Seminars in Oncology
Volume 34, Issue 5 , Pages 379-383, October 2007

Clinically Relevant Biology of Hereditary Breast Cancer

  • William D. Foulkes

      Affiliations

    • Corresponding Author InformationAddress correspondence to William D. Foulkes, MB, PhD, MRCP(UK), Associate Professor, Departments of Medicine, Oncology and Human Genetics, McGill University, 546 Pine Ave W, Montreal, Quebec H2W 156, Canada.

Departments of Medicine, Oncology and Human Genetics, McGill University, Montreal, Quebec, Canada.

published online 28 July 2007.

The identification of the two major breast cancer susceptibility genes BRCA1 and BRCA2 has led to an explosion of work covering the biology and epidemiology of these genes. Clinically, much is known about the risks associated with mutations in these genes, but less is certain with regards to their impact on treatment. This review will touch upon several important aspects of the biology of BRCA1 and BRCA2, but comments regarding these areas will be restricted to those most relevant to the clinician. The three main sections are molecular pathology, DNA repair, and finally other functions of the BRCA1 and BRCA2 proteins.

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PII: S0093-7754(07)00148-0

doi:10.1053/j.seminoncol.2007.07.010

Seminars in Oncology
Volume 34, Issue 5 , Pages 379-383, October 2007

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