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Seminars in Oncology
Volume 34, Issue 6
, Pages 476-490
, December 2007
The Molecular Basis of Melanomagenesis and the Metastatic Phenotype
References
- . The annals of cancer genetics (The description by Norris of hereditary malignant melanoma of the skin in 1820). Cancer Genet Cytogenet. 1989;42:153–156
- Origin of familial melanomas from heritable melanocytic lesions (“The B-K mole syndrome”). Arch Dermatol. 1978;114:732–738
- . Familial atypical multi-mole melanoma syndrome. J Med Genet. 1978;15:352–356
- . Mechanisms of disease: Melanoma. N Engl J Med. 2006;355:51–55
- Assignment of a locus for familial melanoma, MLM, to chromosome 9p13–p22. Science. 1992;258:1148–1152
- Confirmation of chromosome 9p linkage to familial melanoma. Am J Hum Genet. 1993;53:936–942
- Linkage analysis in Dutch familial atypical multiple-mole melanoma (FAMMM) syndrome families (Effect of naevus count). Melanoma Res. 1993;3:271–277
- Linkage of cutaneous malignant melanoma/dysplastic nevi to chromosome 9p, and evidence for genetic heterogeneity. Am J Hum Genet. 1994;54:489–496
- Germline p16 mutations in familial melanoma. Nat Genet. 1994;8:15–21
- Genetic heterogeneity in familial malignant melanoma. Hum Mol Genet. 1994;3:2195–2200
- Analysis of the p16 gene, CDKN2, in 17 Australian melanoma kindreds. Oncogene. 1995;11:2289–2294
- Analysis of the CDK2NA, CDKN2B and CDK4 genes in 48 Australian melanoma kindreds. Oncogene. 1997;15:2999–3005
- Melanomas, from the cell cycle point of view. Int J Mol Med. 1998;1:419–425
- Chromosome 9 deletion in sporadic and familial melanomas in vivo. Oncogene. 1994;9:1649–1653
- Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers. Nature. 1994;268:753–756
- Rarity of somatic and germline mutations of the cyclin-dependent kinase 4 inhibitor gene, CDK4I, in melanoma. Cancer Res. 1994;54:5269–5272
- Deletion mapping of chromosome region 9p21-p22 surrounding the CDKN2 locus in melanoma. Int J Cancer. 1996;65:762–767
- Genetic models of melanoma tumorigenesis based on allelic losses. Genes Chromosomes Cancer. 1995;12:134–141
- Abnormalities in the CDKN2A (p16INK4/MTS-1) gene in human melanoma cells: relevance to tumor growth and metastasis. Oncogene. 1995;11:1399–1402
- Screening of germline mutations in the CDKN2A genes in Swedish families with hereditary utaneous melanoma. J Natl Cancer Inst. 1997;89:697–702
- Role of the cyclin-dependent kinase inhibitor CDKN2A in familial melanoma. J Cutan Med Surg. 1998;2:172–179
- CDKN2A mutations in multiple primary melanomas. N Engl J Med. 1998;338:879–887
- Among genes involved in the RB dependent cell cycle regulatory cascade, the p16 tumor suppressor gene is frequently lost in the Ewing family of tumors. Oncogene. 1997;165:2225–2232
- . Cell cycle control in mammalian cells: Role of cyclins, cyclin dependent kinases (CDK’s), growth suppressor genes and cyclin-dependent kinase inhibitors (CKI’s). Oncogene. 1995;11:211–219
- Germline mutations of the CDKN2 gene in UK melanoma families. Hum Mol Genet. 1997;6:2061–2067
- Melanoma development in relation to non-functional p16/INK4a protein and dysplastic nevus syndrome in Swedish melanoma kindreds. Melanoma Res. 1999;9:21–30
- Genetic alterations of p16INK4a and p53 genes in sporadic dysplastic nevus. Biochem Biophys Res Commun. 1997;237:667–672
- Allelic deletion at chromosome 9p21 (p16) and 17p13 (p53) in microdissected sporadic dysplastic nevus. Hum Pathol. 1998;29:127–130
- Germline CDKN2A mutations in childhood melanoma (letter). J Natl Cancer Inst. 1997;89:1460
- Functional localization of a melanoma tumor suppressor gene to a small (< or = 2 Mb) region on 11q23. Oncogene. 1999;18:3173–3180
- Linkage analysis in familial melanoma kindreds to markers on chromosome 6p. Int J Cancer. 1994;59:771–775
- Two-locus linkage analysis of cutaneous malignant melanoma/dysplastic nevi. Am J Hum Genet. 1996;58:1050–1056
- . Screening of germline mutations in the CDK4, CDKN2C and TP53 genes in familial melanoma: A clinic-based population study. Int J Cancer. 1998;78:13–15
- Incidence of familial melanoma and MLM2 gene. Lancet. 1994;344:1607–1608
- p16 protein expression as an important prognostic factor in primary cutaneous malignant melanoma. Am J Dermatopathol. 1998;20:603;(abstr)
- p16INK4a inactivation is not frequent in uncultured sporadic primary melanoma. Oncogene. 1999;18:2527–2532
- . Chromosome rearrangements in dysplastic nevus syndrome predisposing to malignant melanoma. Cancer Genet Cytogenet. 1998;35:73–78
- Chromosome 9p deletions in cutaneous malignant melanoma tumors: the minimal deleted region involves markers outside the p16 (CDNK2) gene. Am J Hum Genet. 1995;57:395–402
- Loss of heterozygosity in sporadic primary melanoma. Genes Chromosomes Cancer. 1995;12:152–156
- Allelotypes of primary cutaneous melanoma and benign melanocytic nevi. Cancer Res. 1996;56:589–593
- . CDNK2 mutations in melanoma. Cancer Surv. 1995;26:115–132
- Comparison of genetic profiles between primary melanomas and their metastases reveals genetic alterations and clonal evolution during progression. J Invest Dermatol. 1998;111:919–924
- Promotor methylation status of multiple genes in brain metastases of solid tumors. Int J Mol Med. 2004;13:93–98
- p16/cyclin-dependent kinase inhibitor 2A deficiency in human melanocyte senescence, apoptosis, and immortalization: Possible implications for melanoma progression. J Natl Cancer Inst. 2003;95:723–732
- . Melanin accumulation accelerates melanocyte sensescence by a mechanism involving p16INK4a/CDK4/pRB and E2F1. Ann N Y Acad Sci. 2000;908:71–84
- . Epidemiological support for an hypothesis for melanoma induction indication of a role for UVA radiation. Photochem Photobiol. 1999;70:243–247
- Biallelic mutations in p16(INK4a) confer resistance to Ras- and Ets-induced senescence in human diploid fibroblasts. Mol Cell Biol. 2002;22:8135–8143
- . bcl-2 protein expression in cutaneous malignant melanoma and benign melanocytic nevi. Am J Dermatopathol. 1995;17:7–11
- . Bcl-2 expression in melanocytic nevi. Arch Dermatol. 1995;131:915–918
- . Bcl-2 protein expression in melanocytic neoplasms of the skin. Mod Pathol. 1995;8:150–154
- Immunohistochemical expression of BCL-2 in melanomas and intradermal nevi. J Cutan Pathol. 1994;21:393–397
- Differential expression of bcl-2 oncogene in human basal cell carcinoma. Hum Pathol. 1996;27:355–359
- Expression of p21WAF1/CIP1 in aggressive- versus non-aggressive-growth basal cell carcinoma: A comparative study. Lab Invest. 1999;79:56A;(abstr)
- Microsatellite instability and loss of heterozygosity in melanoma. J Invest Dermatol. 1995;105:625–628
- Classifying melanocytic tumors based on DNA copy number changes. Am J Pathol. 2003;163:1765–1770
- CD95/Fas signaling in human melanoma cells: Conditional expression of CD95L/FasL overcomes the intrinsic apoptosis resistance of malignant melanoma and inhibits growth and progression of human melanoma xenotransplants. Oncogene. 2003;22:9131–9141
- Effect of endogenous interleukin-6 on Fas (APO-1/CD95) receptor expression in advanced melanoma patients. Cytokines Cell Mol Ther. 2000;6:135–140
- Interferon-gamma and anti-Fas antibody-induced apoptosis in human melanoma cell lines and its relationship to bcl-2 cleavage. Melanoma Res. 2003;13:153–159
- Inhibition of growth of melanoma cells by CD95 (Fas/APO-1) gene transfer in vivo. J Invest Dermatol. 2000;115:1008–1014
- . Plasma Fas ligand, an inducer of apoptosis, and plasma soluble Fas, an inhibitor of apoptosis, in advanced melanoma. Melanoma Res. 2000;10:461–467
- Differential increase of Fas ligand expression on metastatic and thin or thick primary melanoma cells compared with interleukin-10. Melanoma Res. 1999;9:261–272
- A comparative study of Fas and Fas-ligand expression during melanoma progression. Br J Dermatol. 2000;143:307–312
- Suppression of telomerase activity as an indicator of drug-induced cytotoxicity against cancer cells: In vitro studies with fresh human tumor samples. Lab Invest. 1999;79:993–1005
- Up-regulation of human telomerase catalytic subunit during gastric carcinogenesis. Cancer. 1999;86:559–565
- Human chromosome 5 carries a putative telomerase repressor gene. Genes Chromosomes Cancer. 2003;36:37–47
- Detection of telomerase RNA in the plasma of patients with breast cancer, malignant melanoma or thyroid cancer. Oncol Rep. 2004;11:245–252
- Increased expression of apoptoic markes in melanoma. Melanoma Res. 2003;13:137–145
- Telomerase activity in melanocytic lesions: A potential marker of tumor biology. Am J Pathol. 2000;156:1425–1432
- Induction of Hsp90 protein expression in malignant melanomas and melanoma metastases. Exp Dermatol. 2004;13:27–32
- . Uncapping and deregulation of telomeres lead to detrimental consequences in yeast. J Cell Biol. 1999;145:203–214
- Ancient melanocytic nevus. Semin Diagn Pathol. 1998;15:210–215
- Identification of a </=600-kb region on human chromosome 1q42.3 inducing cellular senescence. Oncogene. 2003;22:281–290
- Human telomerase reverse transcriptase-transduced human cytotoxic T-cells suppress the growth of human melanoma in immunodeficient mice. Cancer Res. 2004;64:2153–2161
- Distinct sets of genetic alterations in melanoma. New Engl J Med. 2005;353:2104–2107
- Somatic activation of KIT in distinctive subtypes of melanoma. J Clin Oncol. 2006;24:4340–4346
- . Protein tyrosine kinases in malignant melanoma. Melanoma Res. 2000;10:401–411
- . VEGF signalling in tumor angiogenesis. Oncologist. 2000;5(suppl 1):3–10
- Regulation of Fas-mediated apoptosis by N-ras in melanomas. J Invest Dermatol. 2002;119:556–561
- Induction of different morphological features of malignant melanoma and pigmented lesions after transformation of murine melanocytes with bFGF-cDNA and H-ras, myc, neu and E1a oncogenes. Am J Pathol. 1991;138:349–358
- Prognostic classification of malignant melanoma by combining clinical, histological, and immunohistochemical parameters. Oncology. 1999;56:208–214
- Measurement of c-myc oncogene expression provides an accurate prognostic marker for acral lentiginous melanoma. Br J Plast Surg. 1999;52:122–126
- Use of oncogene expression as an independent prognostic marker for primary melanoma. Ann Plast Surg. 2003;50:183–187
- . Apoptosis and melanoma: Molecular mechansisms. J Pathol. 2003;199:275–288
- Inhibition of c-Myc oncoprotein limits the growth of human melanoma cells by inducing cellular crisis. J Biol Chem. 2003;278:35693–35701
- Targeted liposomal c-myc antisense oligodeoxynucleotides induce apoptosis and inhibit tumor growth and metastases in human melanoma models. Clin Cancer Res. 2003;9:4594–4605
- C-Myc is able to sensitize human melanoma cells to diverse apoptotic triggers. Melanoma Res. 2004;14:3–12
- Expression of c-myc and bcl-2 in primary and advanced cutaneous melanoma. Cancer Invest. 2002;20:914–921
- Gene expression profiling of melanocytic tumors. Am J Dermatopathol. 2003;25:6–11
- Comparative genomic hybridization for molecular cytogenetic analysis of solid tumors. Science. 1992;258:818–821
- High resolution analysis of DNA copy number variation using comparative genomic hybridization to microarrays. Nat Genet. 1998;20:207–211
- Assembly of microarrays for genome-wide measurement of DNA copy number. Nat Genet. 2001;29:263–264
- Quantitative mapping of amplicon structure by array CGH identified CYP24 as a candidate oncogene. Nat Genet. 2000;25:144–146
- A tiling resolution DNA microarray with complete coverage of the human genome. Nat Genet. 2004;36:299–303
- Chromosomal gains and losses in primary cutaneous melanomas detected by comparative genomic hybridization. Cancer Res. 1998;58:2170–2175
- Gene amplifications characterize acral melanomas and permit the detection of occult tumor cells in the surrounding skin. Cancer Res. 2000;60:1968–1973
- Cyclin D1 is a candidate oncogene in cutaneous melanoma. Cancer Res. 2002;62:3200–3206
- Molecular cytogenetic analysis of Spitz nevi shows clear differences to melanoma. J Invest Dermatol. 1999;113:1065–1069
- Evaluation of DNA ploidy in dysplastic and Spitz nevi by flow cytometry. J Cutan Pathol. 1990;17:342–347
- . Persistent (recurrent) Spitz nevi: A histopathologic, immunohistochemical, and molecular pathologic study of 22 cases. Am J Surg Pathol. 2002;26:654–661
- Mechanisms of cell-cycle arrest in Spitz nevi with constitutive activation of the MAP-kinase pathway. Am J Pathol. 2004;164:1783–1787
- Inhibition of tumor endothelial ERK activation, angiogenesis, and tumor growth by sorafenib (BAY 43-9006). Am J Pathol. 2006;169:1875–1885
- Role of Raf kinase in cancer: Therapeutic potential of targeting the Raf/MEK/ERK signal transduction pathway. Semin Oncol. 2006;33:392–406
- MIB-1 proliferative activity is a significant prognostic factor in primary thick cutaneous melanomas. J Invest Dermatol. 1995;105:22–26
- Prognostic significance of MIB-1 proliferative activity in thin melanomas and immunohistochemical analysis of MIB-1 proliferative activity in melanocytic tumors. Am J Dermatopathol. 1998;20:12–16
- . The Melanocytic Proliferations: A Comprehensive Textbook of Pigmented Lesions. New York, NY: Wiley; 2001;
- Expression of proliferating cell nuclear antigen in Spitz nevus. J Am Acad Dermatol. 1995;32:964–967
- Proliferating cell nuclear antigen (PCNA) and recurrence in patients with cutaneous melanoma. Melanoma Res. 1994;4:207–211
- Correlation of Ki-67 and PCNA to DNA ploidy, S-phase fraction and survival in uveal melanoma. Eur J Cancer. 1996;32A:357–362
- Prognostic evaluation of cutaneous malignant melanoma: A clinicopathological and immunohistochemical study. J Surg Oncol. 1999;70:150–160
- Tumor characteristics involved in the metastatic behaviour as an improvement in primary cutaneous melanoma prognostics. J Exp Clin Cancer Res. 1998;17:483–489
- Cell proliferation markers in predicting metastases in malignant melanoma. J Cutan Pathol. 1995;22:248–251
- Mitotic rate and S-phase fraction as prognostic factors in stage I cutaneous malignant melanoma. Br J Cancer. 1998;77:1917–1925
- . Prognosticators of melanoma and the sentinel lymph node. Mod Pathol. 2006;19:S71–S87
- A new American Joint Committee on Cancer staging system for cutaneous melanoma. Cancer. 2000;88:1484–1491
- . Prediction of outcome for patients with cutaneous melanoma. Pigment Cell Res. 1997;10:162–167
- E-cadherin expression in melanoma cells restores keratinocyte-mediated growth control and down-regulates expression of invasion-associated adhesion receptors. Am J Pathol. 2000;156:1515–1525
- . Role of growth factors and their receptors in the development and progression of melanoma. J Invest Dermatol. 1993;100(suppl):196S–203S
- Basic fibroblast growth factor production and growth factor receptors as potential targets for melanoma therapy. Melanoma Res. 1992;2:13–23
- . Differential expression of epidermal growth factor receptor in melanocytic tumours demonstrated by immunohistochemistry and mRNA in situ hybridization. Australas J Dermatol. 1999;40:19–24
- Immunohistochemical evidence of cytokine networks during progression of human melanocytic lesions. Int J Cancer. 1999;84:160–168
- . Independent regulation of growth and SMAD-mediated transcription by transforming growth factor beta in human melanoma cells. Cancer Res. 1999;59:547–550
- Dominant-negative CREB inhibits tumor growth and metastasis of human melanoma cells. Oncogene. 1997;15:2069–2075
- Expression of transforming growth factor-beta 2 in malignant melanoma correlates with depth of tumor invasion (Implications for tumor progression). Am J Pathol. 1994;145:97–104
- Cell surface CD44-related chondroitin sulfate proteoglycan is required for transforming growth factor-stimulated mouse melanoma cell motility and invasive behaviour on type I collagen. J Cell Sci. 1993;106:501–511
- Progression-related expression of β3 integrin in melanomas and nevi. Hum Pathol. 1999;33:562–567
- Molecular prognostic markers in intermediate-thickness cutaneous malignant melanoma. Cancer. 1999;85:375–382
- Beta3 integrin expression in melanoma predicts subsequent metastasis. J Surg Res. 1996;63:169–173
- Beta 1 integrin expression: A marker of lymphatic metastases in cutaneous malignant melanoma. Anticancer Res. 1996;16:2321–2324
- In situ expression of transforming growth factor beta is associated with melanoma progression and correlates with Ki67, HLA-DR and beta 3 integrin expression. Melanoma Res. 1997;7:313–321
- Up-regulated expression of the beta3 integrin and the 92kDa gelatinase in human HT-144 melanoma cell tumors grown in nude mice. Int J Cancer. 1996;68:650–662
- New functions for non-collagenous domains of human collagen type IV (Novel integrin ligands inhibiting angiogenesis and tumor growth in vivo). J Biol Chem. 2000;275:8051–8061
- Regulation of tumor cell chemtoaxis by type IV collagen is mediated by a Ca(2+)-dependent mechanism requiring CD47 and the integrin alpha(v)beta(3). J Biol Chem. 2000;275:4796–4802
- The inetgrins alpha 3 beta 1 and alpha 6 beta 1 physically and functionally associate with CD36 in human melanoma cells. J Biol Chem. 2000;275:35264–35275
- The biology of melanoma brain metastasis. Cancer Metastasis Rev. 1999;18:387–400
- Expression of integrin alpha(v)beta(3) correlates with activation of membrane-type matrix metalloproteinase-1 (MT1-MMP) and matrix metalloproteinase-2 (MMP-2) in human melanoma cells in vitro and in vivo. Int J Cancer. 2000;87:12–19
- Alpha(v)beta3 expression on blood vessels and melanoma cells in primary lesions: Differential association with tumor progression and clinical prognosis. Cancer Immunol Immunother. 2000;49:314–318
- . Molecular role(s) for integrins in human melanoma invasion. Cancer Metastasis Rev. 1999;18:359–375
- Contact with fibrillar collagen inhibits melanoma cell proliferation by up-regulating p27KIP1. Proc Natl Acad Sci U S A. 2000;97:10026–10031
- Expression of integrin alpha5beta1 and MMPs associated with epithelioid cytomorphology and malignancy of uveal melanoma. Invest Ophthalmol Vis Sci. 2000;41:2363–2372
- Prognostic value of beta1 integrin expression in metastatic melanoma. Melanoma Res. 2000;10:243–251
- . Isolation and characterization of human melanoma cell variants expressing high and low levels of CD44. Cancer Res. 1991;51:6660–6667
- CD44 expression in benign and malignant nevomelanocytic lesions. Hum Pathol. 1996;27:1288–1294
- CD44 and variants in melanocytic skin neoplasms. J Cutan Pathol. 1998;25:199–203
- Moesin and CD44 expression in cutaneous melanocytic tumours. Br J Dermatol. 1998;138:763–768
- Osteonectin expression correlates with clinical outcome in thin cutaneous malignant melanomas. Hum Pathol. 1999;30:339–344
- . Assignment of the human melanoma cell adhesion molecule gene (MCAM) to chromosome 11 band q23.3 by radiation hybrid mapping. Cytogenet Cell Genet. 1999;87:258
- Melanoma cell-cell interactions are mediated through heterophile Mel-CAM/ligand interaction. Cancer Res. 1997;57:3835–3840
- . Identification of the elements regulating the expression of the cell adhesion molecule MCAM/MUC18. J Biol Chem. 2000;275:34672–34680
- Expression of MCAM/MUC 18 by human melanoma cells leads to increased tumor growth and metastasis. Cancer Res. 1997;57:2295–2303
- . The role of CD146 (Mel-CAM) in biology and pathology. J Pathol. 1999;189:4–11
- . Regulation of tumor growth and metastasis of human melanoma by the CREB transcription factor family. Mol Cell Biochem. 2000;212:19–28
- CREB and its associated proteins act as survival factors for human melanoma cells. J Biol Chem. 1998;273:24884–24890
- ATF2 confers radiation resistance to human melanoma cells. Oncogene. 1998;16:523–531
- Expression of desmoglein I and plakoglobin in skin carcinomas. J Cutan Pathol. 2000;27:24–29
- . Actin-rich desmoplastic malignant melanoma. Am J Dermatopathol. 1999;21:537–541
- . Actin-binding protein requirement for cortical stability and efficient locomotion. Science. 1992;255:325–327
- Expression of cytoskeletal components in melanocytic skin lesions (An immunohistochemical study). Am J Dermatopathol. 1991;13:137–144
- Alpha-smooth muscle actin expression in tumor and stromal cells of benign and malignant human pigment tumors. J Invest Dermatol. 1992;98:116–120
- . A variant actin (beta m) reduces metastases of mouse B16 melanoma. Int J Cancer. 1994;56:689–697
- Experimental coexpression of vimentin and keratin intermediate filaments in human melanoma cells augments motility. Am J Pathol. 1996;148:63–69
- In situ distribution of integrin alpha 2 beta 1 and alpha-actinin in melanocytic proliferations. Mod Pathol. 1996;9:938–943
- Actin-binding protein expression in benign and malignant melanocytic proliferations. Hum Pathol. 1994;25:709–714
- Actin organization and cell migration of melanoma cells relate to differential expression of integrins and actin-associated proteins. J Dermatol. 1992;19:847–852
- Interrelation of motility, cytoskeletal organization and gap junctional communication with invasiveness of melanocytic cells in vitro. Invasion Metastasis. 1997;17:26–41
- . Positive attachment between cytoskeletal changes, melanoma cell attachment and invasion in vitro. Melanoma Res. 1998;8:303–311
- Cell shape changes and cytoskelton reorganization during transmigration of human melanoma cells. Cell Tissue Res. 1998;293:375–387
- Physical and functional interaction of filamin (actin-binding protein 280) and tumor necrosis factor receptor-associated factor 2. J Biol Chem. 2000;2745:271–278
- Prognostic value of MMP-2 immunoreactive protein (72kD type IV collagenase) in primary skin melanoma. J Pathol. 1998;186:51–58
- . [Involvement of matrix metalloproteinases (MMPs) in cutaneous melanoma progression]. Pathol Biol (Paris). 2004;52:154–159
- Expression of collagenases-1 and −3 and their inhibitors TIMP-1 and −3 correlates with the level of invasion in malignant melanomas. Br J Cancer. 1999;80:733–743
- Membrane type-1 matrix metalloproteinase promotes human melanoma invasion and growth. J Invest Dermatol. 2004;122:167–176
- Melanoma invasion in reconstructed human skin is influenced by skin cells—Investigation of the role of proteolytic enzymes. Clin Exp Metastasis. 2003;20:685–700
- . Influence of cultured dermal fibroblasts on human melanoma cell proliferation, matrix metalloproteinase-2 (MMP-2) expression and invasion in vitro. Arch Dermatol Res. 2003;295:236–241
- Transforming growth factor-beta 1 inhibits tumor growth in a mouse model by down-regulating the plasminogen activation system. Exp Cell Res. 2003;291:1–10
- Expression of cathepsin D in primary and metastatic melanoma and dysplastic nevi. J Invest Dermatol. 1995;104:340–344
- The ‘Abtropfung phenonmenon’ revisited: Dermal nevus cells from congenital nevi cannot activiate matrix metalloproteinase 2 (MMP-2). Pigment Cell Res. 2003;16:366–373
- The matrix metalloproteinase inhibitor batimastat inhibits angiogenesis in liver metastases of B16F1 melanoma cells. Clin Exp Metastasis. 1999;17:111–117
- . Tissue inhibitors of metalloproteinase (TIMP) in invasion and proliferation. APMIS. 1999;107:111–119
- Inhibition of invasion and induction of cell death of cancer cell lines by overexpression of TIMP-3. Br J Cancer. 1999;79:1347–1355
- Tissue inhibitor of metalloproteinase-3 induces apoptosis in melanoma cells by stabilization of death receptors. Oncogene. 2003;22:2121–2134
- Treatment of lentigo maligna with topical imiquimod. Br J Dermatol. 2003;149(suppl 66):66–69
- In vivo and in situ modulation of the expression of genes involved in metastasis and angiogenesis in a patient treated with topical imiquimod for melanoma skin metastases. Br J Dermatol. 2004;150:761–767
- Evidence that the p75 neurotrophin receptor mediates perineural spread of desmoplastic melanoma. J Am Acad Dermatol. 1996;35:725–731
- p75 neurotrophin receptor functions as a survival receptor in brain-metastastic melanoma cells. J Cell Biochem. 2004;91:206–215
- . Differential expression of basic fibroblastic growth factor (bFGF) in melanocytic lesions demonstrated by in situ hybridization (Implications for tumor progression). Am J Pathol. 1994;144:329–336
- Basic fibroblast growth factor induces a transformed phenotype in normal human melanocytes. Oncogene. 1999;18:6469–6476
- Human melanoma progression in skin reconstructs: biological significance of bFGF. Am J Pathol. 2000;156:193–200
- Lentigo maligna and superficial spreading melanoma are different in their in situ phase: An immunohistochemical study. Hum Pathol. 2002;33:1001–1005
- . Heterogeneity of cytokine and growth factor gene expression in human melanoma cells with metastatic potentials. J Interferon Cytokine Res. 1995;15:81–87
- . VEGF, bFGF and EGF in the angiogenesis of human melanoma xenografts. Int J Cancer. 1998;76:836–841
- Neovascularization, expression of fibroblast growth factor-2 and mast cells with tryptase activity increase simultaneously with pathological expression in human malignant melanoma. Eur J Cancer. 2003;39:666–674
- Expression of the mast cell growth factor interleukin-3 in melanocytic lesions correlates with an increased number of mast cells in the perilesional stroma: implications for melanoma progression. J Cutan Pathol. 1996;23:495–505
- Expression of basic fibroblast growth factor in desmoplastic melanoma. J Cutan Pathol. 1996;23:118–125
- . The desmoplastic response: Induction of collagen synthesis by melanoma cells in vitro. Int J Cancer. 1992;50:621–627
- Ultrastructural observations concerning laminin in B16 melanoma (Is an amorphous form of laminin promoting a non hematogenous migration of tumor cells?). J Submicrosc Cytol Pathol. 1998;30:137–144
- Angio-tumoral laminin in murine tumors derived from human melanoma cell lines (Immunohistochemical and ultrastructural observations). J Submicrosc Cytol Pathol. 1998;30:231–237
- Ultrastructural and immunohistochemical studies of the periendothelial matrix in human melanoma: Evidence for an amorphous matrix containing laminin. J Cutan Pathol. 1999;26:78–83
- Tumor microvessels in melanoma express the beta-2 chain of laminin (Implications for melanoma metastases). J Cutan Pathol. 1999;26:222–226
PII: S0093-7754(07)00177-7
doi: 10.1053/j.seminoncol.2007.09.007
© 2007 Elsevier Inc. All rights reserved.
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Seminars in Oncology
Volume 34, Issue 6
, Pages 476-490
, December 2007
