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Seminars in Oncology
Volume 35, Issue 6
, Pages 569-581
, December 2008
Cognitive Effects of Hormonal Therapy in Older Adults
References
- . Thinking with your gonads: testosterone and cognition. Trends Cogn Sci. 2006;10:77–82
- . Does endocrine therapy for the treatment and prevention of breast cancer affect memory and cognition?. Eur J Cancer. 2007;43:1342–1347
- . Estrogen and cognitive functioning in women. Endocr Rev. 2003;24:133–151
- . Estrogen actions in the central nervous system. Endocr Rev. 1999;20:279–307
- . Sex differences in androgen responsiveness in the rat brain: regional differences in the induction of aromatase activity. Neuroendocrinology. 1996;64:139–145
- . Trophic effects of estradiol on fetal rat hypothalamic neurons. Neuroendocrinology. 1992;56:895–901
- . Glutamate receptor requirement for neuronal death from anoxia-reoxygenation: an in vitro model for assessment of the neuroprotective effects of estrogens. Cell Mol Neurobiol. 1999;19:705–718
- . Neuroprotection against oxidative stress by estrogens: structure-activity relationship. Mol Pharmacol. 1997;51:535–541
- Estrogens may reduce mortality and ischemic damage caused by middle cerebral artery occlusion in the female rat. J Neurosurg. 1997;87:724–730
- . Novel effects of estradiol and estrogen receptor alpha and beta on cognitive function. Brain Res. 2000;883:258–264
- . Aromatase cytochrome P450 and extragonadal estrogen play a role in ischemic neuroprotection. J Neurosci. 2003;23:8701–8705
- . Brain aromatase is neuroprotective. J Neurobiol. 2001;47:318–329
- Androgen receptor mRNA expression in the human hippocampus. Neurosci Lett. 2000;294:25–28
- . Steroid metabolism in the mammalian brain: 5alpha-reduction and aromatization. Brain Res Bull. 1997;44:365–375
- Adult male rat hippocampus synthesizes estradiol from pregnenolone by cytochromes P45017alpha and P450 aromatase localized in neurons. Proc Natl Acad Sci U S A. 2004;101:865–870
- . Dehydroepiandrosterone: biosynthesis and metabolism in the brain. Endocrinology. 1999;140:880–887
- . High-dose anabolic androgenic steroids modulate concentrations of nerve growth factor and expression of its low affinity receptor (p75-NGFr) in male rat brain. J Neurosci Res. 1997;47:198–207
- . Androgen modulates N-methyl-D-aspartate-mediated depolarization in CA1 hippocampal pyramidal cells. Synapse. 1996;23:10–19
- . Testosterone protects cerebellar granule cells from oxidative stress-induced cell death through a receptor mediated mechanism. Brain Res. 2001;892:255–262
- . Low CA1 spine synapse density is further reduced by castration in male non-human primates. Cereb Cortex. 2004;14:503–510
- . Gonadal hormones affect spine synaptic density in the CA1 hippocampal subfield of male rats. J Neurosci. 2003;23:1588–1592
- . Androgens in the etiology of Alzheimer's disease in aging men and possible therapeutic interventions. J Alzheimers Dis. 2007;12:129–142
- Testosterone reduces neuronal secretion of Alzheimer's beta-amyloid peptides. Proc Natl Acad Sci U S A. 2000;97:1202–1205
- . Androgens modulate beta-amyloid levels in male rat brain. J Neurochem. 2003;87:1052–1055
- . Testosterone attenuates beta-amyloid toxicity in cultured hippocampal neurons. Brain Res. 2001;919:160–165
- . Testosterone stimulates rapid secretory amyloid precursor protein release from rat hypothalamic cells via the activation of the mitogen-activated protein kinase pathway. Neurosci Lett. 2000;296:49–52
- . The heat shock-induced hyperphosphorylation of tau is estrogen-independent and prevented by androgens: implications for Alzheimer disease. Proc Natl Acad Sci U S A. 1997;94:6612–6617
- . Ovariectomy and 17beta-estradiol modulate the levels of Alzheimer's amyloid beta peptides in brain. Exp Gerontol. 2000;35:1317–13252000
- . Serum total testosterone is lower in men with Alzheimer's disease. Neuro Endocrinol Lett. 2001;22:163–168
- Free testosterone and risk for Alzheimer disease in older men. Neurology. 2004;62:188–193
- . Low free testosterone is an independent risk factor for Alzheimer's disease. Exp Gerontol. 2004;39:1633–1639
- . One year follow-up study of the association between chemical castration, sex hormones, beta-amyloid, memory and depression in men. Psychoneuroendocrinology. 2004;29:1071–1081
- Association of sex steroid hormones with brain morphology and cognition in healthy elderly men. Neurology. 2005;65:1591–1596
- Endogenous sex hormones, cognitive decline, and future dementia in old men. Ann Neurol. 2006;60:346–355
- . Patterns of cognitive ageing. Psychol Res. 2000;63:308–316
- . The clinical relevance of the relationship between estrogen and cognition in women. J Steroid Biochem Mol Biol. 2007;106:151–156
- . Estrogen effects on the hippocampus and frontal lobes. Int J Fertil Womens Med. 2005;50:67–71
- . Hormone replacement therapy and cognition: systematic review and meta-analysis. JAMA. 2001;285:1489–1499
- . The effect of estrogen replacement therapy on cognitive function in women: a critical review of the literature. J Clin Epidemiol. 1997;50:1249–1264
- . Estrogen and/or androgen replacement therapy and cognitive functioning in surgically menopausal women. Psychoneuroendocrinology. 1988;13:345–357
- . Effects of estrogen on memory function in surgically menopausal women. Psychoneuroendocrinology. 1992;17:485–495
- . Effect of postmenopausal hormone therapy on cognitive function: the Heart and Estrogen/progestin Replacement Study. Am J Med. 2002;113:543–548
- Estrogen plus progestin and the incidence of dementia and mild cognitive impairment in postmenopausal women: the Women's Health Initiative Memory Study: a randomized controlled trial. JAMA. 2003;289:2651–2662
- Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women's Health Initiative randomized controlled trial. JAMA. 2002;288:321–333
- Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: the Women's Health Initiative randomized controlled trial. JAMA. 2004;291:1701–1712
- Conjugated equine estrogens and incidence of probable dementia and mild cognitive impairment in postmenopausal women: Women's Health Initiative Memory Study. JAMA. 2004;291:2947–2958
- . The effects of 3-week estrogen hormone replacement on cognition in elderly healthy females. Psychopharmacology (Berl). 2000;149:129–139
- . The critical period hypothesis: can it explain discrepancies in the oestrogen-cognition literature?. J Neuroendocrinol. 2007;19:77–81
- . Different modes of hippocampal plasticity in response to estrogen in young and aged female rats. Proc Natl Acad Sci U S A. 2001;98:8071–8076
- . Long-term treatment with estrogen and progesterone enhances acquisition of a spatial memory task by ovariectomized aged rats. Neurobiol Aging. 2000;21:107–116
- . Neurotrophin expression in the reproductively senescent forebrain is refractory to estrogen stimulation. Neurobiol Aging. 2001;22:309–319
- . Estrogen replacement therapy and cognitive decline in older community women. J Am Geriatr Soc. 1999;47:518–523
- Hormone therapy, timing of initiation, and cognition in women aged older than 60 years: the REMEMBER pilot study. Menopause. 2006;13:28–36
- . Estrogen exposures and memory at midlife: a population-based study of women. Neurology. 2003;60:1369–1371
- . Hormone therapy and cognitive function: is there a critical period for benefit?. Neuroscience. 2006;138:1027–1030
- . Estrogen- and tamoxifen-associated effects on brain structure and function. Neuroimage. 2004;21:364–371
- . Preliminary assessment of cognitive function in breast cancer patients treated with tamoxifen. Breast Cancer Res Treat. 2000;64:165–176
- Cognitive impairment associated with adjuvant therapy in breast cancer. Psychooncology. 2006;15:422–430
- Anastrozole alone or in combination with tamoxifen versus tamoxifen alone for adjuvant treatment of postmenopausal women with early breast cancer: first results of the ATAC randomised trial. Lancet. 2002;359:2131–2139
- . Does hormone therapy for the treatment of breast cancer have a detrimental effect on memory and cognition? (A pilot study). Psychooncology. 2004;13:61–66
- . The effects of hormone therapy on cognition in breast cancer. J Steroid Biochem Mol Biol. 2003;86:405–412
- Memory impairments with adjuvant anastrozole versus tamoxifen in women with early-stage breast cancer. Menopause. 2007;14:995–998
- . Androgens and the ageing male. Hum Reprod Update. 2002;8:423–433
- . The decline of androgen levels in elderly men and its clinical and therapeutic implications. Endocr Rev. 2005;26:833–876
- . The endocrinology of aging. Science. 1997;278:419–424
- . Longitudinal effects of aging on serum total and free testosterone levels in healthy men (Baltimore Longitudinal Study of Aging). J Clin Endocrinol Metab. 2001;86:724–731
- . Longitudinal assessment of serum free testosterone concentration predicts memory performance and cognitive status in elderly men. J Clin Endocrinol Metab. 2002;87:5001–5007
- . Sex hormones and cognitive function in older men. J Am Geriatr Soc. 2002;50:707–712
- . Age, hormones, and cognitive functioning among middle-aged and elderly men: cross-sectional evidence from the Massachusetts Male Aging Study. J Gerontol A Biol Sci Med Sci. 2005;60:385–390
- Testosterone supplementation improves spatial and verbal memory in healthy older men. Neurology. 2001;57:80–88
- The role of aromatization in testosterone supplementation: effects on cognition in older men. Neurology. 2005;64:290–296
- . Sex steroids modify working memory. J Cogn Neurosci. 2000;12:407–414
- . Testosterone influences spatial cognition in older men. Behav Neurosci. 1994;108:325–332
- . Endogenous sex hormones and cognitive function in older men. J Clin Endocrinol Metab. 1999;84:3681–3685
- . A curvilinear relationship between testosterone and spatial cognition in humans: possible influence of hand preference. Psychoneuroendocrinology. 1996;21:323–337
- . Endogenous sex hormone levels and cognitive function in aging men: is there an optimal level?. Neurology. 2005;64:866–871
- . Testosterone replacement in older hypogonadal men: a 12-month randomized controlled trial. J Clin Endocrinol Metab. 1997;82:1661–1667
- . Effects of transdermal testosterone on cognitive function and health perception in older men with low bioavailable testosterone levels. J Gerontol A Biol Sci Med Sci. 2002;57:M321–M325
- Effect of testosterone supplementation on functional mobility, cognition, and other parameters in older men: a randomized controlled trial. JAMA. 2008;299:39–52
- . Exogenous testosterone alone or with finasteride does not improve measurements of cognition in healthy older men with low serum testosterone. J Androl. 2007;28:875–882
- . Long-term side effects of androgen deprivation therapy in men with non-metastatic prostate cancer: a systematic literature review. Crit Rev Oncol Hematol. 2006;60:201–215
- . Does neoadjuvant hormone therapy for early prostate cancer affect cognition? (Results from a pilot study). BJU Int. 2005;96:48–53
- . Associations between serum testosterone fall and cognitive function in prostate cancer patients. Clin Cancer Res. 2004;10:7575–7582
- Androgen deprivation and cognition in prostate cancer. Br J Cancer. 2003;89:971–976
- . The effects of combined androgen blockade on cognitive function during the first cycle of intermittent androgen suppression in patients with prostate cancer. J Urol. 2003;170:1808–1811
- Altered cognitive function in men treated for prostate cancer with luteinizing hormone-releasing hormone analogues and cyproterone acetate: a randomized controlled trial. BJU Int. 2002;90:427–432
- Quality of life compared during pharmacological treatments and clinical monitoring for non-localized prostate cancer: a randomized controlled trial. BJU Int. 2004;93:975–979
- Impact of androgen deprivation therapy on physical and cognitive function, as well as quality of life of patients with nonmetastatic prostate cancer. J Urol. 2006;176:2443–2447
- . The effect of short-term estradiol therapy on cognitive function in older men receiving hormonal suppression therapy for prostate cancer. J Am Geriatr Soc. 2004;52:269–273
- . Cancer and cancer-therapy related cognitive dysfunction: an international perspective from the Venice cognitive workshop. Ann Oncol. 2008;19:623–629
PII: S0093-7754(08)00185-1
doi: 10.1053/j.seminoncol.2008.08.002
© 2008 Elsevier Inc. All rights reserved.
« Previous
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Seminars in Oncology
Volume 35, Issue 6
, Pages 569-581
, December 2008
