HER2 monoclonal antibody in women who have HER2-overexpressing metastatic breast cancer that has progressed after chemotherapy for metastatic disease. J Clin Oncol. 1999;17:2639–2648
- Trastuzumab (T), paclitaxel (P), carboplatin (C), and gemcitabine (G) in advanced HER2-positive urothelial carcinoma: Results of a multi-center phase II NCI trial. J Clin Oncol. 2005;23(suppl 16):379s;(abstr 4507)
- Paclitaxel, carboplatin, and gemcitabine in the treatment of patients with advanced transitional cell carcinoma of the urothelium. Cancer. 2005;103:2298–2303
- Combined analysis of efficacy: The addition of bevacizumab to fluorouracil/leucovorin improves survival for patients with metastatic colorectal cancer. J Clin Oncol. 2005;23:3706–3712
- Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med. 2004;350:2335–2342
- . Randomized phase II designs in cancer clinical trials: Current status and future directions. J Clin Oncol. 2005;23:4450–4457
- Significance of urinary epidermal growth factor and its receptor expression in human bladder cancer. Anticancer Res. 1997;17:1293–1296
- Expression of epidermal growth factor receptor in invasive transitional cell carcinoma of the urinary bladder (A multivariate survival analysis). Am J Clin Pathol. 1994;101:166–176
- Epidermal-growth-factor receptors in human bladder cancer: Comparison of invasive and superficial tumours. Lancet. 1985;1:366–368
- The epidermal growth factor receptor and the prognosis of bladder cancer. Cancer. 1990;65:1619–1625
- . Clinical implications of the expression of epidermal growth factor receptors in human transitional cell carcinoma. Cancer Res. 1990;50:2530–2537
- Expression of epidermal growth factor receptor in urinary bladder cancer metastases. Int J Cancer. 1998;76:189–193
- Evaluation of the therapeutic potential of the epidermal growth factor receptor tyrosine kinase inhibitor gefitinib in preclinical models of bladder cancer. Clin Cancer Res. 2004;10:4874–4884
- Evaluation of ZD1839 for advanced transitional cell carcinoma (TCC) of the urothelium: A Southwest Oncology Group trial. Proc Am Soc Clin Oncol. 2003;22:403;(abstr 1619)
- Phase II trial of cisplatin, fixed-dose gemcitabine and gefitinib for advanced transitional cell carninoma of the urothelial tract: Preliminary results from CALGB 90102. J Clin Oncol. 2004;22(suppl 14):4540
- Microvessel density at presentation predicts subsequent muscle invasion in superficial bladder cancer. Clin Cancer Res. 2003;9:2583–2586
- Tumor angiogenesis correlates with lymph node metastases in invasive bladder cancer. J Urol. 1995;154:69–71
- Microvessel density as a prognostic marker in bladder carcinoma: Correlation with tumor grade, stage and prognosis. Int Urol Nephrol. 2004;36:401–405
- . The role of vascular endothelial growth factor in pathological angiogenesis. Breast Cancer Res Treat. 1995;36:127–137
- Differential expression of progression-related genes in the evolution of superficial to invasive transitional cell carcinoma of the bladder. Oncol Rep. 2001;8:9–15
- . The expression of vascular endothelial growth factor in transitional cell carcinoma of urinary bladder is correlated with cancer progression. Urol Oncol. 2004;22:1–6
- . The biology of vascular endothelial growth factor. Endocr Rev. 1997;18:4–25
- Vascular endothelial growth factor is a predictor of relapse and stage progression in superficial bladder cancer. Cancer Res. 1997;57:5281–5285
- Serum levels of vascular endothelial growth factor as a prognostic factor in bladder cancer. J Urol. 2001;166:1275–1279
- VEGF receptor expression and signaling in human bladder tumors. Oncogene. 2003;22:3361–3370
- Treatment of human metastatic transitional cell carcinoma of the bladder in a murine model with the anti-vascular endothelial growth factor receptor monoclonal antibody DC101 and paclitaxel. Clin Cancer Res. 2000;6:2635–2643
- Safety, pharmacokinetic, and antitumor activity of SU11248, a novel oral multitarget tyrosine kinase inhibitor, in patients with cancer. J Clin Oncol. 2006;24:25–35
- Phase I trial of SU011248, a novel tyrosine kinase inhibitor in advanced solid tumors. J Clin Oncol. 2003;22:191;(abstr 765)
- Activity of SU11248, a multitargeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor, in patients with metastatic renal cell carcinoma. J Clin Oncol. 2006;24:16–24
- Results of treatment of 255 patients with metastatic renal cell carcinoma who received high-dose recombinant interleukin-2 therapy. J Clin Oncol. 1995;13:688–696
- Recombinant human interleukin-2, recombinant human interferon alfa-2a, or both in metastatic renal-cell carcinoma (Groupe Francais d’Immunotherapie). N Engl J Med. 1998;338:1272–1278
- Phase 3, mulitcenter, randomized, double-blind, placebo-controlled trial of SU11248 in patients following failure of imatinib for metastatic GIST. J Clin Oncol. 2005;23:308s;(abstr 4000)
- Final findings from a phase II, placebo-controlled, randomized discontinuation trial (RDT) of sorafenib (BAY 43-9006) in patients with advanced renal cell carcinoma (RCC). J Clin Oncol. 2005;23:388s;(abstr 4544)
- Randomized phase III trial of the Raf kinase and VEGFR inhibitor sorafenib (BAY 43-9006) in patients with advanced renal cell carcinoma. J Clin Oncol. 2005;23:380s;(abstr LBA4510)
- The murine gene p27Kip1 is haplo-insufficient for tumour suppression. Nature. 1998;396:177–180
- Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas. Nat Med. 1997;3:231–234
- A phase I trial of the novel proteasome inhibitor PS341 in advanced solid tumor malignancies. Clin Cancer Res. 2002;8:2505–2511
- Phase I trial of the proteasome inhibitor bortezomib in patients with advanced solid tumors with observations in androgen-independent prostate cancer. J Clin Oncol. 2004;22:2108–2121
- Phase I trial of the proteasome inhibitor PS-341 in patients with refractory hematologic malignancies. J Clin Oncol. 2002;20:4420–4427
- Bortezomib or high-dose dexamethasone for relapsed multiple myeloma. N Engl J Med. 2005;352:2487–2498
- Phase II study of bortezomib in advanced or metastatic urothelial cancer (A trial of the Princess Margaret Hospital [PMH] Phase II Consortium). J Clin Oncol. 2005;23(suppl 16):422s;(abstr 4677)
- The proteasome inhibitor bortezomib synergizes with gemcitabine to block the growth of human 253JB-V bladder tumors in vivo. Mol Cancer Ther. 2004;3:279–290
- Mi-2 complex couples DNA methylation to chromatin remodelling and histone deacetylation. Nat Genet. 1999;23:62–66
- 17-Allylamino-17-demethoxygeldanamycin induces the degradation of androgen receptor and HER-2/neu and inhibits the growth of prostate cancer xenografts. Clin Cancer Res. 2002;8:986–993
- Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors. Nature. 1999;401:188–193
- Histone deacetylase inhibitor selectively induces p21WAF1 expression and gene-associated histone acetylation. Proc Natl Acad Sci U S A. 2002;97:10014–10019
- Histone deacetylase inhibitors upregulate plakoglobin expression in bladder carcinoma cells and display antineoplastic activity in vitro and in vivo. Int J Cancer. 2005;113:841–848
- Phase I study of an oral histone deacetylase inhibitor, suberoylanilide hydroxamic acid, in patients with advanced cancer. J Clin Oncol. 2005;23:3923–3931
- Phase I clinical trial of histone deacetylase inhibitor: suberoylanilide hydroxamic acid administered intravenously. Clin Cancer Res. 2003;9:3578–3588
- Phase III trial of fluorouracil, interferon alpha-2b, and cisplatin versus methotrexate, vinblastine, doxorubicin, and cisplatin in metastatic or unresectable urothelial cancer. J Clin Oncol. 2002;20:1361–1367
- 5-Fluorouracil and interferon-alpha in chemotherapy refractory bladder carcinoma: An effective regimen. Anticancer Res. 1994;14:1265–1269
- 5-Fluorouracil, interferon-alpha-2b and cisplatin (FAP) for advanced urothelial cancer (A phase II study). Ann Oncol. 1997;8:373–378
- The mechanism of transport of the multitargeted antifolate (MTA) and its cross-resistance pattern in cells with markedly impaired transport of methotrexate. Clin Cancer Res. 2000;6:3687–3695
- A phase I and pharmacokinetic study of LY231514, the multitargeted antifolate. Clin Cancer Res. 1998;4:605–610
- Initial phase I evaluation of the novel thymidylate synthase inhibitor, LY231514, using the modified continual reassessment method for dose escalation. J Clin Oncol. 1995;13:2842–2850
- A phase I evaluation of multitargeted antifolate (MTA, LY231514), administered every 21 days, utilizing the modified continual reassessment method for dose escalation. Cancer Chemother Pharmacol. 1999;44:372–380
- . Phase II study of pemetrexed (PEM) for second-line treatment of transitional cell cancer (TCC) of the bladder. Proc Am Soc Clin Oncol. 2003;22:411;(abstr 1653)
- A phase II trial of pemetrexed plus gemcitabine as first-line treatment for locally advanced or metastatic transitional cell carcinoma of the urothelium. J Clin Oncol. 2005;23(suppl 16):400s;(abstr 4592)
- Neoadjuvant cisplatin chemotherapy before radical cystectomy in invasive transitional cell carcinoma of the bladder: A prospective randomized phase III study. J Urol. 1995;153:964–973
- A comparison of cisplatin and the combination of cisplatin and cyclophosphamide in advanced urothelial cancer (A National Bladder Cancer Collaborative Group A Study). Cancer. 1983;52:767–772
- A randomized trial of cisplatin versus cisplatin plus methotrexate in advanced cancer of the urothelial tract. J Clin Oncol. 1989;7:706–709
- Efficient nucleotide excision repair of cisplatin, oxaliplatin, and Bis-aceto-ammine-dichloro-cyclohexylamine-platinum (IV) (JM216) platinum intrastrand DNA diadducts. Cancer Res. 1999;59:3968–3971
- . In vitro platinum drug chemosensitivity of human cervical squamous cell carcinoma cell lines with intrinsic and acquired resistance to cisplatin. Br J Cancer. 1993;68:240–250
- Phase I and pharmacokinetic study of an oral platinum complex given daily for 5 days in patients with cancer. J Clin Oncol. 1997;15:2691–2700
- Phase I study of oral JM216 given twice daily. Cancer Chemother Pharmacol. 1998;42:142–148
- Phase I clinical and pharmacokinetic study of the oral platinum analogue JM216 given daily for 14 days. Ann Oncol. 1998;9:1315–1322
- Radiopotentiation by the oral platinum agent, JM216: role of repair inhibition. Int J Radiat Oncol Biol Phys. 1999;44:399–405
- Phase II trial of docetaxel in patients with advanced or metastatic transitional-cell carcinoma. J Clin Oncol. 1997;15:1853–1857
- Docetaxel (Taxotere): An active agent in metastatic urothelial cancer; results of a phase II study in non-chemotherapy-pretreated patients. Br J Cancer. 1998;78:1342–1345
- Significant activity of paclitaxel in advanced transitional-cell carcinoma of the urothelium: A phase II trial of the Eastern Cooperative Oncology Group. J Clin Oncol. 1994;12:2264–2270
- Paclitaxel in advanced urothelial carcinoma: Its role in patients with renal insufficiency and as salvage therapy. J Urol. 1996;156:1606–1608
- Paclitaxel and gemcitabine chemotherapy for advanced transitional-cell carcinoma of the urothelial tract: A phase II trial of the Minnie pearl cancer research network. J Clin Oncol. 2001;19:3018–3024
- Epothilones, a new class of microtubule-stabilizing agents with a taxol-like mechanism of action. Cancer Res. 1995;55:2325–2333
- . Activities of the microtubule-stabilizing agents epothilones A and B with purified tubulin and in cells resistant to paclitaxel (Taxol). J Biol Chem. 1997;272:2534–2541
- . Epothilones: Mechanism of action and biologic activity. J Clin Oncol. 2004;22:2015–2025
- BMS-247550: A novel epothilone analog with a mode of action similar to paclitaxel but possessing superior antitumor efficacy. Clin Cancer Res. 2001;7:1429–1437
- Phase I first-in-man study of the epothilone B analog BMS-247550 in patients with advanced cancer. Proc Am Soc Clin Oncol. 2001;20:108;(abstr 428)
- Phase I pharmacokinetic and pharmacodynamic study of an epothilone B analog (BMS-247550) administered as a 1-hour infusion every 3 weeks: An update. J Clin Oncol. 2002;21:103a;(abstr 409)
- Phase I clinical trial of BMS-247550 (epothilone B derivative) in adult patients with advanced solid tumors. J Clin Oncol. 2002;21:102a;(abstr 407)
- Phase I clinical and pharmacology study of the epothilone analog BMS-247550 given weekly in patients (Pts) with advanced solid tumors. J Clin Oncol. 2001;21:108a;(abstr 427)
- Continuous weekly administration of the epothilone-B derivative, BMS247,550 (NSC710428): A phase I and pharmacokinetic (PK) study. J Clin Oncol. 2002;2:103a;(abstr 411)
- Phase I study of the novel epothilone BMS-247550 administered weekly in patients (pts) with advanced malignancies. J Clin Oncol. 2002;21:104a;(abstr 412)
- A phase I clinical trial of BMS-247550 (NSC 71028), an epothilone B derivative, given daily for 3 days on a 21 day cycle in patients with refactory neoplasms. Proc Am Soc Clin Oncol. 2003;22:135;(abstr 540)
- Phase I trial and pharmacokinetic study of BMS-247550, an epothilone B analog, administered intravenously on a daily schedule for five days. J Clin Oncol. 2003;21:1866–1873
- Novel actions of the antitumor drugs vinflunine and vinorelbine on microtubules. Cancer Res. 2000;60:5045–5051
- Antimitotic and tubulin-interacting properties of vinflunine, a novel fluorinated vinca alkaloid. Biochem Pharmacol. 1998;55:635–648
- Superior in vivo experimental antitumour activity of vinflunine, relative to vinorelbine, in a panel of human tumour xenografts. Eur J Cancer. 1999;35:512–520
- A comparison of thermodynamic parameters for vinorelbine- and vinflunine-induced tubulin self-association by sedimentation velocity. Mol Pharmacol. 1998;53:908–915
- Phase I study of Vinflunine administered as a 10-minute infusion on days 1 and 8 every 3 weeks. Invest New Drugs. 2006;24:223–231
- Phase I and pharmacokinetic study of the new vinca alkaloid vinflunine administered as a 10-min infusion every 3 weeks in patients with advanced solid tumours. Ann Oncol. 2003;14:630–637
- The primary antimitotic mechanism of action of the synthetic halichondrin E7389 is suppression of microtubule growth. Mol Cancer Ther. 2005;4:1086–1095
- In vitro and in vivo anticancer activities of synthetic macrocyclic ketone analogues of halichondrin B. Cancer Res. 2001;61:1013–1021
PII: S0093-7754(06)00484-2
doi: 10.1053/j.seminoncol.2006.12.007
© 2007 Elsevier Inc. All rights reserved.
« Previous
Next »
Seminars in Oncology
Volume 34, Issue 2
, Pages 154-164
, April 2007
