Seminars in Oncology
Volume 36, Issue 4 , Pages 302-311, August 2009

Gastrointestinal Stromal Tumors II: Medical Oncology and Tumor Response AssessmentDisclosures

  • Robert S. Benjamin

      Affiliations

    • Department of Sarcoma Medical Oncology, University of Texas M.D. Anderson Cancer Center, Houston, TX
    • These authors contributed equally to this work.
    • ,
  • Maria Debiec-Rychter

      Affiliations

    • Department of Human Genetics, Catholic University Leuven, Leuven, Belgium
    • These authors contributed equally to this work.
    • ,
  • Axel Le Cesne

      Affiliations

    • Institut Gustave Roussy, Villejuif, France
    • These authors contributed equally to this work.
    • ,
  • Stefan Sleijfer

      Affiliations

    • Department of Medical Oncology, Erasmus University Medical Center, Daniel den Hoed Cancer Center, Rotterdam, The Netherlands
    • These authors contributed equally to this work.
    • ,
  • George D. Demetri

      Affiliations

    • Dana-Farber Cancer Institute, Ludwig Center, Boston, MA
    • These authors contributed equally to this work.
    • ,
  • Heikki Joensuu

      Affiliations

    • Helsinki University Central Hospital, Department of Oncology, Helsinki, Finland
    • These authors contributed equally to this work.
    • ,
  • Patrick Schöffski

      Affiliations

    • University Hospitals Leuven, Department of General Medical Oncology and Laboratory of Experimental Oncology, Leuven Cancer Institute, Catholic University Leuven, Leuven, Belgium
    • These authors contributed equally to this work.
    • ,
  • Andrés Poveda

      Affiliations

    • Instituto Valenciano de Oncología, Valencia, Spain
    • These authors contributed equally to this work.
    • Corresponding Author InformationAddress correspondence to Andrés Poveda, MD, Instituto Valenciano de Oncología, Prof Baguena 19, Valencia 46009, Spain

The finding of mutations of KIT in gastrointestinal stromal tumors (GISTs) and subsequent development of kinase-directed therapy in metastatic GIST serve as a touchstone for the translation of laboratory research into clinical therapeutics. A variety of novel developments have followed the discovery of clinical activity of kinase-directed therapy against GIST. Radiological assessment of GIST challenges the standard of care for assessing tumor responses, ie, Response Evaluation Criteria in Solid Tumors (RECIST). Furthermore, the determination of the relationship of specific KIT mutations and sensitivity and resistance to kinase-directed agents and the assessment of inhibitor levels and the quality of response to those agents have implications beyond the treatment of sarcomas. These discoveries and the next chapters in this developing story are discussed in this review.

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Disclosures R.S. Benjamin: Novartis (consulting, speaker's bureau)M. Debiec-Rychter: Novartis (research support)A. Le Cesne: Novartis (honoraria)S. Sleijfer: Pfizer, Novartis (research support)G.D. Demetri: Novartis, Pfizer, Ariad, Johnson & Johnson, Genentech, Plexxikon, Bristol Meyers Squibb Research, Infinity Pharmaceuticals, Ziopharm, Alnylam, Idera, Bayer, Serono, Amgen (research support, consulting)H. Joensuu: Novartis, Bayer-Schering Pharma (honoraria), testimony (Pfizer)P. Schöffski: Novartis (research funding and honoraria); Pfizer (research funding and honoraria)A. Poveda: none

PII: S0093-7754(09)00103-1

doi:10.1053/j.seminoncol.2009.06.003

Seminars in Oncology
Volume 36, Issue 4 , Pages 302-311, August 2009

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