Seminars in Oncology
Volume 36 , Pages S35-S45 , August 2009

Diagnostic Tools for Neoplastic Meningitis: Detecting Disease, Identifying Patient Risk, and Determining Benefit of Treatment

  • Marc C. Chamberlain

      Affiliations

    • Department of Neurology and Neurological Surgery, Division of Neuro-Oncology, University of Washington, Seattle, WA
    • Corresponding Author InformationAddress correspondence to Marc Chamberlain, MD, University of Washington, Department of Neurology and Neurological Surgery, Chief, Division of Neuro-Oncology, Seattle Cancer Care Alliance, 825 Eastlake Ave E, Mail Stop G4-940, Seattle, WA 98109-1023
    • ,
  • Michael Glantz

      Affiliations

    • Department of Neurosurgery, Penn State Hershey Medical Center, Hershey, PA
    • ,
  • Morris D. Groves

      Affiliations

    • The University of Texas, M. D. Anderson Cancer Center, Houston, TX
    • ,
  • Wyndham H. Wilson

      Affiliations

    • Lymphoma Therapeutics Section, Metabolism Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD

  • Image Result

    Levels of vascular endothelial growth factor in the cerebrospinal fluid over time.

    Levels of vascular endothelial growth factor in the cerebrospinal fluid over time.

  • Image Result

    Proposed clinical trial design for assessing the diagnostic utility of biomarkers in patients at high risk for developing neoplastic meningitis (NM). CSF, cerebrospinal fluid; IT, intrathecal; PF Mets

    Proposed clinical trial design for assessing the diagnostic utility of biomarkers in patients at high risk for developing neoplastic meningitis (NM). CSF, cerebrospinal fluid; IT, intrathecal; PF Mets, posterior fossa metastasis.

 STATEMENT OF CONFLICT OF INTEREST: All four authors have received honorarium from Enzon Pharmaceuticals, as well as serving on the Enzon speaker's bureau. M.G. and M.D.G. have received research support from Enzon Pharmaceuticals.

PII: S0093-7754(09)00095-5

doi: 10.1053/j.seminoncol.2009.05.005

Seminars in Oncology
Volume 36 , Pages S35-S45 , August 2009

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