Seminars in Oncology
Volume 34, Issue 6 , Pages 460-466 , December 2007

Melanoma: Prevention and Early Detection

  • Jeremy S. Bordeaux

      Affiliations

    • Department of Dermatology, Case Western Reserve University, Cleveland, OH.
    • Multidisciplinary Melanoma Program, Ireland Cancer Center, University Hospitals Case Medical Center, Cleveland, OH.
    • J.S.B. and K.Q.L. contributed equally to this work.
  • ,
  • Kurt Q. Lu

      Affiliations

    • Department of Dermatology, Case Western Reserve University, Cleveland, OH.
    • J.S.B. and K.Q.L. contributed equally to this work.
  • ,
  • Kevin D. Cooper

      Affiliations

    • Department of Dermatology, Case Western Reserve University, Cleveland, OH.
    • Multidisciplinary Melanoma Program, Ireland Cancer Center, University Hospitals Case Medical Center, Cleveland, OH.
    • Veterans Affairs Medical Center, Cleveland, OH.
    • Corresponding Author InformationAddress correspondence to Kevin D. Cooper, MD, University Hospitals of Cleveland, 11100 Euclid Ave, Lakeside 3516, Cleveland, OH 44106.

References 

  1. Lens MB, Dawes M. Global perspectives of contemporary epidemiological trends of cutaneous malignant melanoma. Br J Dermatol. 2004;150:179–185
  2. Cancer Facts and Figures. American Cancer Society; 2007;
  3. Melanoma Fact Sheet. American Academy of Dermatology; 2007;
  4. Balch CM, Soong SJ, Gershenwald JE, et al. Prognostic factors analysis of 17,600 melanoma patients: Validation of the American Joint Committee on Cancer melanoma staging system. J Clin Oncol. 2001;19:3622–3634
  5. Saraiya M, Glanz K, Briss P, et al. Preventing skin cancer: Findings of the Task Force on Community Preventive Services on Reducing Exposure to Ultraviolet Light. MMWR. 2003;52:1–12
  6. Armstrong BK, Kricker A. How much melanoma is caused by sun exposure?. Melanoma Res. 1993;3:395–401
  7. Khlat M, Vail A, Parkin M, et al. Mortality from melanoma in migrants to Australia: Variation by age at arrival and duration of stay. Am J Epidemiol. 1992;135:1103–1113
  8. Wei Q, Lee JE, Gershenwald JE, et al. Repair of UV light-induced DNA damage and risk of cutaneous malignant melanoma. J Natl Cancer Inst. 2003;95:308–315
  9. Kricker A, Armstrong BK, Goumas C, et al. Ambient UV, personal sun exposure and risk of multiple primary melanomas. Cancer Causes Control. 2007;18:295–304
  10. Elwood JM, Gallagher RP. Body site distribution of cutaneous malignant melanoma in relationship to patterns of sun exposure. Int J Cancer. 1998;78:276–280
  11. Elwood JM, Jopson J. Melanoma and sun exposure: An overview of published studies. Int J Cancer. 1997;73:198–203
  12. Nelemans PJ, Rampen FH, Ruiter DJ, et al. An addition to the controversy on sunlight exposure and melanoma risk: A meta-analytical approach. J Clin Epidemiol. 1995;48:1331–1342
  13. Giles GG, Armstrong BK, Burton RC, et al. Has mortality from melanoma stopped rising in Australia? (Analysis of trends between 1931 and 1994). BMJ. 1996;312:1121–1125
  14. Glanz K, Saraiya M, Wechsler H. Guidelines for school programs to prevent skin cancer. MMWR. 2002;51:1–18
  15. Lim HW, Cooper K. The health impact of solar radiation and prevention strategies: Report of the Environment Council, American Academy of Dermatology. J Am Acad Dermatol. 1999;41:81–99
  16. Year-Round Sun Protection. Skin Cancer Foundation; 2007;
  17. Skin Cancer Prevention and Early Detection. American Cancer Society; 2007;
  18. Geller AC, Cantor M, Miller DR, et al. The Environmental Protection Agency’s National SunWise School Program: Sun protection education in US schools (1999-2000). J Am Acad Dermatol. 2002;46:683–689
  19. Westerdahl J, Olsson H, Masback A, et al. Is the use of sunscreens a risk factor for malignant melanoma?. Melanoma Res. 1995;5:59–65
  20. Elwood JM, Gallagher RP. More about: Sunscreen use, wearing clothes, and number of nevi in 6- to 7-year-old European children. J Natl Cancer Inst. 1999;91:1164–1166
  21. Autier P, Dore JF, Schifflers E, et al. Melanoma and use of sunscreens: An EORTC case-control study in Germany, Belgium and France (The EORTC Melanoma Cooperative Group). Int J Cancer. 1995;61:749–755
  22. Weinstock MA. Do sunscreens increase or decrease melanoma risk: An epidemiologic evaluation. J Invest Dermatol Symp Proc. 1999;4:97–100
  23. Holman CD, Armstrong BK, Heenan PJ. Relationship of cutaneous malignant melanoma to individual sunlight-exposure habits. J Natl Cancer Inst. 1986;76:403–414
  24. Cartwright LE, Walter JF. Psoralen-containing sunscreen is tumorigenic in hairless mice. J Am Acad Dermatol. 1983;8:830–836
  25. Ashwood-Smith MJ, Poulton GA, Barker M, et al. 5-Methoxypsoralen, an ingredient in several suntan preparations, has lethal, mutagenic and clastogenic properties. Nature. 1980;285:407–409
  26. Autier P. The role of sunscreens in melanoma prevention. In:  Thompson JF,  Kroon B editor. Textbook of Melanoma. Vol 1:London: Martin Dunitz; 2004;p. 90;aD, JF
  27. Autier P, Dore JF, Negrier S, et al. Sunscreen use and duration of sun exposure: A double-blind, randomized trial. J Natl Cancer Inst. 1999;91:1304–1309
  28. Autier P, Dore JF, Reis AC, et al. Sunscreen use and intentional exposure to ultraviolet A and B radiation: A double blind randomized trial using personal dosimeters. Br J Cancer. 2000;83:1243–1248
  29. Geller AC, Colditz G, Oliveria S, et al. Use of sunscreen, sunburning rates, and tanning bed use among more than 10 000 US children and adolescents. Pediatrics. 2002;109:1009–1014
  30. Davis KJ, Cokkinides VE, Weinstock MA, et al. Summer sunburn and sun exposure among US youths ages 11 to 18: National prevalence and associated factors. Pediatrics. 2002;110:27–35
  31. Gallagher RP, Hill GB, Bajdik CD, et al. Sunlight exposure, pigmentation factors, and risk of nonmelanocytic skin cancer (II. Squamous cell carcinoma). Arch Dermatol. 1995;131:164–169
  32. Gallagher RP, Hill GB, Bajdik CD, et al. Sunlight exposure, pigmentary factors, and risk of nonmelanocytic skin cancer (I. Basal cell carcinoma). Arch Dermatol. 1995;131:157–163
  33. Whiteman DC, Whiteman CA, Green AC. Childhood sun exposure as a risk factor for melanoma: A systematic review of epidemiologic studies. Cancer Causes Control. 2001;12:69–82
  34. Cokkinides V, Weinstock M, Glanz K, et al. Trends in sunburns, sun protection practices, and attitudes toward sun exposure protection and tanning among US adolescents, 1998-2004. Pediatrics. 2006;118:853–864
  35. Westerdahl J, Ingvar C, Masback A, et al. Risk of cutaneous malignant melanoma in relation to use of sunbeds: Further evidence for UV-A carcinogenicity. Br J Cancer. 2000;82:1593–1599
  36. Magee KH, Poorsattar S, Seidel KD, et al. Tanning device usage: What are parents thinking?. Pediatr Dermatol. 2007;24:216–221
  37. Dellavalle RP, Parker ER, Cersonsky N, et al. Youth access laws: In the dark at the tanning parlor?. Arch Dermatol. 2003;139:443–448
  38. Knight JM, Kirincich AN, Farmer ER, et al. Awareness of the risks of tanning lamps does not influence behavior among college students. Arch Dermatol. 2002;138:1311–1315
  39. Robinson JK, Rigel DS, Amonette RA. Trends in sun exposure knowledge, attitudes, and behaviors: 1986 to 1996. J Am Acad Dermatol. 1997;37:179–186
  40. Levins PC, Carr DB, Fisher JE, et al. Plasma beta-endorphin and beta-lipoprotein response to ultraviolet radiation. Lancet. 1983;2:166
  41. Kaur M, Liguori A, Lang W, et al. Induction of withdrawal-like symptoms in a small randomized, controlled trial of opioid blockade in frequent tanners. J Am Acad Dermatol. 2006;54:709–711
  42. Warthan MM, Uchida T, Wagner RF. UV light tanning as a type of substance-related disorder. Arch Dermatol. 2005;141:963–966
  43. Poorsattar SP, Hornung RL. UV light abuse and high-risk tanning behavior among undergraduate college students. J Am Acad Dermatol. 2007;56:375–379
  44. Tanning Restrictions for Minors, A State-by-State Comparison. National Conference of State Legislatures; 2007;August 22
  45. Epstein DS, Lange JR, Gruber SB, et al. Is physician detection associated with thinner melanomas?. JAMA. 1999;281:640–643
  46. McPherson M, Elwood M, English DR, et al. Presentation and detection of invasive melanoma in a high-risk population. J Am Acad Dermatol. 2006;54:783–792
  47. Grin CM, Kopf AW, Welkovich B, et al. Accuracy in the clinical diagnosis of malignant melanoma. Arch Dermatol. 1990;126:763–766
  48. Chen SC, Pennie ML, Kolm P, et al. Diagnosing and managing cutaneous pigmented lesions: Primary care physicians versus dermatologists. J Gen Intern Med. 2006;21:678–682
  49. Geller AC, Koh HK, Miller DR, et al. Use of health services before the diagnosis of melanoma: Implications for early detection and screening. J Gen Intern Med. 1992;7:154–157
  50. Cassileth BR, Clark WH, Lusk EJ, et al. How well do physicians recognize melanoma and other problem lesions?. J Am Acad Dermatol. 1986;14:555–560
  51. Kittler H, Pehamberger H, Wolff K, et al. Diagnostic accuracy of dermoscopy. Lancet Oncol. 2002;3:159–165
  52. Carli P, de Giorgi V, Chiarugi A, et al. Addition of dermoscopy to conventional naked-eye examination in melanoma screening: A randomized study. J Am Acad Dermatol. 2004;50:683–689
  53. Argenziano G, Puig S, Zalaudek I, et al. Dermoscopy improves accuracy of primary care physicians to triage lesions suggestive of skin cancer. J Clin Oncol. 2006;24:1877–1882
  54. Westerhoff K, McCarthy WH, Menzies SW. Increase in the sensitivity for melanoma diagnosis by primary care physicians using skin surface microscopy. Br J Dermatol. 2000;143:1016–1020
  55. Tripp JM, Kopf AW, Marghoob AA, et al. Management of dysplastic nevi: A survey of fellows of the American Academy of Dermatology. J Am Acad Dermatol. 2002;46:674–682
  56. Lucas CR, Sanders LL, Murray JC, et al. Early melanoma detection: Nonuniform dermoscopic features and growth. J Am Acad Dermatol. 2003;48:663–671
  57. Feit NE, Dusza SW, Marghoob AA. Melanomas detected with the aid of total cutaneous photography. Br J Dermatol. 2004;150:706–714
  58. Aitken JF, Janda M, Elwood M, et al. Clinical outcomes from skin screening clinics within a community-based melanoma screening program. J Am Acad Dermatol. 2006;54:105–114
  59. Ubel PA, Hirth RA, Chernew ME, et al. What is the price of life and why doesn’t it increase at the rate of inflation?. Arch Intern Med. 2003;163:1637–1641
  60. Freedberg KA, Geller AC, Miller DR, et al. Screening for malignant melanoma: A cost-effectiveness analysis. J Am Acad Dermatol. 1999;41:738–745
  61. Girgis A, Clarke P, Burton RC, et al. Screening for melanoma by primary health care physicians: A cost-effectiveness analysis. J Med Screen. 1996;3:47–53
  62. Losina E, Walensky RP, Geller A, et al. Visual screening for malignant melanoma: A cost-effectiveness analysis. Arch Dermatol. 2007;143:21–28
  63. Screening for Skin Cancer. US Preventive Services Task Force; 2007;
  64. Screening for Cervical Cancer. US Preventive Services Task Force; 2007;
  65. Screening for Colorectal Cancer. US Preventive Services Task Force; 2007;
  66. Koh HK. Melanoma screening: Focusing the public health journey. Arch Dermatol. 2007;143:101–103
  67. Berwick M, Begg CB, Fine JA, et al. Screening for cutaneous melanoma by skin self-examination. J Natl Cancer Inst. 1996;88:17–23
  68. DiFronzo LA, Wanek LA, Morton DL. Earlier diagnosis of second primary melanoma confirms the benefits of patient education and routine postoperative follow-up. Cancer. 2001;91:1520–1524
  69. Robinson JK, Turrisi R, Stapleton J. Efficacy of a partner assistance intervention designed to increase skin self-examination performance. Arch Dermatol. 2007;143:37–41
  70. Marks R. Campaigning for melanoma prevention: A model for a health education program. J Eur Acad Dermatol Venereol. 2004;18:44–47
  71. Li C, Liu Z, Zhang Z, et al. Genetic variants of the vitamin D receptor gene alter risk of cutaneous melanoma. J Invest Dermatol. 2007;127:276–280
  72. Setlow RB. Spectral regions contributing to melanoma: A personal view. J Invest Dermatol Symp Proc. 1999;4:46–49
  73. Freeman SR, Drake AL, Heilig LF, et al. Statins, fibrates, and melanoma risk: A systematic review and meta-analysis. J Natl Cancer Inst. 2006;98:1538–1546

PII: S0093-7754(07)00187-X

doi: 10.1053/j.seminoncol.2007.09.012

Seminars in Oncology
Volume 34, Issue 6 , Pages 460-466 , December 2007