Impact of malignant disease on young adults IICancer of the Oral Cavity and Pharynx in Young Females: Increasing Incidence, Role of Human Papilloma Virus, and Lack of Survival Improvement
Section snippets
Methods
Incidence data were obtained from the Surveillance, Epidemiology and End Results (SEER) program of the National Cancer Institute18 via SEER*Stat.version 6.4.4 (April 26, 2008) on March 15, 2009.19 To evaluate incidence trends from 1975–2005, the original nine SEER registries (SEER9) were used, consisting of Connecticut, Iowa, New Mexico, Utah, Hawaii, the metropolitan areas of Detroit, San Francisco-Oakland, Atlanta, and 13 counties of the Seattle–Puget Sound region. In 1992, four additional
Results
In the nine original registries of the US SEER program (SEER9), females less than 40 years of age sustained an increase in OC/P cancer since the 1990s, that by 2005 was approximately 20% higher among 10- to 39-year-old females than the corresponding rates in the 1980s (Figure 1). Among 10- to 24-year-old females, the corresponding increase was 50%, and among 25- to 39-year-old females, 15% higher (data not shown). The trend is the reverse of that in older females, in whom 40- to 59-year-olds
Discussion
The American Cancer Society estimates that 35,720 Americans (25,240 males and 10,480 females) will be diagnosed to have OC/P cancer in 2009.20 Of these, approximately 6% of the cases are diagnosed before age 40.19 The American Cancer Society report continues to describe a decreasing incidence of OC/P cancers since the 1980s in both men and women.20
This study reports a reversal of this trend in females less than 40 years of age that appears to have occurred in the early 1990s and resulted in an
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