« Previous
Next »
Seminars in Oncology
Volume 35
, Pages S22-S30
, April 2008
Clinical Studies With Epothilones for the Treatment of Metastatic Breast Cancer
References
- Chemotherapy of metastatic breast cancer: What to expect in 2001 and beyond. Oncologist. 2001;6:133–146
- . Mechanisms and strategies to overcome multiple drug resistance in cancer. FEBS Lett. 2006;580:2903–2909
- . Mechanisms of multidrug resistance: The potential role of microtubule-stabilizing agents. Ann Oncol. 2007;18(suppl 5):v3–v8
- Desoxyepothilone B: An efficacious microtubule-targeted antitumor agent with a promising in vivo profile relative to epothilone B. Proc Natl Acad Sci U S A. 1998;95:9642–9647
- BMS-247550: A novel epothilone analog with a mode of action similar to paclitaxel but possessing superior antitumor efficacy. Clin Cancer Res. 2001;7:1429–1437
- Vahdat L: Ixabepilone: A novel antineoplastic agent with low susceptibility to multiple tumor resistance mechanisms. Oncologist (in press)
- . Ixabepilone, first in a new class of antineoplastic agents: The natural epothilones and their analogues. Clin Breast Cancer. 2007;7:757–763
- . Targeting the microtubules in breast cancer beyond taxanes: The epothilones. Oncologist. 2007;12:271–280
- Phase I study of the novel epothilone analog ixabepilone (BMS-247550) in patients with advanced solid tumors and lymphomas. J Clin Oncol. 2007;25:1082–1088
- Phase I clinical trial of BMS-247550, a derivative of epothilone B, using accelerated titration 2B design. Clin Cancer Res. 2005;11:6233–6239
- Phase I clinical and pharmacokinetic study of BMS-247550, a novel derivative of epothilone B, in solid tumors. Clin Cancer Res. 2004;10:1289–1298
- Phase I clinical and pharmacology study of the epothilone analog BMS-247550 given weekly in patients (pts) with advanced solid tumors. Proc Am Soc Clin Oncol. 2001;20:108a;(abstr 427)
- Continuous weekly administration of the epothilone-B derivative, BMS247,550 (NSC710428): A phase I and pharmacokinetic (PK) study. Proc Am Soc Clin Oncol. 2002;21:103a;(abstr 411)
- Phase I study of the novel epothilone BMS-247550 administered weekly in patients (pts) with advanced malignancies. Proc Am Soc Clin Oncol. 2002;21:104a;(abstr 412)
- Phase I trial and pharmacokinetic study of BMS-247550, an epothilone B analog, administered intravenously on a daily schedule for five days. J Clin Oncol. 2003;21:1866–1873
- Phase I and pharmacokinetic study of BMS-247550 in combination with carboplatin in patients with advanced solid malignancies. Proc Am Soc Clin Oncol. 2002;21:78b;(abstr 2125)
- A phase I trial of BMS-247550 (NSC# 710428) and gemcitabine in patients with advanced solid tumors. Invest New Drugs. 2007;25:335–341
- A phase I study of BMS-247550 in combination with capecitabine in patients with metastatic breast cancer previously treated with a taxane and an anthracycline. Breast Cancer Res Treat. 2003;82(suppl 1):S83;(abstr 350)
- . Final efficacy results of a phase I/II trial of ixabepilone in combination with capecitabine in patients with metastatic breast cancer (MBC) previously treated with a taxane and an anthracycline. J Clin Oncol. 2006;24:568s;(abstr 10511)
- Ixabepilone is effective in combination with capecitabine in ER, PR, HER-2 negative (triple negative) patients (pts) resistant to taxanes and anthracyclines: final results from a breast cancer exploratory program. Ann Oncol. 2006;17(suppl 9):ix74;(abstr 159P)
- Phase II trial of ixabepilone, an epothilone B analog, in patients with metastatic breast cancer previously untreated with taxanes. J Clin Oncol. 2007;25:3421–3427
- Phase II clinical trial of ixabepilone (BMS- 247550), an epothilone B analog, in metastatic and locally advanced breast cancer. J Clin Oncol. 2005;23:2726–2734
- Phase II clinical trial of ixabepilone (BMS-247550), an epothilone B analog, in patients with taxane-resistant metastatic breast cancer. J Clin Oncol. 2007;25:3399–3406
- Phase II clinical trial of ixabepilone (BMS-247550), an epothilone B analog, as first-line therapy in patients with metastatic breast cancer previously treated with anthracycline chemotherapy. J Clin Oncol. 2007;25:3415–3420
- Efficacy and safety of ixabepilone (BMS-247550) in a phase II study of patients with advanced breast cancer resistant to an anthracycline, a taxane, and capecitabine. J Clin Oncol. 2007;25:3407–3414
- A phase II study of KOS-862 (epothilone D) in anthracycline and taxane pretreated metastatic breast cancer: Updated results. Breast Cancer Res Treat. 2005;94(suppl 1):S69;(abstr 1087)
- Safety and efficacy of patupilone in patients with advanced breast cancer: A phase IIa trial. Breast Cancer Res Treat. 2006;100(suppl 1):S73–S74(abstr 1107)
- Ixempra™ (ixabepilone) prescribing information. Princeton, NJ: Bristol-Myers Squibb Co; 2007;
- . Ixabepilone and the narrow path to developing new cytotoxic drugs. J Clin Oncol. 2007;25:3389–3391
- Ixabepilone, an epothilone B analog, is effective in ER, PR, HER-2 negative (triple negative) patients (pts): Data from neoadjuvant and metastatic breast cancer (MBC) trials. Ann Oncol. 2006;17(suppl 9):ix97–ix98(abstr 256P)
- Changes in neurologic function tests may predict neurotoxicity caused by ixabepilone. J Clin Oncol. 2006;24:2084–2091
- . Epothilones in breast cancer: Review of clinical experience. Ann Oncol. 2007;18(suppl 5):v16–v21
- Weekly docetaxel as neoadjuvant chemotherapy for stage II and III breast cancer: efficacy and correlation with biological markers in a phase II, multicenter study. Clin Cancer Res. 2003;9:686–692
- Phase II genomics study in patients receiving ixabepilone as neoadjuvant treatment for breast cancer (BC): Preliminary efficacy and safety data. J Clin Oncol. 2005;23:25s;(abstr 586)
- Predicting response to ixabepilone: Genomics study in patients receiving single agent ixabepilone as neoadjuvant treatment for breast cancer (BC). Breast Cancer Res Treat. 2005;94(suppl 1):S31;(abstr 305)
- Ixabepilone plus capecitabine for metastatic breast cancer progressing after anthracycline and taxane treatment. J Clin Oncol. 2007;25:5210–5217
- Epothilone (ixabepilone) plus capecitabine versus capecitabine alone in patients with advanced breast cancer. http://www.clinicaltrials.gov/ct/show/NCT00082433(accessed September 21, 2007)
- Desoxyepothilone B is curative against human tumor xenografts that are refractory to paclitaxel. Proc Natl Acad Sci U S A. 1998;95:15798–15802
- KOS-862 (epothilone D): A comparison of two schedules in patients with advanced malignancies. Proc Am Soc Clin Oncol. 2003;22:135;(abstr 539)
- KOS-862 (epothilone D): Phase I dose escalating and pharmacokinetic (PK) study in patients with advanced malignancies. Proc Am Soc Clin Oncol. 2003;22:223;(abstr 894)
- Phase I study using continuous intravenous (CI) KOS-862 (Epothilone D) in patients with solid tumors. Proc Am Soc Clin Oncol. 2004;22:133s;(abstr 2024)
- Phase I and pharmacokinetic (PK) study of weekly KOS-862 (Epothilone D) combined with gemcitabine (GEM) in patients (pts) with advanced solid tumors. J Clin Oncol. 2005;23:145s;(abstr 2041)
- Phase I trial of KOS-862 (epothilone D) in combination with carboplatin (C) in patients with solid tumors. J Clin Oncol. 2005;23:147s;(abstr 2049)
- A phase I trial of weekly combination KOS-862 (Epothilone D) and trastuzumab in HER-2 overexpressing malignancies. J Clin Oncol. 2006;24:86s;(abstr 2028)
- A study of epothilone D in combination with Herceptin (trastuzumab) in patients with HER-2 positive advanced or metastatic breast cancer. http://www.clinicaltrials.gov/ct/show/NCT00337649(accessed October 11, 2007)
- A phase I clinical and pharmacokinetic study of EPO906 (epothilone B), given every three weeks, in patients with advanced solid tumors. Proc Am Soc Clin Oncol. 2001;20:108a;(abstr 429)
- Phase I dose-finding study of weekly single-agent patupilone in patients with advanced solid tumors. J Clin Oncol. 2005;23:9120–9129
- Two phase IB trials of EPO906 plus carboplatin in patients with advanced malignancies. Proc Am Soc Clin Oncol. 2003;22:143;(abstr 574)
- A phase Ib and pharmacokinetic trial of patupilone combined with carboplatin in patients with advanced cancer. Clin Cancer Res. 2007;13:4178–4184
- Phase Ib/II dose-escalation trial evaluating the safety and tolerability of EPO906 plus capecitabine in patients with advanced cancer. J Clin Oncol. 2004;22:150s;(abstr 2093)
- Phase I dose-escalation trial investigating the safety and tolerability of EPO906 plus gemcitabine in patients with advanced cancer. J Clin Oncol. 2004;22:219s;(abstr 3100)
- Phase I dose-escalation trial investigating the safety and tolerability of EPO906 plus estramustine in patients with advanced cancer. J Clin Oncol. 2004;22:412s;(abstr 4623)
- A phase I study of the novel, third generation epothilone ZK-EPO in patients with advanced solid tumors. J Clin Oncol. 2005;23:147s;(abstr 2051)
- Phase I trial of novel epothilone B analog BMS-310705 IV q 21 days. Proc Am Soc Clin Oncol. 2003;22:129;(abstr 515)
- Phase I clinical study of the novel epothilone B analogue BMS-310705 given on a weekly schedule. Ann Oncol. 2007;18:1548–1553
- Phase I trial of KOS-1584 (a novel epothilone) using two weekly dosing schedules. J Clin Oncol. 2007;25:114s;(abstr 2571)
- Phase I clinical trial of ixabepilone and pegylated liposomal doxorubicin in patients with advanced breast or ovarian cancers: New York Cancer Consortium Trial P7229. J Clin Oncol. 2007;25:114s;(abstr 2570)
- Trastuzumab and ixabepilone in treating women with HER2-positive metastatic breast cancer. http://www.clinicaltrials.gov/ct/show/NCT00079326(accessed September 21, 2007)
- Trastuzumab, ixabepilone, and carboplatin in treating patients with HER2/neu-positive metastatic breast cancer. http://www.clinicaltrials.gov/ct/show/NCT00077376(accessed September 21, 2007)
- A trial of 2 schedules of ixabepilone plus bevacizumab and paclitaxel plus bevacizumab for breast cancer. http://www.clinicaltrials.gov/ct/show/NCT00370552(accessed October 12, 2007)
- This is a neoadjuvant study of AC followed by ixabepilone or paclitaxel in early stage breast cancer that is HER-2 negative and estrogen receptors negative. http://www.clinicaltrials.gov/ct/show/NCT00455533(accessed October 12, 2007)
- Epothilone B in treating patients with CNS metastases from breast cancer. http://www.clinicaltrials.gov/ct/show/NCT00450866(accessed October 12, 2007)
- ZK219477 in patients with breast cancer and brain metastases. http://www.clinicaltrials.gov/ct/show/NCT00496379(accessed October 12, 2007)
- Identification of predictive markers to differentiate ixabepilone from paclitaxel activity in ER-negative breast cancer patients. J Clin Oncol. 2007;25:103s;(abstr 2525)
Dr Vahdat has no relevant financial relationships with commercial interests to disclose.
PII: S0093-7754(08)00042-0
doi: 10.1053/j.seminoncol.2008.02.003
© 2008 Elsevier Inc. All rights reserved.
« Previous
Next »
Seminars in Oncology
Volume 35
, Pages S22-S30
, April 2008
