Seminars in Oncology
Volume 36 , Pages S2-S16 , August 2009

Central Nervous System Disease in Hematologic Malignancies: Historical Perspective and Practical Applications

  • Ching-Hon Pui

      Affiliations

    • St. Jude's Children's Research Hospital, Memphis, TN
    • Corresponding Author InformationAddress correspondence to Ching-Hon Pui, MD, St. Jude's Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105
    • ,
  • Eckhard Thiel

      Affiliations

    • Charité University Medicine Berlin, Berlin, Germany

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    Pharmacogenetic determinants of central nervous system (CNS) relapse. VDR, vitamin D receptor; TYM, thymidylate; TYMS, thymidylate synthetase. This research was originally published in Blood. Rocha JC

    Pharmacogenetic determinants of central nervous system (CNS) relapse. VDR, vitamin D receptor; TYM, thymidylate; TYMS, thymidylate synthetase. This research was originally published in Blood. Rocha JC, et al. Pharmacogenetics of outcome in children with acute lymphoblastic leukemia. Blood. 2005;105:4752-8. © the American Society of Hematology.

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    Response Adapted Therapy study for the treatment of central nervous system (CNS) relapse of aggressive lymphoma. AraC, cytarabine; ASCT, autologous stem cell transplant; CR, complete response; ECOG, E

    Response Adapted Therapy study for the treatment of central nervous system (CNS) relapse of aggressive lymphoma. AraC, cytarabine; ASCT, autologous stem cell transplant; CR, complete response; ECOG, Eastern Cooperative Oncology Group; ETO, etoposide; HD-BCNU, high-dose carmustine; IFO, ifosfamide; LC, liposomal cytarabine; NC, no change; MTX, methotrexate; NHL, non-Hodgkin lymphoma; OS, overall survival; PR, partial response; RR, response rate; TTF, time to treatment failure; TT, thiotepa; SC, subcutaneous.

 STATEMENT OF CONFLICT OF INTEREST: The authors received honoraria for lectures from Mundipharma.

PII: S0093-7754(09)00092-X

doi: 10.1053/j.seminoncol.2009.05.002

Seminars in Oncology
Volume 36 , Pages S2-S16 , August 2009

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