Seminars in Oncology
Volume 36 , Pages S17-S24 , August 2009

Understanding the Origins of Gliomas and Developing Novel Therapies: Cerebrospinal Fluid and Subventricular Zone Interplay

  • Michael Glantz

      Affiliations

    • Department of Neurosurgery, Penn State Hershey Medical Center, Hershey, PA
    • Corresponding Author InformationAddress correspondence to Michael Glantz, MD, Penn State Hershey Medical Center, Department of Neurosurgery - EC 110, 30 Hope Drive, PO Box 859, Hershey, PA 17033-0859
    • ,
  • Santosh Kesari

      Affiliations

    • Dana-Farber Cancer Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
    • ,
  • Lawrence Recht

      Affiliations

    • Stanford University School of Medicine, Stanford Cancer Center, Stanford, CA
    • ,
  • Gudrun Fleischhack

      Affiliations

    • Department of Pediatric Hematology/Oncology, University Children's Hospital, Bonn, Germany
    • ,
  • Alexis Van Horn

      Affiliations

    • Tufts Medical Center, Boston, MA

  • Image Result

    Schematic diagram of proposed stem cell hypothesis of glioblastoma multiforme (GBM) tumor formation and repopulation following surgical resection. SVZ, subventricular zone.

    Schematic diagram of proposed stem cell hypothesis of glioblastoma multiforme (GBM) tumor formation and repopulation following surgical resection. SVZ, subventricular zone.

  • Image Result

    Stem cells that putatively form malignant gliomas originate from the transformation of neural stem cells or progenitor cells. Oligodendrocytes and astrocytes may follow the same process.47

    Stem cells that putatively form malignant gliomas originate from the transformation of neural stem cells or progenitor cells. Oligodendrocytes and astrocytes may follow the same process.47

  • Image Result

    Proposed design for a clinical trial evaluating the use of intrathecal (IT) chemotherapy in the initial treatment of newly diagnosed patients with glioblastoma multiforme. RT, radiation therapy; IT, i

    Proposed design for a clinical trial evaluating the use of intrathecal (IT) chemotherapy in the initial treatment of newly diagnosed patients with glioblastoma multiforme. RT, radiation therapy; IT, intrathecal therapy.

 STATEMENT OF CONFLICT OF INTEREST: M.G. has received honoraria and research support from Enzon Pharmaceuticals. The other authors have nothing to disclose.

PII: S0093-7754(09)00093-1

doi: 10.1053/j.seminoncol.2009.05.003

Seminars in Oncology
Volume 36 , Pages S17-S24 , August 2009

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